Grail, Inc. · NASDAQ:GRAL
Grail — Technical Presentation (October 2025)
7 slides from Grail's technical presentation, October 2025
Slide 1: REFLECTION: Real-World Evidence Study of Multi-Cancer Early Detection Among Veterans in the VA
REFLECTION: Real-World Evidence Study of Multi-Cancer Early Detection (MCED) Among Veterans in the Veterans Affairs Healthcare System (VA) Authors: Charles Atwood, MD1; Mark S. Kindy, PhD2; Lynn M. Keenan, MD3; Jason L. Vassy, MD, MPH4; Nancy Vander Velde, MD5; Greg Holt, MD, PhD6; Teresa Filshtein
Slide 2: A Multi-Cancer Early Detection Blood Test Can Detect a Cancer Signal and Predict a Cancer Signal Origin
A Multi-Cancer Early Detection (MCED) Blood Test Can Detect a Cancer Signal and Predict a Cancer Signal Origin (CSO) The Galleri® MCED test (GRAIL, Inc., Menlo Park, CA) uses targeted methylation sequencing of cell-free DNA in the bloodstream paired with machine learning algorithms to detect a cance
Slide 3: REFLECTION Study: Real-World Experience With the MCED Test
REFLECTION Study: Real-World Experience With the MCED Test Multicenter, prospective, non-interventional, cohort study in clinical settings (NCT05205967) The objective of the ongoing REFLECTION study is to understand the real-world experience of using the Galleri MCED test in clinical settings ~14,60
Slide 4: A Diverse Population of Veterans Was Enrolled
A Diverse Population of Veterans Was Enrolled 3587 veterans have been enrolled in REFLECTION Study: VA Cohort REFLECTION at 7 61 y (median; interquartile range: 50-70 y); 38.4% ≥ 65 y VA sites as of June 30, 2024 78.6% men White (Non-Hispanic) 57.6%, Black/African American 3355 veterans with 1-year
Slide 5: The 1-Year PPV in the VA Cohort Is Comparable to PPVs From Other Clinical Studies
The 1-Year PPV in the VA Cohort Is Comparable to PPVs From Other Clinical Studies of This MCED Test With Up to 1 Year of Follow-Up 3355 Analyzable Participants Completed 1-Year Follow-up: PPV Specificity (95% CI) (95% CI) No Cancer Signal Detected Cancer Signal Detected N=3325 N=30 50.0% 99.5% REFLE
Slide 6: A Variety of Cancers Were Diagnosed Within 1 Year of a Positive MCED Test
A Variety of Cancers Were Diagnosed Within 1 Year of a Positive MCED Test Result 12 Participants 3 Participants had 93.3% had had12Solid SolidTumors Tumors Hematologic Malignancies CSO Accuracy (n=14/15) Lung (n=2) Breast (n=1) Myeloma (n=1) 57.1% Pancreas (n=1) Stomach (n=1) Kidney (n=1) Lymphoma o
Slide 7: Conclusions
Conclusions REFLECTION has successfully Cancer signal detection rate, Longer-term data will recruited a diverse population specificity, and PPV in this provide cancer outcomes of veterans cohort of veterans were (status, type, and stage) and consistent with other clinical veteran-reported experience