Perspective Therapeutics, Inc. · AMEX:CATX
Perspective Therapeutics — Investor Presentation (March 2025)
62 slides from Perspective Therapeutics's investor presentation, Mar 26, 2025
Slide 1: Corporate Presentation
PERSPECTIVE THERAPEUTICS Corporate Presentation NYSE AMERICAN: CATX
Slide 2: Legal Disclaimers
Legal Disclaimers This presentation contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not statements of historical fact are forward-looking statements. Words such as “may,” “will,” “s
Slide 3: Developing the Next Generation of Targeted Therapies
Developing the Next Generation of Targeted Therapies
Slide 4: Higher Potency Payloads with Cancer-Specific Targeting
Higher Potency Payloads with Cancer-Specific Targeting
Slide 5: Broad Proprietary Pipeline
Broad Proprietary Pipeline Three lead programs in clinic with multiple programs in preclinical development Program . (lareet) Target Disease VMT01/02 Melanoma (cir) (MC1R Imaging & Therapy) Neuroendocrine Tumors VMT-a-NET (ssTR2) Other SSTR2 Expressing Tumors PSV359 " " ait Prostate XX (PSMA) {PaMe
Slide 6: Radiopharmaceutical Therapy Poised to Revolutionize Oncology Treatment
Radiopharmaceutical Therapy Poised to Revolutionize Oncology Treatment Perspective’s pipeline and platform has the potential to significantly expand the breadth of tumors addressed by RPT
Slide 7: The Theranostics Advantage
The Theranostics Advantage Imaging in animal models and human patients facilitates peptide optimization and derisking imaging studies Generate Novel A Development Optimize “ Cee Targeting ws s Gra caimit FIH Imaging Candidate IND Moieties In Vivo Nomination Compound Compound Compound 3-301 3-421 59+
Slide 8: Perspective's Innovative Platform
Perspective’s Innovative Platform
Slide 9: Perspective's Radiopharmaceutical Platform Optimized for a Broader Therapeutic Window
Perspective’s Radiopharmaceutical Platform Optimized for a Broader Therapeutic Window
Slide 10: Perspective's Proprietary Chelator Has Been Optimized for Lead-Based RPTs
Perspective’s Proprietary Chelator Has Been Optimized for Lead-Based RPTs
Slide 11: Lead-212: The Optimal Therapeutic Isotope
Lead-212 (2!2Pb): The Optimal Therapeutic Isotope 212Pb provides numerous advantages over beta particle radiotherapies and other alpha emitters Rationale favoring Lead (??2Pb) ae i : Lutetium (?77Lu) Actinium (225Ac) Lead (212Pb) 6 radiation a radiation a radiation a. ' 7 + § Potency Cr) Alpha parti
Slide 12: Pb-based Theranostics Enable Both Diagnosis and Targeted Treatment of Cancer
Platform Pb-based Theranostics Enable Both Diagnosis and Targeted Treatment of Cancer Identical distribution of 2°2Pb and 2!Pb for imaging and treatment, respectively Imaging Cancer Cell 203Pbh Patient selection Dosimetry: T,,, = 52h Ww i 203Pb can be used uae Linker to establish ??Pb pharmacokineti
Slide 13: Proposed Mechanism of Action for 212Pb
Proposed Mechanism of Action for 212Pb
Slide 14: Rationale for Synergy with Immune Checkpoint Inhibitors
Rationale for Synergy with Immune Checkpoint Inhibitors
Slide 15: Pre-Targeting Platform
Platform Pre-Targeting Platform Potential to Significantly Expand Therapeutic Window by Utilizing Different Kinetics of Proteins and Small Molecules! ‘-) Administer cold modified monoclonal ii Peg antibody or targeting protein r 3) Administer radiolabeled ligand Ligand binds only to modified mAb Aft
Slide 16: Supply Chain and Manufacturing Infrastructure
Supply Chain and Manufacturing Infrastructure
Slide 17: On-Demand Order Fulfillment at Regional Sites to Deliver Finished Products
On-Demand Order Fulfillment at Regional Sites to Deliver Finished Products
Slide 18: Supply Chain & Manufacturing
Supply Chain & Manufacturing Regional Manufacturing Allows Commercialization of 2!2Pb-labeled Finished Products The “network effect” designed to ensure reliable commercial supply for ready-to-inject therapeutics Sites Today 2027+ 2029 Population Radius “11 hrs Coralville, IA Clinical Supply Somerset
Slide 19: Neuroendocrine Tumors: VMT-α-NET
Neuroendocrine Tumors: VMT-⍺-NET
Slide 20: Clinical Pipeline: Neuroendocrine Tumors VMT-α-NET
Clinical Pipeline Neuroendocrine Tumors: VMT-a-NET Targeting the somatostatin receptor to treat neuroendocrine and other cancers Neuroendocrine cells are specialized cells that secrete hormones and other bioactive substances Disease Most neuroendocrine tumors highly express somatostatin receptor typ
Slide 21: Platform Demonstrates Superior Therapeutic Window: VMT-α-NET
Perspective’s Platform Demonstrates Superior Therapeutic Window: VMT-a-NET In-house discovery capabilities deliver differentiated molecules Key Takeaways vs Generic Compounds Shows Significant Improvement vs Standard of Care in Preclinical Models Preclinical Studies: Decreased Off-Target Toxicity, S
Slide 22: 203Pb SPECT Imaging Reveals Favorable VMT-α-NET Properties
203Pb SPECT Imaging Reveals Favorable VMT-a-NET Properties” Rapid Tumor Targeting High Tumor and Renal Clearance Retention * Tumors visible within 1 hour indicates rapid binding to SSTR2 target High intensity above background Xd ; . implies excellent therapeutic : window — = . bd Unbound drug in bla
Slide 23: Trial Design: [212Pb]VMT-α-NET Phase 1/2a
Trial Design: [212Pb]VMT-⍺-NET Phase 1/2a For Neuroendocrine Tumors
Slide 24: Anti-Tumor Activity
Anti-Tumor Activity Preliminary response assessment by RECIST v1.1 showed 3 responses in 7 patients from Cohort 2 Percent change in sum of diameters from baseline —@— (°Pb]VMT-o-NET 2.5 mCi (92.5 MBq) —@®— [22Pb]VMT-a-NET 5.0 mCi (185 MBq) 20% 10% 7% 2.6% sD sD sD uPR uPR PR ox | 5.2% | — PD sD sD -
Slide 25: Signal of Sustained Anti-Tumor Activity
Signal of Sustained Anti-Tumor Activity
Slide 26: [212Pb]VMT-α-NET Was Well Tolerated
[212Pb]VMT-α-NET Was Well Tolerated
Slide 27: No Decline in Renal Function Observed
No Decline in Renal Function Observed
Slide 28: Conclusion & Next Steps
Conclusion & Next Steps [?Pb]VMT-a-NET was well tolerated, supporting rationale for potential dose escalation [222Pb] VMT-a-NET was well-tolerated? * No DLTs * No grade 4, grade 5 AEs or SAEs * No decline in renal function * Hematologic AEs were low in number and low grade * No treatment discontinua
Slide 29: Patient with PR after [212Pb]VMT-α-NET
Patient with PR after [212Pb]VMT-α-NET
Slide 30: Melanoma Program: VMT01/02
Melanoma Program: VMT01/02 Using the melanocortin receptor (MC1R) to target melanoma for imaging and therapy
Slide 31: Melanoma Program: VMT01/02
Melanoma Program: VMT01/02 Using the melanocortin receptor (MC1R) to target melanoma for imaging and therapy Treatment may include surgery, radiation, chemotherapy and immunotherapy Disease * Advanced stages of disease occurs throughout the body requiring aggressive systemic treatment Overview * Hig
Slide 32: Combination [212Pb]VMT01 with Immune Checkpoint Inhibitors
Combination [2?2Pb]VMT01 with Immune Checkpoint Inhibitors Lower radiation dose shows superior efficacy in preclinical combination with ICs Monotherapy [212Pb]VMTO1 Combination Therapy [212Pb]VMTO1 + ICIs 600 @ Control (n=8) 0003 @ /Cls (n=7) > © 19 MBq (n=6) = = "g 80018 19 MBq + ICls (n=7) AS © 3.
Slide 33: [212Pb]VMT01 in Combination: Synergistic Responses in Preclinical Studies
[222Pb]VMTO1 in Combination: Synergistic Responses in Preclinical Studies Single dose of VMTO01 in combination significantly arrested melanoma tumor growth and extended survival immunodeficient human melanoma xenograft model — BRAF-positive* Single dose VMTO1 + BRAFi immunocompetent mouse B16:F10 me
Slide 34: [68Ga]VMT02 PET Imaging in Patient with MC1R Positive Metastatic Melanoma
[®Ga]VMTO2 PET Imaging in Patient with MC1R Positive Metastatic Melanoma Diagnostic peptide demonstrates similar uptake to FDG in tumors 18F-FDG (Standard of Care) [®Ga]vMTo02 Patient information * Male, Asian, 33 years old * [§8Ga]VMTO2: 7 mCi injection, 45 min post-injection imaging 34 | Giinical
Slide 35: Trial Design: [212Pb]VMT01 Phase 1/2a For Metastatic Melanoma
Trial Design: [212Pb]VMT01 Phase 1/2a For Metastatic Melanoma
Slide 36: Preliminary Anti-Tumor Activity of [212Pb]VMT01 Observed at Lower Dose
Preliminary Anti-Tumor Activity of [212Pb] VMTO1 Observed at Lower Dose Per preclinical studies, immunostimulatory effect leading to immune-mediated stable disease hypothesized at lower doses Observed PFS for heavily pre- treated ee [22Pb]VMTO1 Cohort 1: 3.0 mCi (111MBq) ‘i [222Pb]VMTO1 Cohort 2: 5.
Slide 37: Treatment Emergent Adverse Events
Treatment Emergent Adverse Events (occurring in ≥ 2 patients and/or Grade ≥ 2)
Slide 38: Conclusion & Next Steps
Conclusion & Next Steps Activity seen in 3 mCi dose cohort supports dose reduction and nivolumab combination [222Pb]VMT01 was well-tolerated at doses studied? * At3 mCi and 5 mCi activity levels, [212Pb]VMTO1 was well-tolerated and no DLTs were observed * Dosimetry demonstrates high kidney estimates
Slide 39: Pan-Cancer Target: PSV359
39 Pan-Cancer Target: PSV359 Preclinical Activity and First in Human Images of Novel Peptide Targeting Fibroblast Activation Protein-alpha (FAP-a) (a) PERSPECTIVE THERAPEUTICS
Slide 40: Pan-Cancer Program: PSV359
Pan-Cancer Program: PSV359 Novel peptide targeting fibroblast activation protein-alpha (FAP-a) * FAP-a is expressed in the tumor stroma of many epithelial cancers and on the cell surface of other tumor types Disease * FAP Expression on Tumor Stroma: Non-Small Cell Lung Cancer, Pancreatic, Hepatocell
Slide 41: Pan-Cancer Program: PSV359
Pan-Cancer Program: PSV359 Fibroblast activation protein alpha (“FAP”) is a pan-cancer target In some tumor types, FAP In other cancers, FAP is 4% a is expressed on the cancer primarily expressed on cells as well as on stroma tumor stroma cells and not 3 eh > cells on the cancer cells ¢ . oe . - ~~
Slide 42: Novel Compound Development
Novel Compound Deve In-house peptide synthesis and in vivo capability allows rapid iteration and optimization of novel compounds F - . - Phage display scr 5 | Compound 3-30 [ Compound 3-42 | Compoun AVAV AN & BP, BN dgoorrenen S * Phage display followed by affinity maturation * Bioconjugate chemistr
Slide 43: PSV359 is Active Against FAP-α Expression on Tumor and on Stroma
PSV359 is Active Against FAP-α Expression on Tumor and on Stroma
Slide 44: [68Ga]PSV377 PET Imaging in Patient with Metastatic Colorectal Cancer
[®8Ga]PSV377 PET Imaging in Patient with Metastatic Colorectal Cancer Diagnostic FAP-targeted peptide demonstrates excellent uptake in tumors [?8F]FDG MIP (Standard of Care) [°Ga]PSV377' MIP Patient information: * Male, Asian, 34 years old + [8Ga]PSV377: 3.2 mCi injection, 30 min post-injection imag
Slide 45: FIH Imaging of [203Pb]PSV359 in Different Types of Cancers
FIH Imaging of [2°2Pb]PSV359 in Different Types of Cancers Chondroblastic Osteosarcoma [2°2Pb]PSV359 [2°Pb]PSV359 SPECT/CT ‘> , * =% .* é ° 4hr 18 hr 1 hour 4 hour 18 hour Lesion in head of left humerus as | ; P™) PERSPECTIVE THERAPEUTICS
Slide 46: Conclusion & Next Steps
Conclusion & Next Steps Preclinical data and first-in-human imaging data supportive of FIH therapeutic study in 2025 Strong scientific rationale * FAP-a is a pan-cancer target that is abundantly expressed in certain cancer cells as well as cancer-associated fibroblasts in tumor lesions and involved
Slide 47: General Corporate Information
General Corporate Information
Slide 48: Deeply Experienced Management Team in Radiopharmaceuticals and Oncology Drug Development
Deeply Experienced Management Team in Radiopharmaceuticals and Oncology Drug Development 20+ years of expertise in biot jology companies; public and private companies; oncology and nuclear pharmacy Thijs Spoor Chief Executive Officer - cotynia Srsiswio TEE verify.» Vewront ror Aa om BD 20+ years of
Slide 49: Strong Intellectual Property Portfolio
Strong Intellectual Property Portfolio Perspectiv: wned/Exclusively-licensed IP 8 Issued Patents (Expiry in 2037 and 2040, with potential PTE) Composition of matter for melanoma targeted radiopharmaceutical compounds; methods of combination therapies; methods of creating radiopharmaceutical compound
Slide 50: Strong Financial Position
Strong Financial Position Funding into late 2026 Cash, cash equivalents and short-term investments as of December 31, 2024 ~$227 million Share count as of December 31, 2024 70.7 million Outstanding common stock warrants & options as of December 31, 2024 7.8 million Outstanding pre-funded warrants as
Slide 51: Slide 51
Slide 52: Abbreviations
Abbreviations AE: adverse event APC: antigen-presenting cell ASCO-GI: ASCO Gastrointestinal Cancers Symposium CTLA-4: human cytotoxic T-lymphocyte antigen 4 DAMPs: damage-associated molecular patterns DLT: dose limiting toxicities DOR: duration of response dsDNA: double-stranded DNA EANM: European A
Slide 53: APPENDIX
APPENDIX
Slide 54: Radiopharmaceutical Therapies Have Potential to Disrupt Cancer Treatment
Radiopharmaceutical Therapies Have Potential to Disrupt Cancer Treatment First patient treated with Perspective’s VMT-a-NET Tumor Before Treatment Tumor After 3 Doses Transverse (horizontal) plane: PET/CT (top panels) & CT (bottom panels) (S.ACTH)*— 790 pg/ml S.ACTH — 96 pg/ml 54 ‘ay PERSPECTIVE THE
Slide 55: NETs Trials
NETs Trials Lu-DOTA’ Lu-EDOTREOTIDE ‘Pb-DC (Ph 3 dose is fixed 10.2 MBq) ©28.4ys8.Smonths? | NE(95% I-12 months, NE) 13% (195/125) vs. 4% (0%/4%) 29.496 confirmed 41.2% (6%/35%) w/ unconfirmed +USPI; “DOI: 10.1056/NEJMoa1607427; "NANETS 2021; “DOI: 10.1016/S0140-6736124)00701-3; “ENETS 2025: * 7aSCO
Slide 56: Refractory Metastatic Melanoma Trials
Refractory Metastatic Melanoma Trials
Slide 57: 212Pb Isotope Decay Chain and Importance of the Pb-Specific Chelator
212Pb Isotope Decay Chain and Importance of the Pb-Specific Chelator Thorium Where the drug goes = where the 1sy alpha particle is deposited @) OH 2 Bj Bismuth 61m * Perspective’s proprietary chelator retains 98% of 2128) after transition in drug formulation? * Generic chelators leak the 2?2Bi alpha
Slide 58: 225Ac Isotope Decay Chain and Potential for Off-Target Toxicity
225\c Isotope Decay Chain and Potential for Off-Target Toxicity Isotope Supply Production Therapy Bismuth 46m | A¥P1KO] 32310 1-440 404 [eHUDIOg Alpha-particle emission OH imparts sufficient “recoil” fe) energy to break chemical aN s~¢ bonds N O o = Target Organs @ Liver @) Kidneys @) PY) PERSPECTIV
Slide 59: 212Pb Hits Tumors Hard and Fast and Disappears
212Pb Hits Tumors Hard and Fast and Disappears 212Pb is a “high dose rate” alpha emitter with a short half life — energy is deposited rapidly to tumor and then gone Comparative al Particle Decay Over Time! 59 Comparative alpha decays Delivering alphas faster while drug and isotope tumor retention is
Slide 60: Isotope: Decay chain — Product implications
Isotope: Decay chain — Product implications Post final radiolabeling and purification, alpha and beta emitting daughters of 2°Ac build up fast Ac-225 Decay and Daughter Ingrow’ Dose Vial “Free” Radiometals: @Ac225 MFr-221 MAt-217 MBi-213 MTI-209 mPo-213 4x more unlabeled daughter activity in about 4
Slide 61: Isotope: Decay chain — Biological Implications
Isotope: Decay chain — Biological Implications Isotope selection drives potential for off target toxicities 25Ac has potential for off target toxicity Recoil breaks 22Pb decay is limited chemical bonds to tumor Decay products circulate and continue to emit radition CP) PersPective 61 THERAPEUTICS
Slide 62: Perspective's Pre-Targeting Platform
Perspective’s Pre-Targeting Platform
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