Resonance Health Ltd · ASX:RHT
Resonance Health — Investor Presentation (March 2016)
19 slides from Resonance Health's investor presentation, March 2016
Slide 1: FerriScan: A clinician's guide to managing transfusional iron overload
FerriScan® provides an accurate assessment of body iron stores A clinician’s guide to managing transfusional iron overload with FerriScan®
Slide 2: Transfusional iron overload
Transfusional iron overload • Patients receiving multiple blood transfusions are at risk of iron overload • One unit of red cells delivers approx 250 mg of iron to the body • The human body has no natural mechanism for excreting iron • Iron chelation therapy is necessary to prevent iron-related tiss
Slide 3: Why is it important to control total body iron stores?
Why is it important to control total body iron stores? • Free iron (labile iron) causes tissue damage • Tissue iron deposits are a source of free iron • The liver is the primary site of iron storage • If liver iron storage capacity is exceeded, iron is deposited in other tissues of the body includin
Slide 4: Goals of iron chelation therapy
Goals of iron chelation therapy • To prevent free iron circulating in the body • To prevent total body iron stores exceeding limit of total iron binding capacity An accurate assessment of body iron stores is required to achieve these goals
Slide 5: Why is measurement of liver iron concentration (LIC) important?
Why is measurement of liver iron concentration (LIC) important? • A patient’s LIC value is the best measure of total body iron stores • A patient’s LIC value enables better informed decisions on when to [1] – Initiate chelation therapy – Increase or decrease chelation dose – Change mode of chelator
Slide 6: LIC is a reliable measure of total body iron stores
LIC is a reliable measure of total body iron stores There is a very strong correlation between LIC and total body iron stores in thalassaemia major patients Angelucci et al. N Eng J Med 2000; 343: 327-31
Slide 7: Relationship between liver and heart iron concentrations
Relationship between liver and heart iron concentrations The liver is considered the early warning system against cardiac complication which may result from myocardial iron loading. • 14 adult non-thalassaemic patients with transfusional iron overload and uncomplicated chelation history • Iron loadi
Slide 8: Survival directly related to effective chelation therapy
Survival directly related to effective chelation therapy • Group 1: high pretreatment iron load and ineffective chelation • Group 2: high pretreatment iron load and effective chelation or low pretreatment iron load • Of patients with an LIC value available, those who died or had heart disease (n=11)
Slide 9: LIC thresholds and associated risks
LIC thresholds and associated risks FerriScan provides the accurate LIC information to ensure patient chelation therapy is optimised. LIC threshold Clinical relevance (mg Fe/g dry weight) 1.8 Upper 95% of normal 3.2 Suggested lower limit of optimal range for LICs for chelation therapy in transfusion
Slide 10: Serum ferritin is only weakly correlated with LIC
Serum ferritin is only weakly correlated with LIC There is a weak correlation between SF and LIC in the population of thalassaemia major () and sickle cell anaemia patients () Brittenham et al, Am J Hematol 1993: 42, 81-85.
Slide 11: Serum ferritin
Serum ferritin • Serum ferritin can be used for monitoring trends in patient iron loading • Serum ferritin does not give reliable information on degree of patient iron loading • Serum ferritin values do not provide the information required to optimise chelation therapy
Slide 12: FerriScan
FerriScan® • non-invasive MRI measurement of LIC • FerriScan is based on the R2-MRI imaging technique and unique patented software algorithms
Slide 13: FerriScan is a reliable accurate measure of LIC
FerriScan® is a reliable accurate measure of LIC • High sensitivity and specificity over entire range of LIC encountered • Unaffected by presence of fibrosis/cirrhosis Fibrosis stages: • More accurate than any 0 or 1 = other LIC test 2 to 4 = 5 or 6 = St Pierre et al, Blood. 2005; 105:855-861.
Slide 14: Example: FerriScan measurements to monitor iron chelation therapy
Example: FerriScan® measurements to monitor iron chelation therapy Before chelation therapy intervention Mean LIC = 16.0 After 12 months of chelation therapy intervention Mean LIC = 1.6 LIC map Low High iron iron
Slide 15: Example: Monitoring LIC with FerriScan
Example: Monitoring LIC with FerriScan® Annual measurements of LIC can be used to monitor effectiveness of chelation therapy
Slide 16: Benefits of FerriScan
Benefits of FerriScan®? • FerriScan provide an accurate LIC measurement • Annual measures can be used to optimise chelation therapy • Avoid performing an invasive liver biopsy – FerriScan has replaced the need for liver biopsies at leading pediatric clinics. • Minimise the risk of cardiac complicati
Slide 17: Why choose FerriScan?
Why choose FerriScan®? • FerriScan is regulatory approval – FDA, Health Canada, TGA, MedSafe and CE Mark • FerriScan is the most accurate LIC test available • FerriScan can be easily established on almost any MRI scanner • No additional hardware or software is required • FerriScan has a proven dynam
Slide 18: FerriScan is not difficult to implement and is readily available
FerriScan® is not difficult to implement and is readily available • FerriScan works on most MRI scanners available today • The FerriScan team provides clear instructions and on-line support to help radiologists implement the technique • FerriScan has been successfully implemented in over 22 countrie
Slide 19: FerriScan: be better informed about your patient's Liver Iron Concentration
FerriScan® be better informed about your patient’s Liver Iron Concentration
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