Inspire Medical Systems, Inc. · NYSE:INSP
Inspire Medical Systems — Wells Fargo 2025 MedTech Innovation Spotlight
14 slides from Inspire Medical Systems's conference presentation, Jun 13, 2025
Slide 1: Wells Fargo 2025 MedTech Innovation Spotlight
© 2024 Inspire Medical Systems, Inc. All Rights Reserved Inspire Medical Systems, Inc. Wells Fargo 2025 MedTech Innovation Spotlight June 13, 2025 NYSE: INSP
Slide 2: Disclaimer
Disclaimer This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts are forward-looking statements. In some cases, you can identify forward-looking statements by terms su
Slide 3: Inspire V Sensor Performance and Therapy Evolution
Current Sensor Inspire V Sensor Performance Therapy Evolution Built-in • Multiple electrodes capability • Enables new stim targets and sensing features Flexible Software Platform • Downloadable features for clinical studies and field upgrades • Future features could include posture-responsive therap
Slide 4: Inspire V Accelerometer Performance Data Presented SLEEP 2025
Inspire V Accelerometer Performance Data Presented SLEEP 2024
Slide 5: Inspire V Singapore Data Presented SLEEP 2025
Inspire V Singapore Data Presented SLEEP 2025
Slide 6: Efficacy of Inspire in Supine AHI Presented SLEEP 2025
Efficacy of Inspire in Supine AHI Presented SLEEP 2025
Slide 7: Embedded video in presentation
Closed-Loop System: Inspire V Sensing *Embedded video in presentation – please see attached transcript*
Slide 8: Inspire V Full Launch May 2025
Inspire V Full launch May 2025
Slide 9: Inspire Medical Systems, Inc.
Inspire Medical Systems, Inc. We are a medical technology company committed to enhancing patient lives through sleep innovation “Put the pat ient f i r s t and you wi l l never lose your way.” Demonstrate Operational Excellence Drive Therapy Adoption Strengthen Organizational Culture Focused on Outc
Slide 10: No mask. No hose. Just sleep.
No mask. No hose. Just sleep. www.inspiresleep.com ®
Slide 11: Video Transcript (page 1 of 4)
Closed-Loop System: Inspire V Sensing (Video Transcript, page 1 of 4) :07 With the release of Inspire 5, one of the most exciting new features is the change in how Inspires respiration sensing technology works. 0:16 With Inspire 4, respiration was detected using our proprietary pressure sensor Lead.
Slide 12: Video Transcript (page 2 of 4)
1:11 This is why Inspire is designed to turn on and off with the patient's breathing cycle. 1:16 We have already established the tongue needs to rest after stimulation. 1:21 Since we have to turn stimulation on and off to rest the tongue, does it then matter when stimulation is actually on? 1:28 Why
Slide 13: Video Transcript (page 3 of 4)
2:25 It is important to deliver stimulation before the collapse cascade of OSA begins. 2:30 Inspires sensing algorithm is designed to provide stimulation during this vulnerable period of breathing and relax the tongue during the beginning of the following exhalation cycle. 2:42 As such, INSPIRE deli
Slide 14: Video Transcript (page 4 of 4)
3:48 By inverting the sensing signal and reducing the sensitivity to breathing cycle detection, they observed worsening in ODIAHI and especially supine AHI. 4:01 These outcomes return to their treatment levels when the settings were corrected in future sleep studies, the authors concluded correct re
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