Telomir Pharmaceuticals, Inc. · NASDAQ:TELO
Telomir Pharmaceuticals — Corporate Update (April 2024)
31 slides from Telomir Pharmaceuticals's corporate update, Apr 15, 2024
Slide 1: Age Reversal Data Unveiling at the National Press Club
TELOMIR AGE REVERSAL Distinguished Anti-Aging Expert and NYT Bestselling Author Michael F. Roizen, MD will Unveil Groundbreaking Data on promising Age Reversal Drug from Telomir Pharmaceuticals at the National Press Club April 15, 2024 529 14th St NW Washington, DC 20045 TELOMIR
Slide 2: Cautionary Note Regarding Forward-Looking Statements
CAUTIONARY NOTE REGARING FORWARD-LOOKING STATEMENTS TELOMIR AGE REVERSAL This presentation contains forward-looking statements (as defined under the U.S. federal securities laws) of Telomir Pharmaceuticals, Inc. (“we,” “us," or “our”). These statements reflect our current expectations and views of f
Slide 3: Proceedings
PROCEEDINGS TELOMIR AGE REVERSAL Introductions —- Kandi Amelon, Communications Consultant 4/ Telomir Business Overview - Dr. Chris Chapman 6/ Preclinical and Clinical Development - Dr. Chris Chapman 15/ The Science of Telomir - Dr. Michael F. Roizen 29/ The Georgetown Group - Dr. Michael F. Roizen Q
Slide 4: Telomir Pharmaceuticals At-A-Glance
TELOMIR Pharmaceuticals At-A-Glance Founded PN August 2021 Headquarters Baltimore L::| A IPO Date Ha February 9, 2024 Shares Outstanding 29,609,814 Dr. Chris Chapman Nasdaq: TELO TELOMIR AGE REVERSAL ‘Telomir_Pharmaceuticals is a preclinical stage pharmaceutical company focused on the development an
Slide 5: Key Investment Highlights
Key Investment Highlights TELOMIR AGE REVERSAL Treatment Indications — Elongating telomeres, age-related inflammatory diseases (osteoarthritis), and é hemochromatosis. ¢ Large Market Opportunity Osteoarthritis - $7.4 billion worldwide in 2021, expected CAGR of 8.5% through 2030* Global longevity - a
Slide 6: Artificial Intelligence (AI) Modeling of Telomir-1
Artificial Intelligence (Al) Modeling of Telomir-1 TELOMIR: AGE REVERSAL TELOMIR collaborated with InSilicoTrials, an innovator in leveraging Al and simulations to enhance drug development, to perform advanced Al modeling on Telomir-1. Early research has confirmed the mechanism of action of Telomir-
Slide 7: Age-Reversal Or Anti-Aging
Age-Reversal Or Anti-Aging TELOMIR AGE REVERSAL What do we mean by “Age Reversal” or “Anti-Aging”? It’s not the fountain of youth — it’s the science of telomere elongation While our initial proposed clinical indications for Telomir-1 are osteoarthritis and hemochromatosis, we are also more broadly s
Slide 8: Charles River Laboratories — Rat Study
Charles River Laboratories — Rat Study TELOMIR AGE REVERSAL Effects of Telomir-1 in the Monosodium-lodoacetate (MIA)-induced Osteoarthritis (OA) Joint Pain Model in the Aged Rat + Adult Sprague Dawley rats at 7-9 months old will be used for the study. * Osteoarthritis will be induced by intra-articu
Slide 9: Charles River Laboratories — Rat Study (Continued)
Charles River Laboratories — Rat Study (Continued) TELOMIR AGE REVERSAL Dynamic Weight Bearing System + Bioseb's DWB allows to work with freely + The video feed is analyzed in real-time during the test moving animals in a transparent cage with a thanks to the tracking software allowing a precise ana
Slide 10: Charles River Laboratories — Rat Study (Continued)
Charles River Laboratories — Rat Study (Continued) TELOMIR AGE REVERSAL Terminal Endpoints + Joint synovial fluid will be collected for inflammatory + Whole blood will be collected for Telomer length cytokines measurement assessment. Gross section ofa healthy oi Timeline e ry ry Study Study Data Ini
Slide 11: Argenta - Midwest Veterinary Services - Dog Study
TELOMIR Argenta - Midwest Veterinary Services, Inc. - Dog Study AGE ERUELERT Determining the efficacy of Telomir-1 on Mitigating the Clinical Signs of Osteoarthritis using a Femoral Induction Model in Laboratory Beagle Dogs + Primary objective: Evaluate the efficacy of Telomir-1 for mitigating the p
Slide 12: Argenta - Midwest Veterinary Services - Dog Study (Continued)
Argenta - Midwest Veterinary Services, Inc. - Dog Study (Continued) TELOMIR AGE REVERSAL Determining the efficacy of Telomir-1 on Mitigating the Clinical Signs of Osteoarthritis using a Femoral Induction Model in Laboratory Beagle Dogs + Start of in-life phase Q2 2024 End of Live Phase (necropsy) Q4
Slide 13: Age Group
TELOMIR AGE REVERSAL Age Group Geriatric (n= 5) J Treament \ Phase No(n=1y No(n= 1)" Yes (n= 4) 29 years og Telomir-t (n= 2) Placebo (n = 2) Telomi-t (n= 6) Placebo (n= 2) *One dog in each age group will not be enrolled in the treatment phase. If all the dogs within an age group are eligible for enr
Slide 14: Telomir Preclinical/Clinical Development Program
TELOMIR Telomir Preclinical/Clinical Development Program AGE REVERSAL Q22024 May-December B @ IND - Osteoarthritis (humans) Phase | > Phase II © Telomir Science © Rat Osteoarthritis and © Dog Osteoarthr © Stem Cell Thera ats and Aga Reverse! sumere ry Charles River Laboratories Argenta © Telomere El
Slide 15: The Science of Telomir
The Science of Telomir TELOMIR AGE REVERSAL |. Why Telomeres Matter to Longevity: Stem Cells Repair YOU Il. Early Results Supporting Hypothesis that Telomir-1 Increases Telomere Length and that Telomir-1 May Do So By Increasing Telomerase Kandi Amelon
Slide 16: The Study: Harvesting and Culturing Stem Cells - Heart
The Study: Harvesting and Culturing Stem Cells - Heart TELOMIR AGE REVERSAL Stem Cells & Telomere Regeneration * Stem cells are the matriarchs of the human body—the cells from which all other cells are derived. Another way stem cells are maternal: they come in and repair things + We learned this aft
Slide 17: The Study: Harvesting and Culturing Stem Cells - Stroke
TELOMIR The Study: Harvesting and Culturing Stem Cells - Stroke Rag WEVERSAL Stem Cells & Telomere Regeneration + Stem cells are the matriarchs of the human body—the cells from which all other cells are derived. Another way stem cells are maternal: they come in and repair things + The Problem: each
Slide 18: Elizabeth Blackburn: Nobel Prize on Telomeres
Elizabeth Blackburn: Nobel Prize on Telomeres TELOMIR AGE REVERSAL The Nobel Assembly at Karolinska Institute (Sweden) awarded the Nobel Prize in Physiology or Medicine 2009 jointly to Elizabeth Blackburn, Carol Greider and Jack Szostak for the discovery of how chromosomes are protected by telomeres
Slide 19: Advantages of Elongating Telomeres
TELOMIR Advantages of Elongating Telomeres AGE REVERSAL Stem Cells & Telomere Regeneration + Stress shortens telomeres + People who regularly eat sugar laden and processed food have shorter telomeres + People who regularly do extreme physical activity have shorter telomeres + Astronauts have shorter
Slide 20: Telomere Regulation
Telomere Regulation TELOMIR: AGE REVERSAL The overarching goal of the study was to evaluate evidence that TELOMIR-1 can promote telomere elongation and stability, leading to a slower progression of diseases and self-renewal. We have limited stem cells to repair ourselves due to limits on telomeres a
Slide 21: Advantages of Elongating Telomeres
Advantages of Elongating of Elongating TELOMIR AGE REVERSAL Stem Cells & Telomere Regeneration Imagine if you could repair each organ or tissue with age-related damage and make that tissue young again Young heart Young blood vessels Young brain Young joints Young back discs Young lung Young kidney Y
Slide 22: Early Data on Telomir-1 Elongating Telomeres And its Possible Mechanism of Action
TELOMIR AGE REVERSAL Early Data on Telomir-1 Elongating Telomeres And its Possible Mechanism of Action—Increasing Telomerase Dr. Michael F. Roizen
Slide 23: Experimental Design
Experimental Design Experimental Design for telomere length quantification. Briefly, MRC-5, HUVEC, or MSCs were grown to confluency and plated in a 12-well plate either untreated or treated with the TELOMIR-1 compound. After 48- hours, DNA was extracted and then DNAs were subjected to qPCR via a kit
Slide 24: TELOMIR-1-Mediated Cytotoxicity Assessment
TELOMIR-1-Mediated Cytotoxicity Assessment TELOMIR AGE REVERSAL TELOMIR-1-mediated cytotoxicity was assessed. MRC-5, HUVEC, and MSCs were treated with TELOMIR-1 at 1, 10, 25, 50, 100, 250, 500, and 1000 uM. TELOMIR-1 demonstrates no cytotoxicity at 1-250 uM concentration in MRC- 5 (Figure A) and HUV
Slide 25: High Dose Telomir-1 Induces Cell Apoptosis Instead of Necrosis in MRC-5
High Dose Telomir-1 Induces Cell Apoptosis Instead of Necrosis in MRC-5 TELOMIR AGE REVERSAL MRC-5 was treated with TELOMIR-1 at 500 UM, a known concentration that led to cell loss in MRC-5. The treated cultures were then triple-stained with an anti-active Caspase-3 antibody, dead cell exclusion dye
Slide 26: Telomerase Activity Assessment
ity Assessment TELOMIR AGE REVERSAL Telomerase Acti’ Hypothesis: TELOMIR-1 modulated telomere length via enhancing Telomerase activity. + Previously, we've demonstrated that TELOMIR- did Telomere Length not affect telomerase activity in passage 3 of MRC-S 00. ected cells, which corresponded with the
Slide 27: Telomerase Activity Assessment
Telomerase Activity Assessment TELOMIR AGE REVERSAL Background: MRC-5 Passage 4 (P4) cells were treated with 1, 50, 100, and 500 uM of TELOMIR-1. Cells were then lysed and processed for telomerase activity using qPCR. Telomerase Activity, 24 hr treatment MRCS (P4) Relative Telomerase Activity Result
Slide 28: Conclusions
Conclusions TELOMIR AGE REVERSAL 1. The data confirmed our hypothesis that TELOMIR-1 affects telomere length, promoting its extension in primary cell strains including MRC-5, HUVEC, and MSCs (~40% increase). 2. TELOMIR-1 was observed to cause cell cytotoxicity at a concentration of 500 UM in both MR
Slide 29: Georgetown Group
Georgetown Group TELOMIR AGE REVERSAL Telomir Pharmaceuticals has formed a Georgetown Group --- this Group of 14 from fields of Medicine, Medical Ethics, Public Relations, Law and Economics has begun work to address obvious issues in Telomir's development: 1. Formation of an Ethical Advisory Panel:
Slide 30: Questions and Answers
QUESTIONS AND ANSWERS TELOMIR AGE REVERSAL Questions from the Audience Kandi Amelon
Slide 31: 2024 | Telomir
2024 | TELOMIR
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