Protalix Biotherapeutics, Inc. (de) · AMEX:PLX
Protalix Biotherapeutics, Inc. (de) — Investor Presentation (February 2026)
23 slides from Protalix Biotherapeutics, Inc. (de)'s investor presentation, Feb 11, 2026
Slide 1: Protalix Biotherapeutics Corporate Presentation February 2026
1 PROTALIX BIOTHERAPEUTICS C O R P O R A T E P R E S E N T A T I O N J u n e 2024 PROTALIX BIOTHERAPEUTICS Pioneering solutions to transform the treatment of rare diseases C O R P O R A T E P R E S E N T A T I O N F e b r u a r y 2026 Exhibit 99.1
Slide 2: Forward-Looking Statements
2 Forward-Looking Statements This presentation contains forward-looking statements that involve risks and uncertainties within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Exchange Act. Forward-looking statements are neither hist
Slide 3: Experienced leadership team
3 Experienced leadership team ORI KALID, PH.D. VP of R&D Dr. Kalid brings >20 years of leadership experience in pharmaceutical R&D. Previously he was co-founder and CEO of Silverskate Bio, as well as co-founder and CEO of Pi Therapeutics. He also served at Hotaru Innovation Partners, PREDIX/EPIX Pha
Slide 4: Accomplished Board of Directors
4 Accomplished Board of Directors AMOS BAR SHALEV Director POL F. BOUDES, M.D. Director GWEN A. MELINCOFF Director AHARON SCHWARTZ, PH.D. Director ELIOT FORSTER, PH.D. Chairman DROR BASHAN President & CEO, Director SHMUEL “MULI” BEN ZVI, PH.D. Director Christian Else Director BATM logo
Slide 5: CHMP Endorsement Could Unlock Meaningful Differentiation for Elfabrio
5 CHMP Endorsement Could Unlock Meaningful Differentiation for Elfabrio® • Positive CHMP opinion supports expanded dosing flexibility in the European Union (EU) • 2 mg/kg every four weeks (E4W) for adult Fabry patients stable on enzyme replacement therapy • Final decision of European Commission (EC)
Slide 6: Protalix delivers innovations from concept to market
6 Protalix delivers innovations from concept to market Proven execution of delivering protein products for rare diseases with a pipeline for the future 1: Elfabrio has been approved for marketing in the United States, the European Union, and additional markets. Chiesi Global Rare Diseases, a busines
Slide 7: Two commercial products and a growing pipeline for the future
7 Indication Discovery and Preclinical Phase 1 Phase 2 Phase 3 Marketing Application Status Fabry Disease Approved in >20 markets, inc. US and EU Gaucher Disease Approved in >20 markets, inc. US PEGylated Uricase (PRX-115) Uncontrolled Gout Phase 2 PRX-115 trial actively enrolling Long Acting (LA) D
Slide 8: Well capitalized to advance Protalix to the next phase
8 Well capitalized to advance Protalix to the next phase CASH STREAMS FROM STRONG PARTNERSHIPS REVENUE CASH & CASH RUNWAY and OUTSTANDING SHARES $43.1M in 1-9/2025 revenue from selling goods $53M in revenue (FY 2024) $29.4M (as of 9/30/2025); no debt no warrants / anticipate cashflow positive in 1H/
Slide 9: Key upcoming milestones and catalysts
9 Key upcoming milestones and catalysts Business development activities in rare renal diseases 3 streams of revenue and projected consistent growth in the medium-term Significant milestone payments expected in mid- and long-term Continued internal R&D pipeline growth Elfabrio® Commercial partnership
Slide 10: PRX-115 in development for uncontrolled gout
10 Phase 2 Actively enrolling PRX-115 in development for uncontrolled gout
Slide 11: Uncontrolled gout: limited options and disadvantages with current therapy
11 Uncontrolled gout: limited options and disadvantages with current therapy An unsatisfied market Gout and uncontrolled gout • Metabolic disorder characterized by elevated blood urate that causes recurrent inflammatory arthritis and joint damage • Rheumatologists report that ~25% of their patients
Slide 12: The US Gout Market
12 11.3M1 5M2 1.2M2 0.3M3 0.18M3 6-8K4 The US Gout Market Treatments The market is poised to expand significantly as newer therapies and competitors enter and further expand disease awareness and reduce clinical inertia A differentiated best-in-class uricase like PRX-115 is poised to increase the ma
Slide 13: PRX-115 Phase 1 single ascending dose study
13 PRX-115 Phase 1 single ascending dose study: encouraging data supports Phase 2 Recombinant PEGylated uricase enzyme produced via ProCellEx® 13 Study Scheme Primary Endpoint: Safety and tolerability Secondary Endpoints: PK, PD (uric acid levels) Subjects with elevated uric acid N = 8 per cohort (6
Slide 14: PRX-115 best in class potential for uncontrolled gout
14 PRX-115 best in class potential for uncontrolled gout Addresses an important unmet medical need 14 Next Steps • Phase 2 study in uncontrolled gout patients actively enrolling PRX-115 Phase 1 outcome • Favorable tolerability profile • Ability to reduce uric acid levels rapidly and maintain below 6
Slide 15: PRX-115 Phase 2 double blind placebo-controlled study design
15 PRX-115 Phase 2 double blind placebo-controlled study design: actively enrolling MTX – Methotrexate Patient Population: uncontrolled gout Primary Endpoint: proportion of patients who achieve a reduction in serum uric acid (sUA) to <6.0 mg/dL for at least 80% of the time during Month 6 Secondary E
Slide 16: Commercial products
16 Commercial products Reliably partnered and delivering revenue
Slide 17: Two commercial products sustaining future growth
17 Rare autosomal recessive disorder (~1/40,000 WW) with systemic visceral and skeletal disease-causing disability and organ dysfunction Rare X-linked disorder (~1/40,000-60,000 males WW) with progressive renal, cardiac, and neurological burden Fabry disease Two commercial products sustaining future
Slide 18: Fabry disease competitive landscape
18 Fabry disease competitive landscape ~$2.1B market (2024) expected to reach over $3.4B (2030), CAGR of 8.2%1 18 Product Name Fabrazyme® Replagal® Galafold® Elfabrio® Parent Company Mechanism ERT ERT Pharmacological chaperone ERT longer half-life (pegylated) Approved for Adults & pediatric patients
Slide 19: Commitment and execution from global partnership with Chiesi
19 Commitment and execution from global partnership with Chiesi Committed Global Partner • International research-focused biopharmaceutical group with sales in excess of €3.4B in 2024 (reflecting 13% growth year-on-year) • Operating in close to 30 countries with over 7,500 employees; invested over 2
Slide 20: Growth strategy
20 Growth strategy Next phase of the company
Slide 21: Research strategy - leveraging internal strengths
21 Research strategy - leveraging internal strengths to fuel the next phase of company Proven ability to drive discovery, development, and registration of new drugs 21 Internal development Protein therapeutics Plant cell-based expression Chemical modification PEGylation, other Drug delivery Explorin
Slide 22: Protalix delivers innovation from concept to the market
22 Protalix delivers innovation from concept to the market * of the Registrant’s common stock, $0.001 par value (as of 11/1/2025) Revenues USD 53M 2024 Cash and Shares Outstanding USD 29.4M Q3/2025 ~80,421,181 shares* Debt No Debt / Warrants Growing pipeline for the next phase of the company • PRX-1
Slide 23: Protalix Biotherapeutics Corporate Presentation
23 PROTALIX BIOTHERAPEUTICS C O R P O R A T E P R E S E N T A T I O N J u n e 2024 PROTALIX BIOTHERAPEUTICS Pioneering solutions to transform the treatment of rare diseases C O R P O R A T E P R E S E N T A T I O N F e b r u a r y 2026
Protalix BioTherapeutics — Investor Presentation (February 2026) on 6ix