Slide 1: Investor Presentation May 2015
M1 INTERVENTIONS, Ticker: MRIC Investor Presentation May 2015 Transforming minimally invasive neurosurgery by enabling real-time visualization with MRI
Slide 2: Forward-Looking Statements
Forward-Looking Statements estimates," "will," "woul nticipates," "believes," "could," ". "expects," "intends," "may," “plans,” "potential," "predicts," “projects, "should," "will," negative 0 of these words or other words of similar meaning. to different dey MRI Interventions’ mee e fl productivity
Slide 3: MRI Interventions Opportunity
MRI Interventions Opportunity = Market is large and growing Large Market I = Laser Ablation for Navigation System for Multip' . Tumors = Brain Tumol 5 ‘ Large Opportunity ctin; . — Medtronic, St. market Multiple Players — MRI Scanner uel Uniquely Positioned — Strong, proprietary position
Slide 4: MRI Interventions: Real Time MRI Guided Surgery
MRI Interventions: Real Time MRI Guided Surgery Company Highlights
Slide 5: Significant Med Device Experience
nificant Med Device Experience Executive Title Prior Experience Frank Grillo President, CEO INT UT TYE KYBHON. slitithic Peter Piferi coo 1)‘ Weanwore Cordis. Wendelin Maners VP Marketing Boston. CSA MEDICAL Robert Korn VP sales Pmedtronic Codman Hal Hurwitz cro je oe Board of Directors Kimble Jenki
Slide 6: Minimally Invasive, Visualized Procedures
Minimally Invasive, Visualized Procedures Cardiovascular Su Revelunoiaed iby inworosco in the late 1970's Today: 1.5 million procedures/yr Orthopedic Surgery Revolutionized by arthroscopy in the 1980's Today: 1.2 million procedures/yr ‘Abdominal Surgery Revolutionized by laparoscopy in the late 1980
Slide 7: Minimally Invasive Neurosurgery with ClearPoint
Minimally Invasive Neurosurgery with ClearPoint® blind No visualization
Slide 8: Surgical Platform
ClearPoint Surgical Platform Emory University Hospital Diagnostic Scanner upMc Diagnostic Scanner ICSF Medical Center * 510(k) clearance and CE Mark approval u Diagnostic Scanner * Over 700 procedures performed to date
Slide 9: Procedure Overview
ClearPoint Procedure Overview
Slide 10: Procedure Overview
ClearPoint Procedure Overview SmartFrame® Trajectory Guide id] a
Slide 11: Procedure Overview
ClearPoint Procedure Overview (1) or ety The Smantow” an coved 51 deans meen of craig a chemotherapy uth ees of enava of Som he venice ung isto ra ie avalon a rascal te er cea i
Slide 12: Hospital Economics
ClearPoint Hospital E Increase Patients E: tal blished, with equivalent reimbursement 1 hour of MR Scanner time used for Potential Revenue per MRI Hour + Lhour of MR scanner time used for a ClearPoint procedure could generate 752) Diagnostic ClearPoint fa sae eral ean peek ine eee ld semen al ve eve
Slide 13: Multi-Therapy MRI-Guided Navigational System
Multi-Therapy MRI-Guided Navigational System SIEMENS | PHILIPS | |GeHealthcare | IMRISO BrainSUITE
Slide 14: Strong Base of Clinical Support
Strong Base of Clinical Support Haap 4 Dr. Philip Starr Dr. Paul Larson Dr. Robert Gross Dr. Robert Wharen,Jr. Dr. Krys Bankiewicz Dr. Russ Lonser ASSEN Past President UCSF & VA Emory University Mayo Clit Bankiewicz Lab, UCSF (OSU-NIH Jacksonville
Slide 15: Patient Impact
Patient Impact Martin’s Story ClearPoint-Enabled Electrode Placement
Slide 16: Patient Benefit - Minimally Invasive Procedure
Patient Benefit - Minimally Invasive Procedure MRI
Slide 17: The ClearPoint Difference
The ClearPoint Difference Without ClearPoint (Stereotactic) With ClearPoint fi izati i i Direct, high room an MRI Suite Long procedures — Can be up to 8 hours Shorter procedures — Can be 3 hours or less brief trainin, ClearPoint is a win-win-win (A) trotectrode recording ad macrostin ae processes th
Slide 18: MRIC's Unique Opportunity in Drug Delivery
MRIC‘s Unique O ity in Drug Pelivery without Busi Model Drug company/sponsor pays for trial drug is approved BD _| AAV2+nAADC for Parkinson's disease - Phase 1 study at UCSF nua ce Brain Tumor ~ Phase 1 study at NIH saNorl | _>_ Sanofi~ Genzyme; Michael J. Fox Foundation red by NIH vuniQure, 8. ~_ S
Slide 19: Strong Intellectual Property
Strong Intell | Property MRI Interventions Patent Portfolio 50+ U.S. Patents } 45+ OUS Patents } 40+ US. Patent Applications 50+ OUS Patent Applications technology disp sos of Aug.11,2014 MRI
Slide 20: Growing the ClearPoint Footprint
Growing the ClearPoint Footprint 41 ClearPoint Sites
Slide 21: Revenue Model
ClearPoint Revenue Model BUSINESS MODEL — RAZOR / RAZORBLADE . $150,000 ASP
Slide 22: U.S. Market Opportunity — Current
ClearPoint U.S. Market Opportunity — Current P Fetis are Demographics Prevalence 1,500,000 2,200,000 N/A Inciden« 60,000 150,000 180,000 (New agnosis a) Surgeries (2012) 3,125 7,660 Resections: 80,000 Stereotactic Biopsy: 10,000 Current Potential Cl ClearPoint-enabled Electrode Placement Laser Ablat
Slide 23: U.S. Market Opportunity — Future
ClearPoint U.S. Market Opportunity — Future — Regulatory Status | Total Patient # of Potentially: ‘Total Potential Ly Of Therapy Population ‘Addressable Cases | Addressable Cases e Des HDE 250,000 25,000 | ] DBs HDE 3,300,000 100,000 | 182,500 | Brain Mets Laser Ablation ‘Approved 115,000 57,500 | |
Slide 24: Sites, end of Q1, 2015
ClearPoint Sites, end of Q1, 2015 CONFIDENTIAL - DO NOT COPY OR DISTRIBUTE
Slide 25: Consumable Revenues
ClearPoint C ble Revenues | Consumables $1,200,000 $1,000,000 $800,000 $600,000 $400,000 $200,000 $s qi a a a4 a a2 3 2013 a4 2014 2015 _ MRI
Slide 26: Total Product Revenues
Total Product Revenues Consumables mCapital/Service m™ Other $1,200,000 $1,000,000 $800,000 $600,000 $400,000 $200,000 1 $ at a2 a3 at a2 03 «64a. 2013 2014 2015 _ MRI
Slide 27: Commercial Plan
Commercial P Increase Utilization Target high volume Jeep Brain Stimulation (DBS), jlepsy and Tumor neurosurgeons; ee re oftheir procedure: Expand use of ClearPoint beyond within existing res through tanda ne: zo ith a Be training Enhance Communication Increase peer-to-peer events, presence at trade
Slide 28: At the Center of an Emerging Industry Trend
At the Center of an Emerging Industry Trend
Slide 29: MRI Interventions, Inc.
~~ VI INTERVENTIONS, Ticker: MRIC MRI Interventions, Inc. Irvine, CA 949-900-6833 ir@mriinterventions.com
Slide 30: Neuro Intervention System
ClearPoint Neuro Intervention System 7 (a
Slide 31: Neuro Intervention System
ClearPoint Neuro Intervention System id] a