Slide 1: Corporate Presentation August 2024
Corporate Presentation augusT 2024 Exhibit 99.2
Slide 2: Disclaimer
Disclaimer The following presentation, including any printed or electronic copy of these slides, the talks given by the presenters, the information communicated during any delivery of the presentation and any question and answer session and any document or material distributed at or in connection wi
Slide 3: Develop and launch the first curative targeted cellular therapies for autoimmune diseases
Develop and launch the first curative targeted cellular therapies for patients with autoimmune diseases
Slide 4: Realizing the vision to transform autoimmune disease treatment
Realizing the vision to transform autoimmune disease treatment 1H24: Reported initial myositis & SLE clinical data at EULAR2 Evaluating CABA-201 without preconditioning Advancing program to potentially eliminate apheresis Securing scalable commercial manufacturing Cash runway into 1H26 Engineered CA
Slide 5: Innovative and scalable clinical strategy with potential for accelerated development path
Innovative and scalable clinical strategy with potential for accelerated development path Pipeline targeting autoimmune diseases with high unmet need Program Trial Preclinical Phase 1/2 Pivotal CABA-201 4-1BB CD19-CAR T RESET-Myositis™ CARTA Chimeric Antigen Receptor T cells for Autoimmunity RESET-S
Slide 6: Chimeric Antigen Receptor T Cells for Autoimmunity CABA-201
Chimeric Antigen Receptor T Cells for Autoimmunity CABA-201
Slide 7: CABA-201: CD19-CAR T specifically designed for autoimmunity
Cabaletta’s CD19 binder with similar in vitro & in vivo activity to FMC631,2 (binder used in academic report3) CABA-201: CD19-CAR T specifically designed for autoimmunity IIT – Investigator-initiated trial; Flu/Cy – Fludarabine/Cyclophosphamide Peng, Binghao J, et al. “Preclinical specificity and ac
Slide 8: SLE & myositis trials enrolling, with a broadening portfolio for CABA-201
SLE & myositis trials currently enrolling, with a broadening portfolio to realize the potential of CABA-201 REstoring SElf-Tolerance (RESET™) Phase 1/2 trials advancing SLE – Systemic lupus erythematosus; DM – Dermatomyositis; SSc – Systemic sclerosis; gMG – Generalized myasthenia gravis; ESRD – End
Slide 9: Broad investigation of CABA-201 in well-defined patient populations
Broad investigation of CABA-201 in well-defined patient populations with the same dose & similar design Clinical strategy to reduce risk, maximize reach & accelerate timelines SLE – Systemic lupus erythematosus; SSc – Systemic sclerosis; gMG – Generalized myasthenia gravis; ASyS – Anti-synthetase sy
Slide 10: RESET-Myositis Phase 1/2 study design
Initial data presented at EULAR 2024 Congress; enrolling patients with active myositis with DM, ASyS or IMNM RESET-Myositis™: Phase 1/2 study design for CABA-201 IIM – Idiopathic inflammatory myopathy; DM – Dermatomyositis; ASyS – Anti-synthetase syndrome; IMNM – Immune-mediated necrotizing myopathy
Slide 11: RESET-SLE Phase 1/2 study design
Initial data presented at EULAR 2024 Congress; enrolling patients with active SLE with or without renal disease RESET-SLE™: Phase 1/2 study design for CABA-201 SLE – Systemic lupus erythematosus; SSc – Systemic sclerosis; gMG – Generalized myasthenia gravis Subjects will be treated with a standard p
Slide 12: Evaluating CABA-201 without preconditioning in pemphigus
Evaluating CABA-201 without preconditioning in pemphigus DSG – Desmoglein; PV – Pemphigus vulgaris Cohen, Adam D., et al. "B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma." The Journal of Clinical Investigation 129.6 (2019). Schmidt, Enno, et al. "Novel ELISA
Slide 13: Translational & clinical parameters inform framework to evaluate advanced modalities in autoimmunity
Time to B cell repopulation B cell phenotype3 Autoantibody changes Durability of clinical activity Rate & severity of infection Delayed cytopenias Chronic maintenance / concomitant medications, if any Up to 12+ months Translational & clinical parameters inform framework to evaluate advanced modaliti
Slide 14: CABA-201 exhibited anticipated profile of expansion and contraction
CABA-201 exhibited anticipated profile of expansion and contraction1 CABA-201 demonstrated expansion & targeted B cell depletion Response appears to be consistent with published data of cryopreserved CAR T products as well as the expansion profile of BCMA-CAR T products in patients with multiple mye
Slide 15: Antibody reduction & clinical improvement in disease activity
Antibody reduction & clinical improvement in disease activity observed with follow-up of 12 weeks1 CK reduction & clinical improvement observed in SRP IMNM Data cut-off as of May 28, 2024. Luminex assay developed and performed by Cabaletta Labs. Qualitative commercial assay (Myositis Antigen Panel,
Slide 16: Early efficacy signals in first patient in non-renal SLE cohort
0 0 Month 3 Month 6 SLEDAI-2K Score 25 20 30 10 5 15 Academic published data for illustrative purposes Trend toward improvement in disease manifestations observed with follow up of 4 weeks2 Early efficacy signals in first patient in non-renal SLE cohort1 Patient in non-renal SLE cohort due to isolat
Slide 17: Initial patient phenotyping data consistent with potential immune system reset
BAFF B cells Preconditioning CABA-201 infusion Initial patient phenotyping data consistent with potential immune system reset; confirmatory analyses ongoing Naïve B cell repopulation occurred at 2 months in first IMNM patient Note: Flow plot gating reflects CD19+ CD20+ live lymphocytes. Data cut-off
Slide 18: Staged approach allows efficient allocation of capital with experienced partners
Staged approach allows for efficient allocation of capital while leveraging experienced partners Manufacturing strategy Late Phase & Commercial: Scale-Up & Commercialization Data-gated, staged investment Early Phase: Penn, CDMOs & CABA Process Ongoing Penn has reliably provided timely product for ye
Slide 19: Securing & expanding our leadership in autoimmune cell therapy
Securing & expanding our leadership in autoimmune cell therapy Myositis Systemic lupus erythematosus Systemic sclerosis Generalized myasthenia gravis Pemphigus vulgaris Minimizing the requirement for inpatient stay Evaluating CABA-201 without preconditioning Seeking to remove the burden of apheresis
Slide 20: Corporate Summary
Corporate Summary Cabaletta Bio”
Slide 21: Track record of operational success evaluating novel cell therapy candidates in autoimmunity
Track record of operational success evaluating novel cell therapy candidates in autoimmunity Cabaletta Bio leadership LEADERSHIP TEAM Anup Marda Chief Financial Officer Arun Das, M.D. Chief Business Officer David J. Chang, M.D., M.P.H., FACR Chief Medical Officer Martha O’Connor Chief HR Officer Mic
Slide 22: Realizing the vision to transform autoimmune disease treatment
Realizing the vision to transform autoimmune disease treatment 1H24: Reported initial myositis & SLE clinical data at EULAR2 Evaluating CABA-201 without preconditioning Advancing program to potentially eliminate apheresis Securing scalable commercial manufacturing Cash runway into 1H26 Engineered CA
Slide 23: Corporate Presentation AUGUST 2024
Corporate Presentation AUGUST 2024