Heartflow, Inc. · NASDAQ:HTFL
Heartflow — Technical Presentation
14 slides from Heartflow's technical presentation
Slide 1: Benefits of Obtaining information for planning With noninvasive FFRCT prior to Invasive Evaluation - The BOWIE study
Benefits of Obtaining information for planning With noninvasive FFRCT prior to Invasive Evaluation- The BOWIE study Eric Van Belle, MD PhD, Luis Raposo MD, Sergio Bravo Baptista MD PhD, Flavien Vincent, MD PhD, Sina Porouchani MD, Alessandro Cosenza MD, Campbell Rogers MD, Jonathon Leipsic MD
Slide 2: Background
Background • Despite an apparently well-conducted PCI procedure, ischemia is not relieved in 15- 30% of patients and is associated with a 3-fold increase of MACE.1,2. • Ideally, this issue should be identified up-front, in order to adapt the procedure and achieve a proper relief of ischemia. • FFRCT
Slide 3: Study Aims
Study Aims To determine the impact of the interactive FFRCT planner, as compared to Invasive Coronary Angiography (ICA) alone, on CAD treatment decision making. • Primary Endpoint: Reclassification Differences between the ICA-based and FFRCT– based treatment plans per patient, per vessel, and per le
Slide 4: What is FFRCT Planner?
What is FFRCT Planner ? * Pre-procedure evaluation of alternate treatment strategies to optimize coronary flow • Real-time non-invasive interactive tool • Explore different clinical scenarios by virtually removing stenoses • Assess resulting FFRCT value(s) from any scenario * N ot yet com m ercia ll
Slide 5: FFRCT Planner Core Components
FFRCT Planner Core Components * 1 Starts with the HeartFlow Analysis Interactive Mobile Platform 2 ● iOS, interactive viewer HeartFlow Planner 3 Ideal Geometry Real-time FFRCT calculation 4 ● Contains a second anatomic model ● Modified vessel combined with updated representing the “ideal” vessel phy
Slide 6: Study design: reclassification
8 patients (7%) excluded due to poor ICA image quality 109 patients with CAD and available CTA, FFRCT, 101 patients (n=327 lesions) and ICA Invasive Coronary Angiography Consensus ICA Management Plan evaluated independently by 3 per lesion, per vessel, and per patient interventional cardiologists OM
Slide 7: Results: anatomical and physiological disease burden
Results: anatomical and physiological disease burden • 101 patients, 327 stenoses • Mean number of stenoses: 3.2 ± 1.6 per patient • Serial stenoses (≥ 2 lesions in a row in the same territory) were present in 81% on ICA • Baseline distal FFRCT values were lower in LAD, as compared with LCX and RCA
Slide 8: Reclassification rates per lesion and per patient
Reclassification rates per lesion and per patient Lesion level (n=327) Patient level (n=101) 31% 45% 55% 69% No Reclassification Reclassified by FFRCT Planner
Slide 9: Reclassification rates by lesion complexity
Reclassification rates by lesion complexity Single Lesion Serial Lesions 34% 36% 64% 66% No Reclassification Reclassified by FFRCT Planner
Slide 10: Change of physiology usage by FFRCT Planner
Change of physiology usage by FFRCT Planner 4% 19,5 %
Slide 11: Impact of FFRCT Planner: Lesion-level reclassification
Impact of FFRCT Planner: Lesion-level reclassification ICA-Guided Management Plan FFRCT Planner-Guided Management Plan Optimal Medical Therapy (OMT) n=84 lesions Optimal Medical Therapy (OMT) n=113 lesions FFRCT Planner Invasive FFR Needed n=113 lesions Invasive FFR Needed n=62 lesions PCI n=105 les
Slide 12: Reclassification rates by ICA-based management plan
Reclassification rates by ICA-based management plan ICA-based plan: PCI (n=66) No Revasc (n=28) CABG (n=7) 40% 43% 46% 60% 54% 57% No Reclassification Reclassified by FFRCT Planner
Slide 13: Non-invasive interactive FFRCT Planner reclassifies the PCI strategy
Non-invasive interactive FFRCT Planner reclassifies the “PCI strategy” ICA FFRCT Planner Pre-PCI Reduced stent length using FFRCT ICA-based plan 38mm stent Baseline FFRCT Planner strategy yielded similar physiologic result as ICA-based plan Post-PCI ICA-based plan reproduced on FFRCT Planner FFRCT P
Slide 14: Summary
Summary • In patients with coronary artery disease, the use of the interactive FFRCT planner prior to invasive angiography may: • Change the revascularization strategy in 31% of lesions and 45% of patients • Reduce the need for invasive physiology • Not reduce the rate of PCI but change the PCI stra