Spire Healthcare Group PLC · LSE:SPI
Spire Healthcare — Technical Presentation
10 slides from Spire Healthcare's technical presentation
Slide 1: Psoriasis Overview
PSORIASIS OVERVIEW SIMON DAVISON DERMATOLOGY CONSULTANT BHR NHS TRUST SPIRE RODING HOSPITAL HOLLY HOUSE HOSPITAL
Slide 2: Psoriasis Co-morbidities
PSORIASIS C0-MORBIDITES • Is psoriasis associated with obesity?
Slide 3: Psoriasis Co-morbidities
PSORIASIS CO-MORBIDITIES • Multiple studies worldwide show clear association with obesity, diabetes, dyslipidaemia, metabolic syndrome, fatty liver disease • Large population studies have shown increased risk of metabolic syndrome: 2-fold increased risk (USA), 2.6-fold increased risk (Europe), 4.5-f
Slide 4: Psoriasis and Obesity
PSORIASIS AND OBESITY • Cause or effect?
Slide 5: Psoriasis Co-morbidities
PSORIASIS CO-MORBIDITIES • Obesity in adolesence predates psoriasis • Weight reduction improves psoriasis (post gastric bypass) • ? Shared genetic tendency • ? Linked pathophysiology - visceral adipose an active endocrine organ secreting pro-inflammatory cytokines (adipokines) such as TNF-a and inte
Slide 6: Psoriasis and Metabolic Syndrome
PSORIASIS AND METABOLIC SYNDROME • Some evidence that systemic treatment of psoriasis (methotrexate and anti-TNF-a therapy) lowers cardiovascular risk. • Benefits of omega 3 oils (oral supplements and intravenous therapy) for psoriasis • Can make psoriasis treatment difficult: fatty liver with metho
Slide 7: Chronic Plaque Psoriasis
CHRONIC PLAQUE PSORIASIS • Several available treatments • What should we try first? • What regime should we use? • Poor patient compliance common
Slide 8: Flexural (Inverse) Psoriasis
FLEXURAL (INVERSE) PSORIASIS • Problems with irritancy and atrophy limits available products
Slide 9: Scalp Psoriasis
SCALP PSORIASIS • >50% of patients have scalp psoriasis • Visible psoriasis has far greater psychological impact • Active scalp psoriasis increases chance of face psoriasis • Combination treatment often helpful
Slide 10: Facial Psoriasis
FACIAL PSORIASIS • Particularly upsetting for patients • Should we use off–license treatments?