Trendlines Group Ltd. · SGX:42T

Trendlines — ZygoFix — Investor Presentation (November 2020)

17 slides from Trendlines's investor presentation, November 2020

  1. Slide 1: True Minimally Invasive Spinal Fusion

    TRUE MINIMALLY INVASIVE SPINAL FUSION OFER LEVY CEO Nov. 2020 www.ZygoFix.com © All rights reserved to ZygoFix

  2. Slide 2: Legal disclaimer

    Legal disclaimer IMPORTANT NOTICE This presentation has been prepared by ZygoFix Ltd. (the “Company”) solely for informational purposes. The information contained herein has been prepared to assist prospective investors in making their own evaluation of the Company and does not purport to be complet

  3. Slide 3: ZygoFix, in Brief

    ZYGOFIX, IN BRIEF ZygoFix zLOCK’s unique design enables outpatient spinal fusion with a simple and safe approach Winner of the 2017 Successful Clinical Spine Technology Outcomes at 24 Award -2019 MC Israel month F/U Gold Winner Investor (and 3 granted patents private investors) Zygofix True minimall

  4. Slide 4: Chronic Back Pain May Require Surgical Intervention

    Chronic Back Pain May Require Surgical Intervention Zygofix True minimally invasive spinal fusion| 4

  5. Slide 5: Patients fear and refrain from the current surgical offering

    Patients fear and refrain from the current surgical offering (mostly screw based implants) SI (Sacrum Ilium) Fusion Lumbar Fusion Cervical Fusion Images (left to right): (1) SI Bone (2) www.weillcornellbrainandspine.org; (3) http://www.k2m.com; Zygofix True minimally invasive spinal fusion| 5

  6. Slide 6: Opportunity

    Opportunity the market seeks a simpler, safer and less invasive solution to enable out-patient procedures Zygofix True minimally invasive spinal fusion| 6

  7. Slide 7: If you were a candidate for spinal fusion, which would you prefer?

    If you were a candidate for spinal fusion, which would you prefer placed in your back? Zygofix True minimally invasive spinal fusion| 7

  8. Slide 8: ZygoFix's zLOCK

    ZygoFix’s zLOCK: The first 3D printed spinal implant that fits itself to the individual patient’s anatomy Small, spinal implant inserted IN the joint zLOCK miniature 3D printed implant provides a simpler, safer and less invasive spinal fusion option Zygofix True minimally invasive spinal fusion| 8

  9. Slide 9: How We Do it: Our Unique Design

    How We Do it: Our Unique Design Small package – a lot of know-how Fits all shapes and • Our flexible proprietary design enables: anatomies • to bend rigid titanium • to suit all spinal joint variations • Porous design enhances bone fusion • Custom tools enable simple minimally invasive procedure Zyg

  10. Slide 10: Value Proposition

    Value Proposition Suitable to all types Minimally Invasive Simpler to Place Cost-effective of anatomies Completely 3D Feature 1 vs. 3 incisions No screw placement Adjusts to all anatomies printed Shorter procedure, 70% Less scars, less intimidating, More patients will benefit the Patient radiation,

  11. Slide 11: Successful 24 Month Follow-up

    Successful 24 Month Follow-up Entered clinical phase in April 2018 patient doing extremely well and reports no pain! I can hardly believe it... I could discharge the patient even today! Practically no blood loss Principal investigator (1 day after FIM surgery) 12-months post op. x-ray Zygofix True m

  12. Slide 12: zLOCK Applications

    zLOCK Applications zLOCK is suitable for a number of fusion applications Cervical Lumbar • Lumbar Fusion –510k [Q4/22] • Facet Fusion – [Q1/21] • SI Fusion – 510k [Q4/23] • SI Fusion – [Q4/23] • Cervical Fusion – 510k [Q4/24] • Cervical Fusion – [Q4/24] SI (sacrum ilium) Zygofix True minimally invas

  13. Slide 13: $2B Global Market Opportunity

    $2B Global Market Opportunity TAM US (Procedures) System price TAM US ($) Lumbar market breakdown Lumbar 210,000 $2,400 504M • 450,000 lumbar fusions in 2017 (US only). 3.5% CAGR -> 500,000 procedure in 2020. Cervical 145,000 $3,000 435M • 40% pedicle screws only -> 60% are suitable for zLOCK = SI 1

  14. Slide 14: Gaining Market Traction

    Gaining Market Traction Wide interest in zLOCK from interventional spine professionals: 90+ inquiries, from 22 countries, of surgeons and 2019 MassChallenge distributors interested in Israel Gold Winner use/distribution 2017 Spine Technology Continuous patient Award winner interest about inclusion i

  15. Slide 15: IP - Portfolio of 3 Patents

    IP - Portfolio of 3 Patents Unique design provides strong claims and IP! 01 02 03 Basic implant Implant design Implant Delivery design patent protecting patent System Granted in EU,China, Japan Granted in US Granted in US Pending in US, Brazil In national phase In national phase WO2017046667 WO20191

  16. Slide 16: Management

    ZygoFix Team Management Ofer Levy Uri Arnin Prof. Yizhar Floman Oded Shamir Dr. Hanna Levy CEO Co-founder. CTO Co-founder. Medical Director R&D Manager Clinical Manager 15+ years experience in Serial entrepreneur; 20+ years Chairman and Director of the 15+ years of experience in Expert in clinical t

  17. Slide 17: Thank You!

    THANK YOU! ofer@zygofix.com www.ZygoFix.com

ZygoFix — Investor Presentation (November 2020) on 6ix