Endonovo Therapeutics, Inc. · OTC:ENDV
Endonovo Therapeutics — Investor Presentation (March 2020)
26 slides from Endonovo Therapeutics's investor presentation, Mar 2, 2020
Slide 1: SofPulse Overview
SofPulse® Overview Endonovo = Therapeutics For Informational Purposes Only
Slide 2: Disclosure & Forward Looking
Disclosure & Forward Looking THE INFORMATION CONTAINED HEREIN IS CONFIDENTIAL AND IS INTENDED ONLY FOR THE USE OF THE PERSON TO WHOM IT IS TRANSMITTED BY ENDONOVO THERAPEUTICS. NEITHER THIS PRESENTATION NOR ANY PART OF IT MAY BE COPIED, DISCLOSED OR TRANSFERRED WITHOUT EXPRESS WRITTEN CONSENT OF END
Slide 3: Endonovo Overview
Endonovo Overview * Endonovo Therapeutics (to renew from within) is an innovative biotechnology company developing a bioelectronic approach to regenerative medicine ¢ Purchased IP from Ivivi in 2017 * Publicly traded: OTCQB: ENDV * Portfolio addresses wound healing, pain, post-surgical pain and edem
Slide 4: The Opioid Crisis
The Opioid Crisis Between 1999 and 2017, deaths from prescription opioid overdoses increased by 5-fold,! and in 2017, accounted for over 35% of all opioid-related deaths.2 80% PEOPLE USING HEROIN FIRST MISUSED PRESCRIPTION OPIOIDS® 51M 22M 2M ANNUAL OPERATIVE ANNUAL SURGICAL PEOPLE WITH AN OPIOID PR
Slide 5: Reducing Use of Narcotics and NSAIDS
Reducing Use of Narcotics and NSAIDS * Side effects of narcotics are: — Reduced mental status makes participating in care plan difficult for the patient — Constipation must be treated with other medications and treatments like enemas — Reduced mobility leading to possible respiratory, renal, cardiov
Slide 6: The SofPulse Solution
The SofPulse® Solution deo at: vww.getsofpulse.com
Slide 7: Effective Postop Relief Has Come Full Circle
Effective Postop Relief Has Come Full Circle SofPulse® is an FDA-cleared non-opioid postoperative option that is clinically proven to relieve pain and reduce edema.1 \e Its proprietary technology delivers targeted Pulsed Electromagnetic Field Therapy (tPEMF) to injured tissues, activating the body’s
Slide 8: Effective Postop Relief Has Come Full Circle
Effective Postop Relief Has Come Full Circle EFFECTIVE? SofPulse® has demonstrated outstanding clinical results in postoperative pain, edema, and opioid use: 2.2X 300% 275% POSTOP USE MEAN PAIN INFLAMMATION OF NARCOTICS SCORES AND SWELLING at 48 hours at 5 hours* at 18 hours SAFE? + Electric field e
Slide 9: Applicator
SofPulse® Applicator { * Application area = 7.5 inch \ diarmetecol ding ‘\ XY R \ Treatment depth = 5 inches \ ON/OFF button ) je Therapy applicator (7.5" in diameter) Lights that flash during therapy Embedded signal generator, processor and batteries * The electric fields transmitted into tissues a
Slide 10: Mechanism of Action
Mechanism of Action Millions of micro-pulses. One solution. Clinical studies have shown that SofPulse® reduces Interleukin 1-8 by 275%, speeding up and enhancing the recovery process.t The proprietary tPEMF signal activates the nitric oxide cascade, a key anti-inflammatory and cellular pathway. The
Slide 11: Clinical Evidence
SofPulse® Clinical Evidence Effects of Pulsed Electromagnetic Fields on Postoperative Pain: A Double-Blind Randomized Pilot Study in Breast Augmentation Patients. Authors: Per Heden, Pilla AA. Citation: Aesth Plast Surg. 2008;32:660-666. Effects of pulsed electromagnetic fields on interleukin-1 beta
Slide 12: Clinical Evidence
SofPulse® Clinical Evidence SofPulse® in Breast Augmentation Procedures? Background A double-blind, randomized, placebo-controlled pilot study was undertaken to evaluate the effect of tPEMF transmitted by SofPulse® on postoperative pain following breast augmentation procedures. Methods * 42 females
Slide 13: Clinical Evidence
SofPulse® Clinical Evidence SofPulse® in Breast Reduction Procedures Background A double-blind, randomized, placebo-controlled study was conducted to examine the effect of tPEMF transmitted by SofPulse® on postsurgical pain and cytokine and growth factor concentrations in wound exudates following br
Slide 14: Clinical Evidence
SofPulse® Clinical Evidence SofPulse® in TRAM Flap Breast Reconstruction Procedures? Background A double-blind, randomized, placebo-controlled study examined the effect of pulsed electromagnetic field therapy on postoperative pain, inflammation, and narcotic pain medication requirements in patients
Slide 15: Clinical Evidence
SofPulse® Clinical Evidence SofPulse® in Breast Reduction Procedures! Background This prospective study was conducted to determine the effect of tPEMF dosing frequency on postoperative pain reduction following breast reduction procedures. The study added two active (non- randomized) cohorts to a pre
Slide 16: Competitive Overview
SofPulse® Competitive Overview PAIN RELIEF + REDUCED EDEMA - OPIOIDS = SOFPULSE® SofPulse® is a nonpharmacologic pain solution clinically Exparel® proven to reduce postoperative pain and edema.! On-Q* Additionally, SofPulse® has been shown to reduce the use Ofirmev? SofPulse® of narcotic analgesics
Slide 17: Feedback
SofPulse® Feedback "Patients are excited to have other options post-surgery to avoid the potential harmful and additive properties of narcotics” Dr. Roc McCarthy Urological Surgeon Chair of Robotics Committee NHRMC
Slide 18: Feedback
SofPulse® Feedback “Flectroceutical® therapeutic devices are a fascinating frontier of pain management, and Endonovo’s SofPulse® approaches the industry in a safe manner while fighting the opioid epidemic head on. There is a major need for therapeutics that improve the post-operative pain management
Slide 19: Feedback
SofPulse® Feedback ‘Tam excited to collaborate with the team at Endonovo Therapeutics. Endonovo's goal of targeting pain management has produced an encouraging level of acceptance of SofPulse® among the medical community in such a short period of time.” Dr. Geoffrey Abrams Assistant Professor of Ort
Slide 20: Feedback
SofPulse® Feedback ‘Tt is a great opportunity to participate in developing Endonovo's promising fight to support pain management and healing ina natural and holistic way. I look forward to helping guide Endonovo's breakthrough treatments and fight against the opioid crisis as a member of the scienti
Slide 21: Feedback
SofPulse® Feedback ‘This device that has the most solid science behind it of all of the devices I have seen come through our lab. The clinical success I have had with patients is unsurpassed.” Dr. Nev Zubcevik Chief Medical Officer, Endonovo Therapeutics Physical Medicine and Rehabilitation Speciali
Slide 22: Simple Application and Treatment
Simple Application and Treatment 71 Ww SofPulse® is designed to be worn continuously during the 8-day treatment period SofPulse® may be removed for short periods of time for dressing changes or washing after which, it should be re-secured to the body Tape or otherwise secure the SofPulse® applicator
Slide 23: Simple Application and Treatment
Simple Application and Treatment ities, = SHOULDER KNEE HIP With broad usage in a variety of surgical specialties, SofPulse® should be fixed into position over the surgical wound dressing.
Slide 24: Use in Surgical Specialties
Use in Surgical Specialties SofPulse® may be used in a variety of clinical specialties, including: * Bariatric * Ortho + Burns * Spine * — Cardiac/Thoracic + Urology + Foot & Ankle * Vascular * General Surgery * GYN + Plastic Surgery + Podiatry
Slide 25: Current Studies
Current Studies SofPulse® is being currently studied in the following clinical trials: Recently in the News Effect of Pulsed Electromagnetic Field Therapy on Pain After Cesarean Delivery https://clinicaltrials. gov/ct2/show/NCT02365753?term=sofpulse&draw= 2Brank=3 Pulsed Electromagnetic Field (PEMF)
Slide 26: Thank You!
\ \ \ ON/OFF button ] THANK YOU! ia Lights that flash during therapy Embedded signal generator, processor and batteries
Endonovo Therapeutics — Investor Presentation (March 2020) on 6ix