Satellos Bioscience Inc · TSX:MSCL
Satellos Bioscience — 30th Annual PPMD Conference 2024
12 slides from Satellos Bioscience's conference presentation, Jun 29, 2024
Slide 1: Muscle regeneration: the next horizon
30th Annual PPMD Conference Orlando, Florida | June 29, 2024 Muscle regeneration: the next horizon TM
Slide 2: Legal Disclaimers
Legal Disclaimers Certain statements in this presentation are “forward-looking statements” under applicable securities laws. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, assumptions or future events or performa
Slide 3: Satellos is based on a landmark discovery
Satellos is based on a landmark discovery What this means for patients Duchenne is also a stem cell disease Potential for a new treatment intended to bring muscle back New muscle cells are not being created as needed for ongoing fiber repair and regeneration, resulting in muscle being lost. What S
Slide 4: SAT-3247: A pill to regenerate muscle
SAT-3247: A pill to regenerate muscle 3247 Dystrophin Independent Dystrophin Dependent Oral medicine to restore muscle regeneration Genetic medicines to stabilize muscle fibers 3247 3247 3247 3247 3247 3247 3247 3247 3247 3247 3247 32 3247 3247 3247 3247 actual size 3247 3247 3247 3247 3247 Satellos
Slide 5: Satellos discovery confirmed in Duchenne patients
Satellos discovery confirmed in Duchenne patients Individual patient biopsies at different ages* Clinical reports show that Duchenne patients have muscle stem cells As we discovered in Mdx mice, there are not enough progenitor muscle cells Thus, muscle fibers cannot repair themselves in respon
Slide 6: Muscle stem cells need a 'signal' from dystrophin to repair and regenerate muscle fibers
Muscle stem cells need a ‘signal’ from dystrophin to repair and regenerate muscle fibers Dystrophin Signal Present: Dystrophin Signal Missing: Regeneration Occurs Regeneration Impaired Many progenitor Few stem cells to Too few progenitor cells to Surplus of cells to build muscle maintain pool build
Slide 7: Muscle stem cells need a 'signal' from dystrophin to repair and regenerate muscle fibers
Muscle stem cells need a ‘signal’ from dystrophin to repair and regenerate muscle fibers Dystrophin Signal Present: Dystrophin Signal Missing: Regeneration Occurs Regeneration Impaired Many progenitor Few stem cells to Too few progenitor cells to Surplus of cells to build muscle maintain pool build
Slide 8: SAT-3247 resets progenitor cell production and increases muscle force, a result of regeneration
SAT-3247 resets progenitor cell production and increases muscle force, a result of regeneration In vitro In vivo (Mdx) MyoReGenXTM(1) 28-day Treatment with SAT-3247 mdx mice n = 10/group Progenitors as measured by 3247 increases progenitors 3247 increases muscle force 1. MyoReGenX is Satellos’ propr
Slide 9: Preliminary SAT-3247 results show improvements in canine model of DMD
Preliminary SAT-3247 results show improvements in canine model of DMD (interim data from pilot study*) Regenerative status Muscle force 4-months of dosing with SAT-3247 2-months of dosing with SAT-3247 IgG+ve (damage) Hindlimb Forelimb Start of dosing Start of dosing Dosing Dosing Newtons Newtons Ag
Slide 10: SAT-3247 is about to enter clinical trials
SAT-3247 is about to enter clinical trials SAT-3247 Ph 1a Ph1a IND filing --------------- 1st subject Safety/ PK Ph 2 POC dosed Readout DMD Q3 - 2024 Q4 – 2024 Q1 - 2025 Q2 - 2025 Ph 1a | Safety & PK Ph 1a | Safety & PK & Biomarkers ----------------- ----------------- Healthy Volunteers Duchenne Pat
Slide 11: Satellos has built an outstanding, experienced team to develop SAT-3247
Satellos has built an outstanding, experienced team to develop SAT-3247 Frank Gleeson, MBA Liz Williams, CPA, CA Philip Lambert, PhD Michael Cross, PhD, MBA Courtney Wells Michael Rudnicki, OC, PhD, FRS Co-Founder & Chief Financial Officer Chief Scientific Officer Chief Business Officer Co-Founder &
Slide 12: REIMAGINE. REGENERATE. REALIZE the next horizon
REIMAGINE how muscle degeneration is treated. REGENERATE with small molecule medicines. REALIZE the next horizon to improve lives. Thank you to:
Satellos Bioscience — 30th Annual PPMD Conference 2024 on 6ix