Bayer Ag · XETR:BAYN

Bayer — 23rd European Society of Retina Specialists (EURETINA) Congress 2023

10 slides from Bayer's conference presentation, October 2023

  1. Slide 1: Intravitreal Aflibercept 8 mg for Diabetic Macular Edema: Week 48 Efficacy Outcomes

    Intravitreal Aflibercept 8 mg for Diabetic Macular Edema: Week 48 Efficacy Outcomes by Baseline Demographics in the Phase 2/3 PHOTON Trial Jean-Francois Korobelnik,1,2 on behalf of the PHOTON study investigators 1CHU Bordeaux, Service d’Ophtalmologie, Bordeaux, France 2University of Bordeaux, INSERM

  2. Slide 2: Disclosures

    Disclosures DME • Jean-Francois Korobelnik receives consultant fees for AbbVie, Apellis, Bayer, Janssen, Nano Retina, Roche, Théa Pharmaceuticals, and Carl Zeiss Meditec AG; and is a member of a data safety monitoring board or advisory board for Alexion, Novo Nordisk, and Oxular • This study was spo

  3. Slide 3: PHOTON: Study Design and Dosing Schedule

    PHOTON: Study Design and Dosing Schedule DME

  4. Slide 4: Baseline Demographics

    Baseline Demographics N (FAS/SAF) 167 328 163 658 Age, years 63.0 (9.8) 62.1 (11.1) 61.9 (9.5) 62.3 (10.4) Female, % 44.9% 36.0% 39.3% 39.1% Race, % White 67.1% 70.4% 78.5% 71.6% Black or African American 10.8% 10.7% 5.5% 9.4% Asian 18.0% 14.6% 14.1% 15.3% Other 24% 3.0% 0.6% 24% Not reported 1.8% 1

  5. Slide 5: BCVA Change from Baseline Through Week 48

    Mean Change in BCVA Through Week 48 DME BCVA Change from Baselinea ETDRS Letters

  6. Slide 6: Mean Change in BCVA at Week 48 by Age

    Mean Change in BCVA at Week 48 by Agea DME

  7. Slide 7: Mean Change in BCVA at Week 48 by Sex

    Mean Change in BCVA at Week 48 by Sex DME

  8. Slide 8: Mean Change in BCVA at Week 48 by Race

    Mean Change in BCVA at Week 48 by Racea DME

  9. Slide 9: Mean Change in BCVA at Week 48 by Ethnicity

    Mean Change in BCVA at Week 48 by Ethnicity DME

  10. Slide 10: Conclusions

    Conclusions Mean Change in BCVA at Week 48 by Age? Mean Change in BCVA at Week 48 by Ethnicity Hispanic or Latino Not Hi Lat <55 years 255-<65 years 265-<75 years pa ——=—V—vrve f 10 298 aqi2 aqie 298 8q12 eqs 28 Bqt2aqté 2q8 aqi2 eqs 2q8 eqi2 (n=28)—(n=40)——(n=31) (n=ti9) —(n=234)——(n=115) (928) (n=

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