Slide 1: AZX100 Dermal Scarring Clinical Development Program
AZX100 AZX100 Dermal Scarring Clinical Development Program 14-Dec-2010 AZX100
Slide 2: Safe Harbor Statement
Safe Harbor Statement Statements in this presentation or otherwise attributable to Capstone Therapeutics regarding our business that are not historical facts are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements, whi
Slide 3: Dermal Scarring: Range of Indications
Dermal Scarring: Range of Indications Keloid Scars • Overgrowth of dense fibrous tissue • Extend beyond borders of original wound • Do not regress spontaneously • Tend to recur after excision Hypertrophic Scars • Red, itching, raised fibrous lesions • Typically do not expand beyond boundaries of ini
Slide 4: Keloid Scars
Keloid Scars
Slide 5: What are the Goals of Phase 2a?
What are the Goals of Phase 2a?
Slide 6: Phase 2a Clinical Trials - Keloid Scars
AZX100 Phase 2a Clinical Trials - Keloid Scars
Slide 7: Phase 2a Clinical Trials - Keloid Scars
AZX100 Phase 2a Clinical Trials - Keloid Scars
Slide 8: Phase 2a Results - Keloid Scars
AZX100 Phase 2a Results - Keloid Scars Summary
Slide 9: Where was AZX100 "better"?
Where was AZX100 “better”? Outcomes & Time Points at which AZX100 1.0mg/cm was “better” than placebo (not statistically significant)
Slide 10: OL-ASCAR-05 - 12-Month Analysis - 1.0 mg/cm Dose Group vs. Placebo
AZX100 OL-ASCAR-05 - 12-Month Analysis - 1.0 mg/cm Dose Group vs. Placebo Mean Scar Width (mm) by Visit by Treatment Group Not statistically significant; for illustrative purposes only
Slide 11: OL-ASCAR-05 - 12-Month Analysis - 1.0 mg/cm Dose Group vs. Placebo
AZX100 OL-ASCAR-05 - 12-Month Analysis - 1.0 mg/cm Dose Group vs. Placebo Mean Scar Maximum Elevation (mm) by Visit by Treatment Group Not statistically significant; for illustrative purposes only
Slide 12: CAPSTONE
CAPSTONE
Slide 13: Phase 2a Clinical Trials - Surgical (Trocar Site) Scars
AZX100 Phase 2a Clinical Trials - Surgical (Trocar Site) Scars
Slide 14: Phase 2a Clinical Trial in Surgical (Trocar Site) Scars
AZX100 Phase 2a Clinical Trial in Surgical (Trocar Site) Scars
Slide 15: CAPSTONE
CAPSTONE
Slide 16: Is AZX100 a Viable Candidate for Clinical & Commercial Development?
Is AZX100 a Viable Candidate for Clinical & Commercial Development?
Slide 17: Is AZX100 a Viable Candidate for Clinical & Commercial Development?
Is AZX100 a Viable Candidate for Clinical & Commercial Development?
Slide 18: NASDAQ CM: CAPS
N ASDAQ CM: CAPS www.capstonethx.com Capstone Therapeutics 1275 West Washington Street - Suite 101 Tempe, AZ 85281 (602) 286-5520