Slide 1: A Walk Around the Intuvo
A Walk Around the Intuvo Simon Jones GC Application Scientist February 13, 2019 1 February 13, 2019
Slide 2: Innovating a New Path to GC Productivity
Innovating a New Path to GC Productivity A whole new way to GC • Easier • Faster • Smaller • Smarter • Greener 2
Slide 3: Innovating a New Path to GC Productivity: Direct heating
Innovating a New Path to GC Productivity A whole new way to GC Direct heating 3
Slide 4: Innovating a New Path to GC Productivity: No-trim column
Innovating a New Path to GC Productivity A whole new way to GC No-trim column Direct heating 4
Slide 5: Innovating a New Path to GC Productivity: Click-and-run
Innovating a New Path to GC Productivity A whole new way to GC Ferrule-free click-and-run connections No-trim column Direct heating 5
Slide 6: Innovating a New Path to GC Productivity: Guard Chip
Innovating a New Path to GC Productivity A whole new way to GC Disposable Intuvo Guard Chip Ferrule-free click-and-run connections No-trim column Direct heating 6
Slide 7: Innovating a New Path to GC Productivity: Modular Flow Chips
Innovating a New Path to GC Productivity Modular A whole new way to GC Intuvo Flow Chips Disposable Intuvo Guard Chip Ferrule-free click-and-run connections No-trim column Direct heating 7
Slide 8: A New Portfolio of GC Consumables
A New Portfolio of GC Consumables UI inlet liners Guard Chip Smart keys Flow Chips No-trim column Tools and accessories
Slide 9: Intuvo Smart Keys
Intuvo Smart Keys Self aware • Flow Chips and columns • Smart: informs how Intuvo is configured • Easy: sets method context and parameter defaults – no complex calculators needed 9
Slide 10: Flexible Compatible Design
Flexible Compatible Design Configurable to many applications • SSL, MMI, GSV, LSV inlets • FID, TCD, ECD, NPD, FPD, NCD, SCD detectors • SQ and TQ mass spectrometers • Headspace, thermal desorption, purge and trap samplers • 16-, 50-, 150-position autoinjectors and trays • Software: Agilent OpenLab
Slide 11: Comparing the Agilent 7890 GC with the Intuvo 9000 GC
Comparing the Agilent 7890 GC with the Intuvo 9000 GC 7890 Intuvo Footprint (H × W × D) in 19.2 × 22.9 × 20.2 20 × 10.7 × 27.2 Inches Power Consumption 2,250 VA standard (2,950 VA /220) 1,296 VA standard (1,548 VA / 220) Oven Ramp Rate Temperature 120 V Fast Oven Fast oven Range (°C) Oven with Pillo
Slide 12: Smaller Footprint
Smaller Footprint 10.7” 22.9” 12
Slide 13: New Heated Zones
New Heated Zones Guard Chip Bus 13
Slide 14: Intuvo with MSD, FID, and Postcolumn Backflush
Intuvo with MSD, FID, and Postcolumn Backflush Mini-Bus 14
Slide 15: What 'Can' it Do?
What ‘Can’ it Do? One inlet (SSL or MMI) Two detectors can split 1:1 between detectors – including MSD Column limitation of 60 m total, max ID of 0.32 mm Midcolumn backflush Postcolumn backflush 15
Slide 16: Innovating the GC Flowpath
Innovating the GC Flowpath Conventional flowpath Inlet Gold seal Nuts and ferrules Classic capillary column To detector 16
Slide 17: Innovating the GC Flowpath
Innovating the GC Flowpath Conventional Intuvo flowpath flowpath Inlet Inlet Guard Chip Gold seal Nuts and ferrules Classic capillary column To detector 17
Slide 18: Innovating the GC Flowpath
Innovating the GC Flowpath Conventional Intuvo flowpath flowpath Click-and-run Inlet Inlet direct connections Guard Chip Gold seal Flow Chip Nuts and ferrules To detector Classic capillary Intuvo planar column column To detector 18
Slide 19: Modular Intuvo Flow Chips
Modular Intuvo Flow Chips High-purity inert silica flowpath Thermally conductive proprietary alloy Intuvo Ultra Inert treatment • Inert • Modular, configurable • Click-and-run connections Intuvo Flow Chip cross section High-purity Carrier silica channel gas 19
Slide 20: Guard/Jumper Chips
Guard/Jumper Chips Roughly 0.75 m × 0.53 mm ID 20
Slide 21: Click-and-Run Direct Connections
Click-and-Run Direct Connections Eliminating connection uncertainty • No more ferrules • Direct face seal connections • Audible and tactile click lets you know connection is made • Easier to train • Less unplanned downtime • Fewer batch reruns and precious samples lost 22
Slide 22: Intuvo Flow Chips – Installation Distance Always Perfect
Intuvo Flow Chips – Installation Distance Always Perfect
Slide 23: No more measuring, overtightening, trimming
No more: - measuring - overtightening - trimming
Slide 24: Intuvo Inert Flowpath
Intuvo Inert Flowpath Optimized for active compounds Pyroclostrobin 5 ppb injection of pesticide mix Chrysene-d12 TQ MRM transitions Perylene-d12 Agilent 7000 triple quadrupole GC/MS Phosalone EPN Coumaphos 25
Slide 25: Intuvo Graphical User Interface
Intuvo Graphical User Interface • System status 26
Slide 26: Intuvo Graphical User Interface
Intuvo Graphical User Interface • System status • Real time pA chromatograms 3000 2500 2000 1500 1000 500 0 0.6 0.8 1.0 1.2 1.4 1.6 1.8 min. 27
Slide 27: Intuvo Graphical User Interface
Intuvo Graphical User Interface • System status • Real time Find Inlet Parts chromatograms Replace Inlet Liner Inlet Liner Part Number 8001- • Finding parts fast 0101 28
Slide 28: Intuvo Graphical User Interface
Intuvo Graphical User Interface • System status • Real time chromatograms • Finding parts fast • Step-by-step user maintenance and troubleshooting 29
Slide 29: Autonomous Leak Checking
Autonomous Leak Checking Avoiding unplanned downtime Microfluidic-enabled sixth generation EPC modules allow hands-free leak checking to confirm and document leak-free operation autonomously. 30
Slide 30: Intuvo Graphical User Interface: Interactive maintenance
Intuvo Graphical User Interface Interactive maintenance Replace liner Remove lock nut and septum Step 1: Remove lock nut 31
Slide 31: Maintenance?!
Maintenance?! You lose the screen as soon as you open the door to do the maintenance! 32
Slide 32: Remote Access to Intuvo Screen
Remote Access to Intuvo Screen
Slide 33: Access the Onscreen Tools Remotely
Access the Onscreen Tools Remotely
Slide 34: Counters Give you Quick System Information
Counters Give you Quick System Information 35
Slide 35: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Tools Collect tools needed to perform the maintenenance Intuvo torque driver Tweezers “Agilent
Slide 36: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Preparing for maintenance, cooling down the heated zones... A\cauti Detector 4 Tail Detector 1 : These zones are hot and are not being cooled: Waiting for these zon
Slide 37: Column Maintenance
Column Maintenance Description Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Dpen the column oven Open the GC front door. Remove the bus door. Lower the oven door. “Agilent
Slide 38: Column Maintenance
Column Maintenance Descript Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Remove compression bolts Remove compression bolts and store for later use. “Agilent
Slide 39: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Dpen column clamps and remove column Open clamps. Unplug column Smart Key. Remove column.
Slide 40: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Replace gasket Remove old gasket using tweezers. Install new gasket.
Slide 41: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Place the column Place the column on the bottom clamps. Tilt the column up so the click and run connectors mate into the bus fitting. Loosely install the compressio
Slide 42: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Check column placement and tighten compression bolts The click and run connectors should sit flat against the gaske Tighten the compression bolts until you hear one
Slide 43: Column Maintenance
Column Maintenance Column 1 Maintenance Description - Self guided procedures for performing column maintenance Replace Column Procedure Secure column Close the column clamps. Install the bus door.
Slide 44: Column Maintenance – Automatic Leak Checks!
Column Maintenance – Automatic Leak Checks!
Slide 45: Column Maintenance – Automatic Leak Checks!
Column Maintenance – Automatic Leak Checks!
Slide 46: Column Installation 'Gotchas'!
Column Installation It is much easier to install the column, but there are still some ‘Gotchas’! 47
Slide 47: Tips to Ensure a Good Column Installation
Tips to Ensure a Good Column Installation 1. Finger tighten until only one thread on each of the two nuts is showing. If more than one thread is showing, wiggle or reposition the column into place to further finger- tighten the nuts to one thread.
Slide 48: Tips to Ensure a Good Column Installation
Tips to Ensure a Good Column Installation 2. Check that the small integrated column nuts on the column are in form- fitted place on the heater in the instrument. 3. Click and run!
Slide 49: Intuvo Guard Chip and No-Trim Columns
Intuvo Guard Chip and No-Trim Columns No retention time shifts after maintenance Conventional Column Intuvo Column Shifts beyond Maintaining retention time retention times window 0.5 min 0.5 min Pesticide mix injected before and Pesticide mix injected before and after 300 mm column trim after Guard
Slide 50: Guard Chip Versus Column Trimming
Guard Chip Versus Column Trimming 7890 x10 6 3.6 1 3.4 5 1 3.2 6 3 1 2.8 3 2.6 1 2.4 0 2.2 1 2 1 1 1 8 1.8 2 7 1.6 4 1.4 1.2 1 0.8 1 0.6 1 0.4 0.2 0 27 27.5 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 33 33.5 34 34.5 35 35.5 36 36.5 37 37.5 Counts vs. Acquisition Time (min) Intuvo 1 1 x10 4 5 5 6 4.8 4.
Slide 51: Seamless Method Migration to Intuvo
Seamless Method Migration to Intuvo No business disruption 83 SVOC by US EPA 8270 x10 1 + TIC Scan 12 CAL 10 (20000 ppb) - Apr 30.d 3.7 3.6 3.5 3.4 3.3 Intuvo 3.2 3.1 3 2.9 2.8 2.7 2.6 2.5 2.4 2.3 2.2 2.1 2 1.9 1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 4 4.5 5 5.5 6 6.5
Slide 52: How Does it Line Up?
How Does it Line Up? 7890 GC PAHs 1 2 3 4 5 6 7 8 13 15, 16, 17 12 9 10 18 14 21 11 20 19 22 23 24 25 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 Acquisition T
Slide 53: Fast Direct Heating and Cooling
Fast Direct Heating and Cooling Every single minute counts • Fast, efficient heating • Ballistic cooling • Smaller footprint “We are the police – we need answers fast. Even a 1 minute faster cool-down would be valuable…” 54
Slide 54: Ultra Fast GC
Ultra Fast GC It’s all about how well you do GC, fast Recovery C5 0.9 • Excellent retention time and C6 0.9 C7 1.0 pA C12 area count reproducibility C8 1.0 3000 • No concern for cold spots C9 1.0 C10 1.0 C11 1.0 C12 1.0 2500 C14 1.0 C14 C16 C15 1.0 C16 1.0 2000 C17 1.0 C10 C5 C18 1.0 C11 1500 C7 C20
Slide 55: Efficient, Even, Direct Heating
Efficient, Even, Direct Heating Even high molecular PAHs 0.098 ug/mL 9000/5977A (scan) weight compounds such 120 Benzo[b]fluouranthene Benzo[k]fluoranthene as Benzo(ghi)perylene Perylene-d12 (ISTD) 100 Dibenz[a,h]anthracene (molecular weight 276 80 Benzo[a]pyrene Indeno[1,2,3-cd]pyrene Benzo[ghi]per
Slide 56: Optimizing Lab Space
Optimizing Lab Space Supporting lean laboratory thinking Less than half: • Power consumption • Heat output into laboratory • Laboratory bench footprint • Lower operating costs • Higher efficiency • Greener 57
Slide 57: Accessing the Power of Innovation
Accessing the Power of Innovation Transforming the user experience New mobilized generation • Expectations of remote mobile connection • Technology accessed through interactive graphic SW and apps Make technology accessible • Interface meeting today’s expectations 58
Slide 58: Internet of Things
Internet of Things A full suite of customer support • Intuvo serves up a web homepage • User help for maintenance, troubleshooting, and diagnostics • Accessible through any approved PC or mobile device securely on internal network 59
Slide 59: Go Mobile
Keep Connected Tablet or phone connectivity Check instrument and batch status remotely Confirm laboratory operations while out of the laboratory Go Mobile Connect to any instrument with a single mobile device 60
Slide 60: A Gateway of Information at Your Fingertips
A Gateway of Information at Your Fingertips Whenever and wherever you are • Online resources • Agilent University • YouTube • Agilent.com • Agilent GC community 61
Slide 61: Agilent CrossLab Services for Intuvo
Agilent CrossLab Services for Intuvo A streamlined service experience Intuvo 9000 GC Health Report Installation and familiarization Compliance services Education 62
Slide 62: An Ideal Partner for Mass Spectrometry
An Ideal Partner for Mass Spectrometry • Guard Chip protection of column and MS ion source • Retention time stability after changing Guard Chip • Easy and reliable backflush • Leak-free click-and-run connections • Fast direct heating and cooling 63
Slide 63: Intuvo 9000 GC Videos
Intuvo 9000 GC Videos The Agilent Intuvo 9000 GC System – Environmental Science Corporation (ESC) Discover higher GC productivity with the Agilent Intuvo 9000 GC system. Playing Time: 4:00 The Agilent Intuvo 9000 GC System Story Learn more about the Agilent Intuvo 9000 GC System Playing Time: 2:21 T
Slide 64: Questions
Questions 65 August 2016 AGILENT CONFIDENTIAL
Slide 65: Contact Agilent Chemistries and Supplies Technical Support
Contact Agilent Chemistries and Supplies Technical Support 1-800-227-9770 Option 3, Option 3: • Option 1 for GC/GCMS Columns and Supplies • Option 2 for LC/LCMS Columns and Supplies • Option 3 for Sample Preparation, Filtration, and QuEChERS • Option 4 for Spectroscopy Supplies • gc-column-support@a