Adhera Therapeutics Inc. · OTC:ATRX

Adhera Therapeutics — Marina Biotech — 7th International Conference on Fixed Combination in the Treatment of Hypertension, Dyslip (March 2017)

6 slides from Adhera Therapeutics's conference presentation, Mar 6, 2017

  1. Slide 1: Celecoxib FDCs for the Treatment of Arthritis

    x é “SY MARINA BIOTECH FIXED 5 COMBINATION gta AUTOTELIC INC ~ Celecoxib FDCs for the Treatment of Arthritis Vuong Trieu?, Sanjive Qazi?, Lynne Murphy”, Anshuma Mehta?, Wen Wang?, Mihir Munsif?, Zachary Yim? 1 Autotelic Inc., Costa Mesa, CA, USA 2 Marina Biotech, Agoura Hills, CA, USA Contact email:

  2. Slide 2: Disclosures

    L FIXED COMBINATION Disclosures The Authors are Employees/Shareholders/Board Member of Marina Biotech

  3. Slide 3: Background

    < SMARINA rove COMBINATION ackg un Celecoxib is a highly effective anti-inflammatory drug. However, its use is associated with adverse events including edema and hypertension (HTN). Here we examined the impact of celecoxib intake on HTN and edema. The concomitant intake of celecoxib and one of the a

  4. Slide 4: Patient level data analysis results

    < SMARINA rove Ginewarion Me ent level data analysis results Impact of Celebrex on Change in BP Readings Figure 2 | Figure 2. Changes in Blood Pressure comparing Celebrex alone with Celebrex plus an Anti- Hypertensive. Celebrex alone did not exhibit increases in blood pressure and no definitive tren

  5. Slide 5: Patient level data analysis results

    aL - Here atient level data analysis results COMBINATION -@ *Any -@ Celebrex 40, -@ 17-102 . — 5 3D 20 Fd 2 10: 0. o 80 160 240 320 Days on Celebrex incidence of edema with Celebrex treatment. © +Any © Celebrex 40, @ 11-103 ° ies © E eg 8 20. fi iS ee | 10 0 0 80 160 240320 Days on Celebrex Figure 3

  6. Slide 6: Dissolution profile of celecoxib and lisinopril FDC

    Pa “MARINA = Biatecn AUTOTELIC IN FIXED uswiarion Dissolution profile of | Figure 4. Celecoxib and lisinopril dissolution profiles of the reference listed drug and pilot product restr 20 mg-cN0106A (pH 6.8) (200 celecoxib/20 mg lisinopril FDC bilayer —piotisn (or 6a eninmconaecneass || ae tablet). >

Marina Biotech — 7th International Conference on Fixed Combination in the Treatment of Hypertension, Dyslip (March 2017) on 6ix