Slide 1: Proteus: The Future of Single-molecule Protein Sequencing
1 ProteusTM The Future of Single-molecule Protein Sequencing World HUPO 2026 Exhibit 99.1
Slide 2: Disclaimer and Other Information
2 Disclaimer and Other Information Forward-looking Statements This presentation includes “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. The actual results of the Company may differ from its expect
Slide 3: Proteus Next-generation Architecture
3 Proteus Next-generation Architecture Platinum® Pro & 2M Chip • Integrated semiconductor consumable with 2 million wells • Benchtop instrument with manual workflow Proteus & Nanowell Array • Simple, passive consumable with estimated 80 million wells at launch • Benchtop instrument with imaging syst
Slide 4: Proteus System Overview
4 Proteus System Overview Nanowell Array Tips Reagents Proteus*: 17.8" wide, 27.1" tall, 27.3" deep *Proteus is in development. Estimated dimensions subject to change.
Slide 5: The Proteus Nanowell Array Enables a Broad Range of Applications
5 The Proteus Nanowell Array Enables a Broad Range of Applications More samples per run with 40× more nanowell capacity per consumable compared to Platinum Pro Deep analysis of a single sample to address complex mixtures or rare events like protein variants or post-translational modifications (PTMs)
Slide 6: Proteus vs Platinum Interim Development Results
Proteus vs Platinum Interim Development Results
Slide 7: Platform Background Information
7 Platform Background Information Platinum Pro is a commercially available system, used here as the reference Proteus instrument, consumables, loading protocol and analysis software are in development and will continue to be improved. Data generated uses a developmental kit that detects 18 Amino Aci
Slide 8: Consumable Configuration & Definitions
8 Consumable Configuration & Definitions *Proteus is in development. Estimated wells. All studies compared using ~1M Platinum Pro chamber to a ~20M Proteus chamber
Slide 9: Study Design & Purpose
9 Study Design & Purpose Control Peptide Mix Purpose • Evaluate fundamental performance characteristics of platform independent of sample preparation Materials • 6 unique control peptides • Each 25 amino acids (AA) in length • Pooled into a single “sample” with equal concentration per peptide • N =
Slide 10: Control Peptides Interim Development Results
Control Peptides Interim Development Results
Slide 11: Proteus delivers 30× more alignments from a single chamber run
11 1 · Platinum 164,493 2 · Platinum 156,349 3 · Platinum 115,454 4 · Platinum 111,778 1 · Proteus 4,432,569 2 · Proteus 4,364,311 3 · Proteus 3,546,412 4 · Proteus 3,824,511 0 4.5 M 30.1× median reported alignments 4,094,411 Proteus median 135,901.5 Platinum median Proteus delivers 30× more alignme
Slide 12: Proteus identifies all 6 peptides in every run
12 Platinum 1 1 3 / 6 Platinum 2 3 / 6 Platinum 3 4 / 6 Platinum 4 5 / 6 Proteus 1 6 / 6 Proteus 2 6 / 6 Proteus 3 6 / 6 Proteus 4 6 / 6 Source: 25merV2 primary & peptide alignment study. Proteus identifies all 6 peptides in every run
Slide 13: Proteus has a 4.8x lower false discovery rate
13 0% 6% 12% 18% 6.95 C1 4.67 C2 16.32 C3 6.21 C4 1.39 P1 1.33 P2 2.85 P3 1.30 P4 Platinum Proteus 1.36% Proteus median FDR Proteus has a 4.8x lower false discovery rate (FDR) Source: 25merV2 primary & peptide alignment study.
Slide 14: ~60× more alignments per instrument run
14 Platinum 2 chambers Chamber 1 0.136 M Chamber 2 0.136 M = 0.27 M Proteus 4 chambers Chamber 1 4.09 M Chamber 2 4.09 M Chamber 3 4.09 M Chamber 4 4.09 M = 16.4 M Each chamber assumed to perform like the single-chamber median ~60× more alignments per instrument run Proteus vs. PlatinumProteus (4 ch
Slide 15: Proteus is a fundamentally superior platform technology
15 S EQ U E N C I N G S C A L E 21.2× median apertures per chamber C L EA N E R S I G N A L 87.2% Pass filter vs 65.6% Platinum C O N V E R S I O N 1.41× more alignments per aperture H I G H E R AC C U R AC Y 1.36% median FDR vs 6.58% Platinum O U TC O M E ~30× per chamber Source: 25merV2 primary &
Slide 16: Protein Mixtures Interim Development Results
Protein Mixtures Interim Development Results
Slide 17: Proteus detected 1.6–2.0× more peptides than Platinum
17 Proteus detected 1.6–2.0× more peptides than Platinum from single chamber runs Source: Protein-mix libraries, Proteus (KDB 8.1.1) vs Platinum (KDB 7.0.0). 0 50 100 150 35 9 44 35 36 71 10-plex · 1.6× 44 22 66 44 90 134 24-plex · 2.0× Platinum only Proteus only Both 1.6–2.0× more peptides identifi
Slide 18: Peptides identified and why Platinum missed the Proteus-only set
18 Peptides identified (FDR ≤ 0.1 and ≥10 alignments), and why Platinum missed the Proteus-only set 10-plex Proteins previously sequenced on Platinum P E P T I D E S I D E N T I F I E D 9 35 36 Platinum only Shared Proteus only W H Y P L AT I N U M M I S S E D T H E 3 6 P R O T E U S - O N LY Low co
Slide 19: Proteus delivers 4.3× greater coverage in a 24 plex protein mixture
19 Proteins detected 1.2× 20.3 Platinum 24.0 Proteus Unique peptides per protein 1.7× 2.46 Platinum 4.09 Proteus Total peptides 2.0× 66 Platinum 134 Proteus Amino acids detected 4.3× 63,366 Platinum 269,864 Proteus 24 / 24 proteins detected on Proteus vs 20.3 on Platinum S E Q U E N C E C O V E R A
Slide 20: Proteus developmental sequencing kit has superior coverage across all amino acids
20 Median fold change in per-residue detection (≥10 alignments), Proteus vs Platinum median of the same residue; 24 plex C and H detected only on Proteus K Recognition is enabled on Proteus but not present in data given LysC conjugation chemistry was used for this study Proteus developmental sequenc
Slide 21: Proteus launch on track for Q2 2027
21*Proteus is in development. Estimated launch specifications. Continue to expand amino acid coverage and demonstrate detection of all 20 AAs by end of 2026 Optimize performance of automated workflow(s) across sample types and applications Complete development of new AI based algorithms to deliver r