Natera, Inc. · NASDAQ:NTRA

Natera — Fact Sheet (June 2014)

6 slides from Natera's fact sheet, June 2014

  1. Slide 1: Horizon Carrier Screen: What Matters

    ay horizon carrier screen What Matters for Cystic Fibrosis for Fragile X fo} for SMA for Ashkenazi Jewish Panel Conceive. Deliver.

  2. Slide 2: Carrier Risk and Detection Rates by Ethnicity

    CARRIER RISK HORIZON (127) ACMG (23) PANEL ETHNICITY BEFORE DETECTION DETECTION TESTING 1 RATE 5 RATE 6 Caucasian 1 in 25 >91% >88% Ashkenazi Jewish 1 in 24 >97% >94% African American 1 in 61 >80% >65% Hispanic 1 in 46 >79% >72% Asian 1 in 94 >49% >49%

  3. Slide 3: Horizon Screened Conditions and Carrier Frequencies

    CARRIER CUMULATIVE SCREENS CONDITIONS FREQUENCY 1 CARRIER RISK 1 Bloom syndrome 1 in 107 Canavan disease 1 in 41 Cystic Fibrosis 1 in 24 Familial Dysautonomia 1 in 31 Fanconi Anemia, Group C 1 in 89 Fragile X syndrome 1 in 259 Standard Gaucher disease 1 in 18 1 in 4 Glycogen Storage disease, type 1a

  4. Slide 4: Enhanced Carrier Testing for Spinal Muscular Atrophy

    Enhanced Carrier Testing for Spinal Muscular Atrophy Residual Risk Estimates ENHANCED RESIDUAL RESIDUAL CARRIER CURRENT RESIDUAL RISK DETECTION RISK RISK ETHNICITY FREQUENCY DETECTION AFTER NEGATIVE RATE WITH g.27134T>G* g.27134T>G* RATE RESULT* g.27134T>G NEGATIVE POSITIVE 4 14 4 4 4 Ashkenazi Jewi

  5. Slide 5: Fragile X FMR1: Impact of AGG Interruptions on CGG Repeat Expansion

    FRAGILE Fragile X FM X FMR1 R 1 GGene: ENE: I M PA C TImpact O F AofG AGG G I NInterruptions T E R R U P T on I O CGG NS ORepeat N C GExpansion G R E P E AT E X PA N S I O N * 100% Probability of Expansion to Full Mutation NUMBER OF 90% CATEGORY REPEATS 0 AGG 80% 5 Normal <45 1 AGG 70% 2 AGG Interme

  6. Slide 6: Offer a Comprehensive DNA-Based Prenatal Screening Solution

    HORZ-MD-FACT-REVS(6/11/14) Offer a Comprehensive DNA-Based Prenatal Screening Solution Although preconception screening is ideal, many women first recognize the value of carrier screening at their first prenatal visit. Having a lab partner with a comprehensive offering is bene- ficial to you and you

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