Generation Bio — Technical Presentation (October 2023)

4 slides from Generation Bio's technical presentation, Oct 26, 2023

Slide 1: Figure 1: mRNA expression with T cell ctLNP in humanized mouse model
Figure 1: mRNA expression with T cell ctLNP in humanized mouse model
Slide 2: Figure 2: Dose response with T cell ctLNP in humanized mouse model
Figure 2: Dose response with T cell ctLNP in humanized mouse model In a separate NHP study, the company confirmed the properties of its stealth LNP, including long circulating half-life and very low off-target delivery to liver and spleen, as shown in Figures 3a and 3b.
Slide 3: NHP mRNA biodistribution at 6hr, % dose administered
% Dose Administered 100: 0.01 Blood NHP mRNA BioD at 6hr 40% in circulation 0.001% __ 0.003% Liver Spleen Kidney Heart
Slide 4: Figure 3a: Half-life of stealth LNP; Figure 3b: Biodistribution in NHPs
Figure 3a: Half-life of stealth LNP in NHPs and mice Figure 3b: Biodistribution of stealth LNP in NHPs “ The mRNA expression data indicate the power of ctLNPs to de-target the liver and spleen and reach specific extrahepatic cell types by using a targeting ligand,” said Phi