Egetis Therapeutics Ab · OMXSTO:EGTX

Egetis Therapeutics Ab — Investor Presentation (October 2023)

81 slides from Egetis Therapeutics Ab's investor presentation, October 2023

  1. Slide 1: We Care for the Rare – Corporate presentation October 2023

    WE CARE FOR THE RARE Corporate presentation October 2023 An integrated orphan drug company, focusing on late-stage development for commercialization

  2. Slide 2: Disclaimer

    Disclaimer THIS PRESENTATION AND ITS CONTENTS ARE NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN OR INTO OR FROM THE UNITED STATES OF AMERICA, CANADA, AUSTRALIA, JAPAN OR ANY JURISDICTION WHERE SUCH DISTRIBUTION IS UNLAWFUL. IMPORTANT: You must read the

  3. Slide 3: Agenda

    Agenda 1. An integrated orphan drug company, focusing on late-stage development for commercialization 2. Emcitate - Overview of MCT8-deficiency - Clinical experience with Emcitate - Regulatory pathway to submissions in EU and US - Commercial opportunity 3. Aladote* - Paracetamol/Acetaminophen overdo

  4. Slide 4: An integrated orphan drug company, focusing on late-stage development for commercialization

    WE CARE FOR THE RARE 1. An integrated orphan drug company, focusing on late-stage development for commercialization

  5. Slide 5: An integrated orphan drug company, focusing on late-stage development for commercialization

    An integrated orphan drug company, focusing on late-stage development for commercialization Dedicated orphan drug company 1 Two late-stage assets: Emcitate and Aladote* 2 Emcitate MAA filed in October 2023 Target Emcitate NDA 2024 3 Highly attractive orphan drug segment Plan to launch through small

  6. Slide 6: Building a sustainable orphan drug company

    WE CARE Building a sustainable orphan drug company FOR THE RARE • Successfully develop Emcitate for EU submission in 2023 and US submission in 2024; Aladote post 2026 • Commercialize Emcitate and Aladote through an inhouse organization in Europe/ North America and partnerships in RoW • Realize the f

  7. Slide 7: Termination of discussions regarding a potential acquisition of the Company

    Termination of discussions regarding a potential acquisition of the Company Announcement published on May 23, 2023 • Discussions, triggered by an unsolicited approach by an external party, have taken place between certain external parties and Egetis regarding a potential acquisition of the Company •

  8. Slide 8: Orphan drug segment – a highly attractive opportunity

    Orphan drug segment – a highly attractive opportunity Shorter clinical development time1 Higher attainable prices2 Orphan drugs attractive returns5 Phase II to launch Average # of years Mean cost per patient and year (USDk) 143,4 152,2 150,9 128,1 134,5 ORPHAN 3.8 years 1.7x 10,3% 31,2 32,4 33,7 NON

  9. Slide 9: Pipeline overview

    Pipeline overview Planned Emcitate EU filing in 2023 and US filing in 2024 Candidate Preclinical Phase I Phase II/III MAA/NDA Comments Emcitate EU MCT8 deficiency Filed Oct 2023 - All clinical data available for submission Emcitate US - 16 patients, 30-day randomized trial MCT8 deficiency ReTRIACt m

  10. Slide 10: Two highly promising orphan drug candidates

    Two highly promising orphan drug candidates Aladote® – To prevent acute liver injury caused by Emcitate® – Therapy for MCT8 deficiency paracetamol poisoning • MCT8 deficiency affects ~1:70,000 males: high unmet medical need, no • Paracetamol poisoning is one of the most common overdoses with availab

  11. Slide 11: Commercialisation of Emcitate & Aladote

    Commercialisation of Emcitate & Aladote Commercial infrastructure build up initiated Strong success factors… …for sustainable, profitable & lean commercialisation 1 High unmet medical need without competing compounds • Building inhouse commercial capabilities for launch of Emcitate® and Aladote® in

  12. Slide 12: Overview of MCT8 deficiency

    2. Overview of MCT8 deficiency 12

  13. Slide 13: MCT8 deficient patients

    MCT8 deficiency results in dysfunctional thyroid hormone trafficking MCT8 deficiency has two co-manifestations MCT8 deficiency results in simultaneous too high and too low New Research Sheds Light on Thyroid Hormone Transport thyroid hormone levels – causing system wide issues • In 2002 the first th

  14. Slide 14: MCT8 deficiency: a detrimental condition with significant unmet medical need

    MCT8 deficiency: a detrimental condition with significant unmet medical need What is MCT8 deficiency? What does it mean? What are the challenges? How do you manage the Quick facts from natural history2 disease? • Genetic X-linked disorder ● Non-functional MCT8 protein: ● Patients appear normal at bi

  15. Slide 15: Natural history study revealed poor survival with treatable risk factors

    Natural history study revealed poor survival with a high prevalence of treatable underlying risk factors An international, retrospective, multicentre cohort study from 2014-2020 in 151 patients • 151 patients were enrolled with 73 different MCT8 (SLC16A2) mutations • Median age at diagnosis was 24.0

  16. Slide 16: Multiple sources lead to consistent MCT8 deficiency incidence estimates

    Multiple sources lead to consistent MCT8 deficiency incidence estimates Available Data Leads to Consistent Supporting our Relevant Sources & Data MCT8 Deficiency Incidence Estimates Conservative Estimate • Multiple cohorts of patients with X- linked mental retardation under study Visser et al., Clin

  17. Slide 17: Clinical experience with Emcitate

    2. Clinical experience with Emcitate 17

  18. Slide 18: Orphan drug candidate

    Orphan drug candidate with clear scientific and mechanistic rationale and established safety profile Difference normal MCT8 and deficiency of MCT8 Emcitate (tiratricol) – Addressing MCT8 deficiency • Thyroid hormone T3 requires transporters such as MCT8 • Tiratricol is a small molecule thyroid hormo

  19. Slide 19: Emcitate Overview

    Emcitate® Overview Lead candidate for addressing MCT8 deficiency, a condition with high unmet medical need and no available treatment • Triac Trial I completed with significant and clinically relevant effects • Erasmus Medical Center cohort study confirms long-term efficacy and safety for up to 6 ye

  20. Slide 20: Overview of completed Phase IIb – Triac Trial I

    Overview of completed Phase IIb – Triac Trial I • Evaluate the efficacy and safety of oral administration of tiratricol in male patients with MCT8 deficiency of all ages Primary objective and • Highly significant primary outcome - Change in T3 serum concentrations results • Safe and tolerable • Resu

  21. Slide 21: Consistent, clinically relevant and highly significant results

    Consistent, clinically relevant and highly significant results Triac Trial I: Reached target level serum T3 & improvements in clinically relevant outcome measures 10 T0 (Baseline) 8 T12 (12 month) p < 0.0001 Serum T3 (nmol/l) 6 4 2 Normal range 0 Endpoints Baseline mean (± SD) 12 months mean (± SD)

  22. Slide 22: Triac Trial I: Indication of positive effect on neurocognitive development

    Triac Trial I: Indication of positive effect on neurocognitive development In the youngest patients which is further studied in ongoing, fully recruited, Triac Trial II 40 T0 (Baseline) T12 (12 months) 30 GMFM score (%)1) 20 10 0 # # # Patients 1.5 to <4 years 4 to <10 years ≥10 years Age at baselin

  23. Slide 23: Long-term efficacy and safety of Emcitate in MCT8 deficiency patients

    Long-term efficacy and safety of Emcitate® in MCT8 deficiency patients Published in October, 2021 • Investigator-initiated real-world cohort study at 33 sites conducted by the Erasmus Medical Center • Investigated efficacy and safety of Emcitate in 67 patients with MCT8 deficiency ‒ Median baseline

  24. Slide 24: New patient cohort of equal size to the Triac Trial I

    New patient cohort of equal size to the Triac Trial I Long term follow up, up to >6 years Triac Trial I N=46 Triac Trial I patients New patients Available for long-term From named patient program monitoring N=40 N=27 EMC cohort Published in JCEM N=67 Corporate presentation | Egetis Therapeutics | 20

  25. Slide 25: New cohort confirms primary endpoint results in Triac Trial I

    New cohort confirms primary endpoint results in Triac Trial I Fast and durable normalization of T3 values in almost all patients p<0.0001 Corporate presentation | Egetis Therapeutics | 2023-10-22 25

  26. Slide 26: Consistent, clinically relevant and highly significant results across endpoints

    Consistent, clinically relevant and highly significant results across endpoints • Data confirm the positive results from previous study, Triac Trial I • Normalization of serum T3 corresponds to improvement in thyroid hormone status in end target tissues • Beneficial effects are maintained or continu

  27. Slide 27: Emcitate regulatory pathway to submissions in EU and US

    2. Emcitate® - regulatory pathway to submissions in EU and US Corporate presentation | Egetis Therapeutics | 2023-10-22 27

  28. Slide 28: Regulatory features of Emcitate for MCT8 deficiency

    Regulatory features of Emcitate for MCT8 deficiency Orphan drug designation for MCT8 deficiency ODD Eligibility: Market exclusivity 10y (EU) & 7y (US) Fast Fast track designation (FDA) track Eligibility: Six months review of NDA & rolling submission Rare pediatric disease designation (FDA) PRV Eligi

  29. Slide 29: Emcitate regulatory pathway to submissions in EU and US

    Emcitate regulatory pathway to submissions in EU and US The first potential treatment for MCT8 deficiency, an ultra rare genetic disease with high unmet medical need and no available treatment Included in MAA in EU submitted on October 9, 2023 Not required for MAA or Included in NDA in US mid 2024 u

  30. Slide 30: Egetis submitted MAA for Emcitate to EMA on October 9, 2023

    Egetis submitted MAA for Emcitate® to EMA on October 9, 2023, based on existing clinical data • Based on regulatory interactions, Egetis concludes that available data from Triac Trial I and recently published long-term data are sufficient for a Marketing Authorisation Application (MAA) in Europe • H

  31. Slide 31: Content in Emcitate MAA submission

    Content in Emcitate MAA submission • Regulatory submissions in major regions contain the same type of key information on Efficacy, Safety and Quality ‒ presented in a common format (called CTD - Common Technical Document) Common technical document Key components of regulatory dossier Clinical data N

  32. Slide 32: Treatment effects on T3 levels could provide basis for US approval

    Treatment effects on T3 levels in MCT8-deficiency could provide a basis for marketing approval in the US – NDA targeted in mid 2024 • FDA acknowledges that a treatment effect on T3 levels and the manifestations of chronic thyrotoxicosis in MCT8-deficiency could provide a basis for marketing approval

  33. Slide 33: ReTRIACt: withdrawal of Emcitate in males with MCT8 Deficiency

    ReTRIACt: withdrawal of Emcitate in males with MCT8 Deficiency Pivotal randomized placebo-controlled trial for NDA submission • Proportion of participants who meet the rescue criterion (serum total T3 > ULN) Primary during the 30-day double-blind Randomized Treatment Period endpoint • Change in card

  34. Slide 34: ReTRIACt – A randomized placebo-controlled withdrawal study

    ReTRIACt – A randomized placebo-controlled withdrawal study designed to show an effect on the proportion of patients needing rescue treatment Verifying previous results in single arm Triac Trial I and a real-world cohort study • A 30-day, placebo-controlled withdrawal study in 16 treated patients, t

  35. Slide 35: Availability of patients at study sites in ReTRIACt

    Availability of patients at study sites in ReTRIACt Map not to scale University Hospital St Jan University Erasmus Hospital Brussels Medical Centre Current availability of patients for ReTRIACt OHSU CHOP Addenbrooke’s Hospital Charité Berlin Charles University Hôpital Universitaire Necker-Enfants Ma

  36. Slide 36: Triac Trial II fully recruited: early intervention on neurocognitive development

    Triac Trial II fully recruited: to establish effects of early intervention on neurocognitive development Market approval not dependent on Triac Trial II data • Confirm findings from Triac Trial I in youngest age group Primary Objective • Improvement in neurocognitive development as measured by GMFM1

  37. Slide 37: Upcoming pipeline milestones

    Upcoming pipeline milestones • Results ReTRIACt for US NDA • Filing US NDA mid ‘24 under Fast Track Designation • Results Triac Trial II ✓ US & EU ODD RTH-b ✓ FPI ReTRIACt for US NDA • EU approval and launch Emcitate® ✓ Recruitment completed in ✓ Filing EU MAA Oct 9, ‘23 • US approval and launch Tri

  38. Slide 38: FDA granted Rare Pediatric Disease designation to Emcitate

    FDA granted Rare Pediatric Disease designation to Emcitate® US Rare Pediatric Disease Priority Review Voucher (PRV) provides a ~$100m opportunity Overview of PRV Examples of PRVs sold Seller Buyer Value Year • The FDA grants Rare Pediatric Disease designation (RPD) to therapies for serious or life-t

  39. Slide 39: Emcitate - Commercial opportunity

    2. Emcitate® - Commercial opportunity 39

  40. Slide 40: Emcitate – alleviating patient and societal burden

    Emcitate®– alleviating patient and societal burden Aiming to provide value for both patients and society MCT8 deficiency is a detrimental condition with significant unmet medical need and no approved therapy • Median life-expectancy of MCT8 patients is 35 years1 Patients • Patients underweight for a

  41. Slide 41: Emcitate supplied globally on a named patient basis

    Emcitate supplied globally on a named patient basis The named patient use (NPU) confirms the significant unmet medical need in MCT8 deficiency and the view on how Emcitate address it • NPU and compassionate use programs MEDICINES AGENCY ‒ mechanisms to allow early access to a medicine prior to regul

  42. Slide 42: Commercialization of Emcitate

    Commercialization of Emcitate Disease area conditions provide opportunity for lean commercialization Favorable conditions for launch success Stepwise establishing in-house commercial capabilities Addressing unmet medical need • Preparing for 2024-25 launches in Europe and US, respectively • Commerci

  43. Slide 43: Building commercial organization for launch success

    Building commercial organization to execute on key activities at the right time for launch success Key projects driven by recognized industry talents recruited to the Egetis Commercial & Medical Affairs Team – Leadership team brings launch skills and best practices from in total 100+ years at intern

  44. Slide 44: Focusing on Critical Areas for Launch Success

    Focusing on Critical Areas for Launch Success Aiming to Improve the Lives of MCT8 Deficiency Patients and their Caregivers IDENTIFY PATIENTS ENSURE ACCESS Boost disease awareness, educate on Preparing for broad access to Emcitate as disease*, diagnosis and newborn soon as possible after marketing sc

  45. Slide 45: Disease awareness initiatives are bearing fruit

    Disease awareness initiatives are bearing fruit • Awareness of MCT8 deficiency remains low also among specialists, with DISEASE AWARENESS a high proportion of patients living without correct diagnosis AND EDUCATION • Increasing disease awareness and facilitating diagnostic testing are key strategic

  46. Slide 46: Aiming for broad access to Emcitate for affected families

    Aiming for broad access to Emcitate for affected families Payer projects initiated to generate optimal reimbursed price – No families should pay out of own pocket • Payers in general accept higher prices for • Emcitate fulfills these criteria, no other drugs orphan drugs compared to traditional drug

  47. Slide 47: Developing Emcitate clinical and economic value proposition

    Developing a compelling Emcitate clinical and economic value proposition to secure reimbursement & access Key for payer assessments to describe unmet need & quantify burden of MCT8 deficiency • The impact of MCT8 deficiency on patients and caregivers is underreported • Significant clinical and econo

  48. Slide 48: Exclusive Distribution Model Through Speciality Pharmacy

    Exclusive Distribution Model Through Speciality Pharmacy is Preferred option for Rare Disease • Insurance resolution and contracting • Prior authorization support • Appeals • Dedicated case managers • Improves patient experience and outcomes • Patient Assistance and Copay Support 48

  49. Slide 49: US Pricing & Reimbursement

    US Pricing & Reimbursement Relatively straight forward for ultra-orphans with key focus on rarity and severity of disease Analogues selected based on: Emcitate’s value drivers confirmed by US payer research: • Rarity (ultra-orphan) • Paediatric “You have all the things “The product gets paid for “If

  50. Slide 50: Paracetamol/Acetaminophen overdose and clinical experience with Aladote

    3. Paracetamol/Acetaminophen overdose and clinical experience with Aladote 50

  51. Slide 51: Paracetamol/acetaminophen poisoning

    Paracetamol/acetaminophen poisoning – no adequate treatment for increased-risk patients What is • Minimum toxic dose of paracetamol/acetaminophen in adults is only 7.5g paracetamol/ acetaminophen • Risk factors include malnutrition, alcoholism and consumption of other medications poisoning? • Parace

  52. Slide 52: Orphan drug candidate

    Orphan drug candidate with clear scientific and mechanistic rationale Early presenters (<8h) Late presenters (>8h) are at increased-risk for liver injury NAC treatment effective against liver injury NAC treatment + Aladote® to prevent liver injury • Liver glutathione (GSH) replenished by NAC, toxic

  53. Slide 53: Overview of completed Phase Ib/IIa

    Overview of completed Phase Ib/IIa • Met primary endpoint of safety tolerability in the combination of Aladote® and NAC Primary • Results presented at the 58th Annual Meeting of the Society of Toxicology, EASL objective and ILC in April, Vienna and published in Lancet’s journal EBioMedicine in 2019

  54. Slide 54: Positive proof-of-principle Phase Ib/IIa results

    Positive proof-of-principle Phase Ib/IIa results Indicates that Aladote may reduce liver injury Safety & tolerability Liver injury – ALT1 pre-defined secondary outcome NAC + 2 NAC + 5 NAC + 10 NAC + 2 NAC + 5 NAC + 10 % of patients needing mol/kg mol/kg mol/kg mol/kg mol/kg mol/kg additional N

  55. Slide 55: Aladote demonstrates reduced liver injury by exploratory biomarkers

    Aladote® demonstrates consistent results of reduced liver injury as measured by exploratory biomarkers K18K18 ccK18 ccK18 miR-122 miR-122 10 10 10 Relative change from baseline Relative change from baseline Relative change from baseline NAC alone NAC alone NAC alone NAC and 2umol/kg NAC and 2umol/kg

  56. Slide 56: Aladote - Regulatory pathway to submissions in EU and US

    3. Aladote® - Regulatory pathway to submissions in EU and US* * In-house development of Aladote has been parked until Emcitate submissions have been completed Corporate presentation | Egetis Therapeutics | 2023-10-22 56

  57. Slide 57: ALBATROSS: Phase IIb/III study for US/EU regulatory submission

    ALBATROSS: Phase IIb/III study for US/EU regulatory submission • Patients who have overdosed on paracetamol with increased Patient risk of liver damage due to late arrival at hospital (> 8h) who population need treatment with NAC NAC regimen • Approved 21 hours NAC regimen Treatment • 4 groups in co

  58. Slide 58: ALBATROSS: Aladote Phase IIb/III study design

    ALBATROSS: Aladote Phase IIb/III study design Seamless Phase IIb/III design Based on the acetaminophen/paracetamol levels eligible patients will be randomised in a 1:1:1:1 ratio to one of the 4 treatment arms in combination with NAC: 35 35 55 140 pts interim 250 pts 35 analysis 55 35 • Stop the stud

  59. Slide 59: Aladote clinical development timelines

    Aladote clinical development timelines Orphan Drug Designation EU • Interim analysis CTA pivotal • Recruitment completed Phase IIb/III study and topline results 2022 tbc tbc tbc • Start pivotal Phase • Regulatory submissions IIb/III study (after Europe/US Emcitate submissions have been completed) •

  60. Slide 60: Aladote - Commercial opportunity

    3. Aladote® - Commercial opportunity Corporate presentation | Egetis Therapeutics | 2023-10-22 60

  61. Slide 61: Aladote – alleviating patient and societal burden

    Aladote– alleviating patient and societal burden Aiming to provide value for both patients and society POD is a life threatening condition with remaining medical needs • POD (paracetamol/acetaminophen overdose) can lead to acute liver failure, liver transplant or death Patients • In US and UK togeth

  62. Slide 62: Commercialisation of Aladote for high-risk POD patients

    Commercialisation of Aladote for high-risk POD patients Very cost-effective since possible to launch through members of Emcitate team Favorable conditions for launch success Addressing life-threatening condition • Anologue antidotes priced at $3.5k – 50k Addressing unmet medical need • National emer

  63. Slide 63: Analogue antidotes priced at $3.5k – 50k

    Analogue antidotes priced at $ 3.5k – 50k National emergency hospital stocking guidelines - opportunity for rapid market penetration • Various antidotes, e.g. vs. drug overdosing, metal poisoning, snake bites and reversal of anticoagulant treatment effects • Limit morbidity/mortality when used withi

  64. Slide 64: The attractiveness of the orphan drug segment

    4. The attractiveness of the orphan drug segment Corporate presentation | Egetis Therapeutics | 2023-10-22 64

  65. Slide 65: Orphan drug segment – a highly attractive opportunity

    Orphan drug segment – a highly attractive opportunity Orphan drug designation is awarded to • Less extensive clinical trials 1 products targeting limited disease populations1 Development • Agile and faster development process • Lower costs • Lower development risk 2 More than 7,000 known rare diseas

  66. Slide 66: CAGR estimates of total pharmaceutical market vs orphan

    CAGR estimates of total pharmaceutical market vs orphan The global orphan or rare disease market size was valued at an estimated USD 140 – 150 bn and is expected to grow at 10-14% CAGR over the coming five years. Source: EvaluatePharma, Pareto. Corporate presentation | Egetis Therapeutics | 2023-10-

  67. Slide 67: Summary

    5. Summary Corporate presentation | Egetis Therapeutics | 2023-10-22 67

  68. Slide 68: EGTX – a de-risked biotech with substantial unlocked potential

    EGTX – a de-risked biotech with substantial unlocked potential • Late stage biotech “under the radar”, developing the first therapy for a devastating genetic disorder ‒ Strong team with established track record in the orphan drug space, including SOBI, Alexion, Biomarin, Biogen, Vertex, Sarepta, Shi

  69. Slide 69: Two highly promising orphan drug candidates

    Two highly promising orphan drug candidates Aladote® – To prevent acute liver injury caused by Emcitate® – Therapy for MCT8 deficiency paracetamol poisoning • MCT8 deficiency affects ~1:70,000 males: high unmet medical need, no • Paracetamol poisoning is one of the most common overdoses with availab

  70. Slide 70: Upcoming pipeline milestones

    Upcoming pipeline milestones • Results ReTRIACt for US NDA, H1 ‘24 • Filing US NDA mid ‘24 under Fast Track Designation • Results Triac Trial II ✓ US & EU ODD RTH-b ✓ FPI ReTRIACt for US NDA • EU approval and launch Emcitate® ✓ Recruitment completed in ✓ Filing EU MAA Oct 9, ‘23 • US approval and la

  71. Slide 71: An integrated orphan drug company, focusing on late-stage development for commercialization

    An integrated orphan drug company, focusing on late-stage development for commercialization Dedicated orphan drug company 1 Two late-stage assets: Emcitate and Aladote* 2 Emcitate MAA filed in October 2023 Target Emcitate NDA 2024 3 Highly attractive orphan drug segment Plan to launch through small

  72. Slide 72: Appendix

    A. Appendix Corporate presentation | Egetis Therapeutics | 2023-10-22 72

  73. Slide 73: Discovery of Emcitate (Triac, tiratricol)

    Discovery of Emcitate (Triac, tiratricol) T3 Triac (tiratricol)

  74. Slide 74: Resistance to Thyroid Hormone type Beta (RTH-β)

    Resistance to Thyroid Hormone type Beta (RTH-β) Potential indication expansion for Emcitate into non-overlapping patient population Characteristics of RTH-β Emcitate as potential treatment for RTH-β • Caused by mutations in thyroid hormone receptor • Emcitate efficacious in restoring signaling in ma

  75. Slide 75: Leadership team with global experience & proven track record

    Leadership team with global experience & proven track record Nicklas Westerholm Anny Bedard CEO President Egetis North America • Joined 2017; Holds 212,976 shares • Joined 2022; Holds 0 shares • AstraZeneca 1995-2017 • Commercial leadership roles at Shire and Sarepta • VP Late-stage development CVMD

  76. Slide 76: Board of directors

    Board of directors Thomas Lönngren Mats Blom Chair of the board since 2021 Board member since 2021 • Shares in Egetis: 283,158 • Shares in Egetis: 3,134,762 • MSc in social and regulatory pharmacy and a • BA, Business Administration & Economics, Lund degree in Pharmacy, University of Uppsala. Univer

  77. Slide 77: Share Register, Cash and Market Cap

    Share Register, Cash and Market Cap • Cash position: SEK 179M (~EUR 15M)* • Private placement Oct 10, 2023: SEK 172M (gross) • Number of outstanding shares: 292.6M • MCap: ~SEK 1,6 billion** • Listing venue: Nasdaq Stockholm Main Market • Ticker: EGTX Source: Monitor by Modular Finance. Compiled and

  78. Slide 78: Acquisition of Rare Thyroid Therapeutics on 5 November 2020

    Acquisition of Rare Thyroid Therapeutics on 5 November 2020

  79. Slide 79: The combination will drive synergies

    The combination will drive synergies PledPharma and Rare Thyroid Therapeutics merged to launch a new company + = PledPharma Rare Thyroid Therapeutics Synergistic orphan drug focus • Team with profound late-stage drug • Team with strong track-record of identifying • 2020 accelerated PledPharma’s stra

  80. Slide 80: The acquisition and rights issue

    The acquisition and rights issue Institutional investor base broadened Acquisition Rights issue On 5 November 2020, PledPharma Successfully raised SEK 250 million in oversubscribed rights issue acquired all outstanding common shares (c. SEK 200m) and utilized overallotment option (c. SEK 50m) in Rar

  81. Slide 81: Thank you!

    Thank you! Egetis Therapeutics egetis.com karl.hard@egetis.com Corporate presentation | Egetis Therapeutics | 2023-10-22 81

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