Abl Diagnostics Sa · EURONEXT:ABLD
Abl Diagnostics Sa — Advanced Biological Laboratories (ABL) — Investor Presentation (September 2021)
34 slides from Abl Diagnostics Sa's investor presentation, September 2021
Slide 1: DeepChek-HIV Assays & Software Presentation
Improving Disease Management DEEPCHEK®-HIV ASSAYS & SOFTWARE End-to end Solutions for HIV Genotyping for Drug Resistance Assessment (SANGER & NGS) PRESENTATION Confidential & Proprietary ABL Do Not Distribute – Strictly Private and Confidential
Slide 2: Presentation of ABL
Presentation of ABL Confidential & Proprietary ABL http://www.ablsa.com September 2021 2 Do Not Distribute – Strictly Private and Confidential
Slide 3: About us
About us Advanced Biological Laboratories (ABL), S.A., is a diagnostic and medical software company founded in 2000 as a spin-off from LIH (Luxembourg) --- ABL’s mission is to develop, manufacture and commercialize proprietary end-to-end diagnostic solutions for infectious diseases and oncology, in
Slide 4: An international, fully-integrated Diagnostics company
An international, fully-integrated Diagnostics company R&D Regulatory (software + labs) Administration / Manufacturing / Financial Storage A fully-integrated company developing & commercializing innovative diagnostics products for Training / infectious diseases Logistics Support Marketing / Sales Co
Slide 5: Presentation of ABL Genotyping solutions
Presentation of ABL Genotyping solutions Confidential & Proprietary ABL http://www.ablsa.com September 2021 5 Do Not Distribute – Strictly Private and Confidential
Slide 6: Workflow Overview
Workflow Overview GENOTYPING SANGER sequencing RNA PCR Data analysis extraction NGS sequencing Lab & data analysis automation SANGER NGS Turnaround time ~17h ~3-4 days Hands-on-time ~40min ~1-3 h TAT ~30min TAT ~4h30 TAT ~12h TAT ~15min SANGER HOT ~15min HOT ~10min HOT ~5min HOT ~10min TAT ~30min TA
Slide 7: Pipetting Robot
Pipetting Robot LIBRARY PREPARATION Fragmentation Fragmentation End-repair & A-tailing End-repair & A- Adaptor ligation set-up & plate set-up reaction plate set-up tailing reaction reaction on-deck LIBRARY CLEAN-UP AMPLIFICATION SPRI clean-up PCR Centrifuge Post PCR clean-up & PCR mix distribution N
Slide 8: Software workflow
Software workflow Cloud Secured Healthcare environment (HDS) Nadis, HIV Ref Lab in Rouen… Local Virtual Private Server Local Hardware Confidential & Proprietary ABL http://www.ablsa.com September 2021 8 Do Not Distribute – Strictly Private and Confidential
Slide 9: Regulated applications
Regulated applications GENOTYPING RT/PR HIV INT Virology Whole SARS-CoV-2 Genome NS5B/5UTR HCV ONGOING GT Tuberculosis 13-Plex ONGOING Bacteriology Taxonomy 16s RNA ONGOING Confidential & Proprietary ABL http://www.ablsa.com September 2021 9 Do Not Distribute – Strictly Private and Confidential
Slide 10: Research use applications
Research use applications GENOTYPING HIV V3 Loop SARS-CoV-2 8-Plex Core GT HCV DR (NS5A, NS3,NS5B) Virology HBV RT / Core CMV UL97/54 DR HSV TK/POL DR HPV L1 GT Bacteriology Tuberculosis inhA/rpoB Confidential & Proprietary ABL http://www.ablsa.com September 2021 10 Do Not Distribute – Strictly Priv
Slide 11: Examples of reports
Examples of reports GENOTYPING HIV HBV HCV TB HPV CMV HSV 16s RNA Confidential & Proprietary ABL http://www.ablsa.com September 2021 11 Do Not Distribute – Strictly Private and Confidential
Slide 12: HIV Genotyping solutions
HIV Genotyping solutions Confidential & Proprietary ABL http://www.ablsa.com September 2021 12 Do Not Distribute – Strictly Private and Confidential
Slide 13: HIV Workflow Overview
DEEPCHEK®-HIV ASSAYS & SOFTWARE Workflow Overview HIV Sample Preparation PCR Manual Automatic RT/PR INT V3 Loop RNA extraction DeepChek® HIV assays SANGER sequencing NGS sequencing Library preparation Indexes Purification Sequencing reagents (24/48/96/384) DeepChek® SANGER Sequencing Reaction DeepCh
Slide 14: DeepChek HIV Assays Highlights
DEEPCHEK®- HIV ASSAYS Highlights HIV ▪ LoD: 1000 copies/mL (down to ~50-100 copied/mL) ▪ High analytical reproducibility and repeatability were evidenced by Percent Agreement being 100% ▪ Highly specific –pure & CRF strains ▪ From sample to drug resistance in ~17 hours for SANGER & 3-4 daya for NGS
Slide 15: ABL Plan for IVDR
DEEPCHEK®-HIV ASSAYS & SOFTWARE ABL Plan for IVDR HIV • Production of the IVD kits is already ISO 9001 certified • Full design, development, production and support of IVD medical devices process is compliant with the ISO 13485:2016 • Since 2019, the Quality Management System (QMS) is developed to be
Slide 16: Reporting
DEEPCHEK®-HIV ASSAYS & SOFTWARE Reporting HIV SANGER NGS Confidential & Proprietary ABL http://www.ablsa.com September 2021 16 Do Not Distribute – Strictly Private and Confidential
Slide 17: HIV software: web-based system
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 18: System availability
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 19: Secured data access
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 20: Embedded chromatogram editor
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 21: Single or cumulative genotyping
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 22: Comet phylogenetic analysis subtyping
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 23: Virtual phenotyping
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 24: Drug resistance assessment
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 25: GSS & regimen ranking
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 26: Tropism determination
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 27: Report validation
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 28: Contamination check
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 29: Quality control
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 30: Data export
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 31: Batch analysis, large scale
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 32: Data mining
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 33: Automation and LIMS / HIS integration
VIROSCORE® & DEEPCHEK®- HIV SOFTWARE Highlights HIV Technology Security Main features Additional features Services •Web-based (browser •Data access restriction •SANGER data •Report customization •Constant updates only) (pools, read-only management (AB1, •Contamination check •Annual upgrades •Softwar
Slide 34: Contact
CONTACT ▪ Advanced Biological Laboratories S.A. ▪ 52- 54 Av du X Septembre, Luxembourg ▪ contact@ablsa.com ▪ https://www.ablsa.com ▪ TEL : (+352) 26 38 96 761 ▪ FAX : (+352) 26 38 96 76 31 34 September 2021 http://www.ablsa.com
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