Faron Pharmaceuticals Oy · LSE:FARN
Faron Pharmaceuticals Oy — Shareholder Meeting (May 2020)
25 slides from Faron Pharmaceuticals Oy's shareholder meeting presentation, May 18, 2020
Slide 1: Faron Pharmaceuticals AGM Presentation, 18 May 2020
Faron Pharmaceuticals (LSE AIM: FARN, NASDAQ Helsinki: FARON) AGM Presentation, 18 May 2020 CEO Markku Jalkanen
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Slide 3: Faron's pipeline is based on receptors involved in regulation of immune responses
FARON’S PIPELINE IS BASED ON RECEPTORS INVOLVED IN THE REGULATION OF IMMUNE RESPONSES & VASCULAR DYSFUNCTIONS Immuno-Oncology ARDS & Organ protection Clevegen® Clever-1 regulates tissue immune status Traumakine® CD73 controls capillary leakage and escalation of inflammation AOC3 escalates inflammati
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Slide 7: Turn on your immunity: Clevegen
te Turn on your immunity F (cievecen
Slide 8: Macrophages as generals of anti-tumor immunity
MACROPHAGES AS GENERALS OF ANTI-TUMOR IMMUNITY Pro-tumor (M2) Class Anti-tumor (M1) etching IL-10, TGFB 1L-12, TNFa Low MHCII High MHCII M2 macrophages are ... while M1 macrophages immunosuppressive... are immuno stimulatory Coss | cos [alee
Slide 9: Clevegen - the immune switch
Cancer cell Only activation of adaptive immunity can fight cancer Clevegen - the QF immune switch « SN een - > Ye oe Cancer cell
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Slide 13: Increasing number of responding cancers
INCREASING NUMBER OF RESPONDING CANCERS Colorectal cancer Cutaneous melanoma 6 weeks Note the clearance of pleural effusion Arrows point shrinking lung metastasis (red circle). Treatment initiated after in MSI low CRC patient. Treatment four lines of therapy including initiated after six lines of th
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Slide 18: Traumakine
TRAUMAKINE
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Slide 20: Survival (%)
( %$ #$)" 6<$ 5:)#*## ")##$'" %!# %!' !!!%- 100 "+!!)7/1& ..* !!%26 75 A4,45/6<)0 !"& !!!!)703& ./* (! $ ! Survival (%) !!%/.6 "!!!%$! 50 !# %! 25 Untreated Treated p=0·01 A4,45 0 0 5 10 15 20 25 30 !% " !# %! $"" $*# #$)!" " %#'$ "$$)$#( $#'# '"$(!$ !$$#' "' !" &$%%$ %$ ####$# !$$ "$ ##$# '$!" &$%%
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Slide 22: IFN beta-1a treatment arm
IFN beta-1a treatment arm Glucocorticoids on D0– D6 !!
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Slide 25: Thank You
” FARON Thank You “Our world is built on biology. Once we begin to understand our biology, it then becomes a technology
Faron Pharmaceuticals — Shareholder Meeting (May 2020) on 6ix