Cytokinetics, Incorporated · NASDAQ:CYTK
Cytokinetics — Investor Presentation (May 2026)
63 slides from Cytokinetics's investor presentation, May 2026
Slide 1: Cytokinetics
G . Cytokinetics’
Slide 2: Forward-Looking Statements
Forward-Looking Statements This presentation contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Cytokinetics disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act's safe ha
Slide 3: Our Mission
Our Mission To bring forward new medicines to improve the healthspan of people with devastating cardiovascular and neuromuscular diseases of impaired muscle function. 3
Slide 4: Now Available
Now Available FDA-approved for the treatment of adults with symptomatic oHCM to improve functional capacity and symptoms FDA: U.S. Food & Drug Administration; oHCM: obstructive hypertrophic cardiomyopathy Please see full Prescribing Information, including Boxed WARNING and Medication Guide 4
Slide 5: A Commitment to Muscle-Directed Medicines
A Commitment to Muscle-Directed Medicines Drug Therapeutic Area Approved & (Clinical Trial) Research Pre-Clinical Phase 1 Phase 2 Phase 3 Commercialized oHCM* Approved MYQORZO® in US, China & EU** SEQUOIA-HCM oHCM (vs. metoprolol) Aficamten MAPLE-HCM Pediatric oHCM Aficamten CEDAR-HCM nHCM Aficamten
Slide 6: Positioned for Launch Velocity & Sustainable Growth
Positioned for Launch Velocity & Sustainable Growth COMMERCIAL RESEARCH & DEVELOPMENT STRONG FINANCIAL POSITION Specialty Muscle-directed platform with multi-program pipeline Cardiology ~$1.1B Franchise cash, cash equivalents & investments (as of 3/31/26) sNDA for aficamten based on MAPLE-HCM under
Slide 7: Innovation, Ignition, Impact (Vision 2030)
INNOVATION Advance 2 approved products across 3 indications and 10 NMEs in our pipeline IGNITION Achieve broad access and rapid use of our medicines in >15 countries throughout North America and Europe IMPACT Reach >100,000 patients globally with our medicines INSPIRATION Foster a patient-centric cu
Slide 8: Strong Start to 2026
Strong Start to 2026 Q1 2026 & Recent Highlights 2026 Key Activities • MYQORZO® now approved in U.S., EU and China • Continue U.S. commercial launch of MYQORZO • Positive topline results from ACACIA-HCM reported in April 2026 • Launch MYQORZO in Germany in Q2 • U.S. commercial launch of MYQORZO unde
Slide 9: Building a Specialty Cardiology Franchise
Building a Specialty Cardiology Franchise 9
Slide 10: Building Specialty Cardiology Business for High ROI
Building Specialty Cardiology Business for High ROI Concentrated Prescribers Higher Revenue Per Prescriber Opportunity To Grow ~80K cardiologists/PCPs treat CV diseases Market Through Diagnosis ~10K $$$$/ 50 % cardiologists HCP treat ~80% HCM $/HCP General Specialty Distribution Limited to Different
Slide 11: Addressing Difficult to Treat Populations Within Heart Failure
Addressing Difficult to Treat Populations Within Heart Failure Specialty cardiology franchise strategy applies to markets with similar characteristics HFrEF HFpEF HCM Severely Supranormal EF reduced EF Opportunity for MYQORZO® Addressing underserved segment Expanding into adjacent population* (afica
Slide 12: Potential for Multiple Specialty Cardiology Launches
Potential for Multiple Specialty Cardiology Launches Drug Potential Candidate Indication 2024 2025 2026 2027 2028 2029 2030+ oHCM MYQORZO® oHCM Mono (aficamten) (MAPLE-HCM) nHCM (ACACIA-HCM) Omecamtiv HFrEF Mecarbil Ulacamten HFpEF Estimated date of potential future launch of each candidate for the
Slide 13: MYQORZO (aficamten) Clinical Evidence
MYQORZO (aficamten) ® Clinical Evidence Prescribing Information Medication Guide 13
Slide 14: About oHCM
About oHCM Left Ventricular Outflow Tract (LVOT) • HCM causes the heart muscle to abnormally thicken. • In obstructive HCM (oHCM), the thickened muscle causes the left ventricle to become smaller, stiffer and less able to relax and fill with blood.1–4 • In oHCM, obstruction of the LVOT, blocks blood
Slide 15: MYQORZO Inhibits Cardiac Myosin Motor Activity
MYQORZO® Inhibits Cardiac Myosin Motor Activity oHCM causes cardiac MYQORZO binds to and hypercontractility, inhibits cardiac myosin, impaired cardiac relaxation & reducing cardiac contractility increased energy consumption & LVOT obstruction MYQORZO Actin Active myosin head Deactivated myosin head
Slide 16: SEQUOIA-HCM: Pivotal Phase 3 Trial
SEQUOIA-HCM: Pivotal Phase 3 Trial Primary endpoint: Change in pVO2 by CPET from baseline to Week 24 Randomization Aficamten + SoC End of Study Patients with Screening oHCM treated Secondary objectives include measuring with SOC with post-Valsalva 1 change in KCCQ & improvement in peak LVOT-G ≥50 mm
Slide 17: SEQUOIA-HCM: Pivotal Phase 3 Trial in oHCM
SEQUOIA-HCM: Pivotal Phase 3 Trial in oHCM Significant improvement in exercise capacity and symptoms compared to placebo Treatment with MYQORZO for 24 weeks also significantly improved: Gradients Absolute Change from Baseline to Week 24 -50 mmHg placebo-corrected change in post-Valsalva LVOT-G (p<0.
Slide 18: SEQUOIA-HCM: Safety Data
SEQUOIA-HCM: Safety Data MYQORZO Placebo Event, n (%) (n=142) (n=140) Overall AEs 105 (73.9) 99 (70.7) Headache 11 (7.7) 10 (7.1) Hypertension 11 (7.7) 3 (2.1) Palpitations 10 (7.0) 4 (2.9) AEs with ≥5% incidence Upper respiratory infection 9 (6.3) 12 (8.6) COVID-19 8 (5.6) 9 (6.4) There were no ser
Slide 19: MAPLE-HCM: Phase 3 Monotherapy Trial in oHCM
MAPLE-HCM: Phase 3 Monotherapy Trial in oHCM Aficamten superior to standard-of-care beta blocker metoprolol Relative to metoprolol, aficamten also improved: Mean Change from Baseline to Week 24 in pVO2 Gradients LSM difference of -30 mmHg in resting LVOT-G (p<0.0001)1 22 LSM difference of -35 mmHg i
Slide 20: MAPLE-HCM: Safety
MAPLE-HCM: Safety Aficamten (n=88) Metoprolol (n=87) Patients with any SAE 7 (8.0) 6 (6.9) Patients with any AE that led to early treatment withdrawal of aficamten or 1 (1.1) 3 (3.4) metoprolola Patients with AE that led to temporary interruption of aficamten or metoprolol 1 (1.1) 1 (1.1) Patients w
Slide 21: Integrated Safety Analysis in oHCM
Integrated Safety Analysis in oHCM Analysis represents nearly 700 patient-years of exposure to aficamten Low incidence of LVEF <50%; no occurrences associated with clinical HF were corroborated by core lab, and all were Safety Events of Interest successfully managed by dose reduction Cumulative af
Slide 22: MYQORZO (aficamten) Commercial Launch
MYQORZO (aficamten) ® Commercial Launch Prescribing Information Medication Guide 22
Slide 23: Opportunity for CMIs to Treat Symptomatic oHCM Patients
Opportunity for CMIs to Treat Symptomatic oHCM Patients Evolving Understanding of Prevalence Rates for HCM Subtypes: oHCM and nHCM HCM estimated prevalence ~0.3% in the general population ~850k (approximately 1 in 350 individuals)1 Two HCM subtypes: obstructive HCM (oHCM) and nonobstructive HCM
Slide 24: $10B Potential Market of CMI-Eligible Patients
$10B Potential Market of CMI-Eligible Patients Diagnosis of HCM anticipated to grow 5x the rate of the general U.S. population US and EU HCM Patients in 2035 Illustrative 880K1,2 Expected global population of diagnosed patients with Projected Diagnosed HCM Patients oHCM & nHCM (5x the growth rate of
Slide 25: Initial Focus on High Volume CMI Prescribers
Initial Focus on High Volume CMI Prescribers HCPs for Personal and Non-Personal Engagement Other CMI non-users At launch, we have a ~21K Non-personal promotion greater emphasis on the top CMI prescribers to build share and depth of CMI nonusers who treat HCM ~8K prescribing Personal promotion ~40%
Slide 26: HCP & Patient-Directed Promotional Campaigns Activated
HCP & Patient-Directed Promotional Campaigns Activated For HCPs For Patients Non-Personal Social Office Resources HCP Patient Support Website Materials Patient Website Peer-to-Peer In-Office Digital Ads Patient Materials Email HCP: healthcare professional Please see full Prescribing Information, inc
Slide 27: Highly Experienced Sales Team Deployed
Highly Experienced Sales Team Deployed 125 experienced Cardiovascular Account Specialists and Area Business Managers 21 14 4 5 Average years Average years of Average years Average number of industry cardiovascular rare disease of President’s experience experience experience Awards for sales performa
Slide 28: Key Launch Drivers to Achieve High Share and Grow Category
Key Launch Drivers to Achieve High Share and Grow Category Clinical REMS Rapid & sustained Flexibility to rapidly titrate as early as 2 weeks symptom improvement and reduction in Dose may be titrated after each echocardiogram obstruction Echocardiogram assessment within 2 to 8 weeks No monthly
Slide 29: Key Features of REMS Monitoring Schedule
Key Features of REMS Monitoring Schedule for First Year of Therapy Estimated Titration Regimen Across Dose Range MYQORZO® CAMZYOS® Process Step 5 mg 10 mg 15 mg 20 mg [within 12 months] Increase dose after Week 12 if Up-titration Increase dose after each echo, Echocardiogram* 3 4 5 6 LVEF ≥55% and V
Slide 30: MYQORZO & You: Bespoke Treatment Experience
MYQORZO & You : Bespoke Treatment Experience Patient Activation & Engagement Support investigating patient’s health Access & insurance benefits, OOP cost, Prior Reimbursement Authorization and/or Appeal criteria & submission Free drug supply during trial period for Free Trial eligible government-ins
Slide 31: Market Access Strategy
Market Access Strategy Grow CMI class & compete via clinical differentiation Securing Market Access MYQORZO® Q1 Payor Mix Q1 2026 Ongoing payor engagement Secured comparable access for Q2 2026 nearly 90% of Medicare lives, Commercial expect parity by end of Q2 2026 34% Medicare* Expect to reach 50%
Slide 32: Measuring Launch Velocity: Key Metrics
Measuring Launch Velocity: 3 Key Metrics Potential to reach >50% share of new patients by the end of 2026 Breadth and depth of HCP Volume of patients prescribing of MYQORZO® on MYQORZO Number of HCPs Volume of MYQORZO Volume of patients prescribing MYQORZO prescriptions on MYQORZO each HCP writes HC
Slide 33: Key Metrics: Breadth & Depth of HCP Prescribing
Key Metrics: Breadth & Depth of HCP Prescribing Potential Leading Indicator of Breadth of HCP Prescribing Q1 Depth of HCP Prescribing Future Prescribing As of 3/31/26 1,400+ As of 3/31/26 As of 3/31/26 As of 4/30/26 2.4 >275 >425 Average prescriptions written per HCP REMS-certified HCPs HCPs prescri
Slide 34: Key Metrics: Volume of Patients
Key Metrics: Volume of Patients Volume of Patients Paid Drug in Q1 As of 3/31/26 As of 4/30/26 >70% 680 1,100 Patients on therapy with a paid prescription* Patients Prescribed MYQORZO® <2 weeks Average time to convert to paid prescription Source: MYQORZO internal patient prescription data through Ap
Slide 35: Precedents for Next-In-Class Success & Category Growth
Precedents for Next-In-Class Success & Category Growth With differentiated product profile, ATTR Class TRx has increased since Attruby Eliquis® generated 1.6x more prescriptions CMI market poised for growth3 launch than Xarelto® Oral anticoagulants Pradaxa® (2010), Xarelto (2011), Eliquis (2012) app
Slide 36: Advancing Global Availability in 2026
Advancing Global Availability in 2026 Pending Regulatory Clinical Trials Ongoing United States Approval Approved by FDA for adults with symptomatic oHCM to improve functional capacity and symptoms LAUNCHED JAN 2026 Canada New Drug Submission China under review; expect Japan to receive decision in Ph
Slide 37: ACACIA-HCM: Pivotal Phase 3 Trial in nHCM
ACACIA-HCM: Pivotal Phase 3 Trial in nHCM • Trial enrolled over 516 symptomatic Patients with: Randomization nHCM patients Aficamten End of Study Symptomatic N = 420 Screening (1:1) (NYHA Class (EOS) • Dual primary endpoint: change in II/III) nHCM, KCCQ Clinical Summary Score and peak VO2 from basel
Slide 38: ACACIA-HCM: Topline Results
ACACIA-HCM: Topline Results Full results to be presented at upcoming medical meeting Change from Baseline to Week 36 Aficamten vs Placebo Primary Endpoints p-value LSM (95% CI) LSM (95% CI) Aficamten Placebo KCCQ-CSS 11.4 (9.6 – 13.2) 8.4 (6.6 – 10.2) 3.0 (0.5 - 5.5) 0.021 pVO2 (ml/kg/min) 0.64 (0.3
Slide 39: ACACIA-HCM: Topline Results
ACACIA-HCM: Topline Results Robust & consistent improvements throughout treatment period LS Mean Change from Baseline in KCCQ-CSS Change from Baseline to Week 36 in pVO2 Washout Mean Change from Baseline to Week 36 (ml/kg/min) 1.0 Mean Change from Baseline in KCCQ-CSS Titration 0.5 Primary endpoint
Slide 40: ACACIA-HCM: Topline Results - Safety
ACACIA-HCM: Topline Results - Safety Full results to be presented at upcoming medical meeting LVEF <50%: 27 (10%) on aficamten vs. 2 (1%) on placebo; Serious Adverse Events (SAEs): 2 participants on aficamten had a serious AE of HF associated with LVEF <50% No new safety signals identified in ACACIA
Slide 41: FOREST-HCM: 96-Week Open-Label Data in nHCM
FOREST-HCM: 96-Week Open-Label Data in nHCM Analysis of 34 patients enrolled in FOREST-HCM after REDWOOD-HCM Cohort 4 No early treatment discontinuations, with sustained reductions in symptom burden 79% of patients improved by at least one NYHA Functional Class Mean increase in KCCQ-CSS of 11.
Slide 42: Omecamtiv Mecarbil
G Cytokinetics’ Omecamtiv Mecarbil Omecamtiv mecarbil is an investigational agent and has not been approved for use by the U.S. Food & Drug Administration (FDA) or any regulatory agency. The safety and effectiveness of this product have not been established. 42
Slide 43: Omecamtiv Mecarbil: Potential for High-Risk Severe HF Patients Despite GDMT
Omecamtiv Mecarbil: Potential for High-Risk Severe HF Patients Despite GDMT Efficient, pragmatic Phase 3 clinical trial High Unmet Need Ph 3 clinical trial results in 8,000 patients point to important treatment benefit The large and growing heart failure population faces frequent Planning hospitaliz
Slide 44: GALACTIC-HF: Clinical Trial Overview
GALACTIC-HF: Clinical Trial Overview Phase 3 clinical trial Event-driven clinical trial; 8,256 patients randomized in 35 countries at 944 clinical trial sites Chronic HFrEF Patients Randomization 1:1 Currently hospitalized for Omecamtiv mecarbil + Standard HF Therapy End of Study primary reason of H
Slide 45: GALACTIC-HF Primary Composite Endpoint
Primary Composite Endpoint 50 Placebo HR = 0.92 45 (95% CI, 0.86–0.99) 40 Omecamtiv Cumulative incidence, % P = 0.025 mecarbil 35 30 CV Death 25 HR = 1.01 (95% CI, 0.92–1.11) P = 0.86 20 Omecamtiv 15 mecarbil 10 5 0 0 6 12 18 24 30 36 Patients Months (30 days) since randomization at risk, n Placebo
Slide 46: Benefit Observed to Increase as Baseline LVEF Decreased
Benefit Observed to Increase as Baseline LVEF Decreased Incidence of Primary Composite Endpoint Relative Treatment Effect on Primary Endpoint 60 50 Placebo 1.2 Incidence Rate (per 100 py) 40 Treatment Effect (Ratio) Treatment 1.0 Effect 30 Omecamtiv 0.8 mecarbil 20 0.6 4,456 patients 3,776 patients
Slide 47: Large Treatment Effect in Easily Defined HF Population
Large Treatment Effect in Easily Defined HF Population Nom N Hazard Ratio (95% CI) ARR p-value All Patients 8232 0.025 2.1 LVEF <30% 4704 <0.001 4.9 + Hosp <3 mos 2836 <0.001 6.2 + SBP <110 1881 0.004 7.2 + Class III/IV 2249 <0.001 8.9 + NT-proBNP ≥1000 pg/mL 2852 <0.001 8.8 0.6 0.7 0.8 0.9 1 1.1 1.
Slide 48: Phase 3 Confirmatory Clinical Trial Design (COMET-HF)
Phase 3 Confirmatory Clinical Trial Design Currently enrolling COMET-HF: Confirmation of Omecamtiv Mecarbil Efficacy Trial in Heart Failure 2-week washout period LVEF < 30% 2-week run-in period • Primary endpoint: time to within 6 mo Omecamtiv Mecarbil + Standard of Care CV death, HF events, Direct
Slide 49: Large and Growing Target Patient Population in US
Large and Growing Target Patient Population in US Prevalence in Adults (18+, USA) 2020 Estimates 2029 Estimates 7.1M1 8.6M3 Heart Failure Including HFpEF 3.5M2 4.3M3 HFrEF Population 2.4M2 2.8M3 HFrEF Patients with EF<30% ~720K4 ~840K4 High risk HF patients with EF<30% Proposed Cardiac Function Mark
Slide 50: Higher Event Rate & Costs in Patients with Severely Reduced EF
Higher Event Rate & Costs in Patients with Severely Reduced EF Accounts for ~60% of HFrEF hospitalizations5 35% of patients with severely reduced EF re-hospitalized within 1 year6 $15,493 per HF re-hospitalization7 Direct costs from HF re-hospitalizations projected to increase from $3.9 billion in 2
Slide 51: Ulacamten (CK-586)
G Cytokinetics’ Ulacamten (CK-586) Ulacamten is an investigational agent and has not been approved for use by the U.S. Food & Drug Administration (FDA) or ar regulatory agency. The safety and effectiveness of this product have not been established. 51
Slide 52: Heart Failure with Preserved Ejection Fraction (HFpEF)
Heart Failure with Preserved Ejection Fraction (HFpEF) Despite broad use of standard treatments & advances in care, the prognosis for patients with HF is poor1 ~75% ~84% HFpEF patients will HFpEF patients will Subset of HFpEF patients Significant increase Lifetime healthcare costs die within five ye
Slide 53: Ulacamten: Distinct Mechanism of Action from Aficamten
Ulacamten: Distinct Mechanism of Action from Aficamten “Fewer hands pulling on the rope” Before Ulacamten After Ulacamten Ulacamten Mechanochemical domain ATP Post-Powerstroke State Actin sliding Actin sliding ATP: adenosine triphosphate Ulacamten is an investigational drug and is not approved by an
Slide 54: Ulacamten: Shallow In Vivo Concentration-Response
Ulacamten: Shallow In Vivo Concentration-Response Ulacamten has a shorter half-life than aficamten Pharmacodynamic window Fractional shortening IC50 /IC10 ratio mavacamten 2.8x aficamten 9.9x ulacamten 9.3x IC10: plasma concentration at 10% relative reduction in fractional shortening IC50: plasma co
Slide 55: Phase 1 Data Support Advancement to Phase 2 Clinical Trial
Phase 1 Data Support Advancement to Phase 2 Clinical Trial Phase 1 study design: 7 SAD cohorts (10 mg to 600 mg) & 2 MAD cohorts (100 & Change in LVEF vs. 200 mg once daily), 10 participants each Plasma Concentration Ulacamten Plasma (mean [SD]) over time after single ascending doses of ulacamten Co
Slide 56: Phase 2 Study Schema (AMBER-HFpEF)
Phase 2 Study Schema Currently enrolling AMBER-HFpEF: Assessment of CK-586 in a Multi-Center, Blinded Evaluation of Safety & Tolerability Results in HFpEF 6 WEEKS 6 WEEKS 2 weeks 1 Enrolling HFpEF SoC + Placebo Cohort 1 patients with: n=24 Washout SoC + 150 mg ulacamten SoC + 300 mg ulacamten • LVEF
Slide 57: Ulacamten: Focusing on Patients with HFpEF and EF ≥60%
Ulacamten: Focusing on Patients with HFpEF and EF ≥ 60 7.9M 4.0M (2024) 1.0M (EF>65) to 2.0M (EF > 60) Heart Failure Prevalence in 2024, US 50% of HF with HFpEF (EF ≥ 50%) ~20% of HF with EF ≥ 60% 2024 prevalence calculated using published, historic estimate and projected to 2024 using age adjusted
Slide 58: Ulacamten May Address Unmet Needs of HFpEF Patients
Ulacamten May Address Unmet Needs of HFpEF Patients Proposed Mechanistic Benefits Target Product Profile • Statistically significant reduction in composite of mortality and • Ulacamten may benefit cardiac relaxation hospitalization outcomes during diastole • Oral QD tablet • Ulacamten may reduce sym
Slide 59: Financials & Milestones
Cytokinetics’ ——)EMhi iéaé sé&BdM SS Financials & Milestones
Slide 60: Strong Financial Position
Strong Financial Position Well-capitalized to execute launch & advance R&D pipeline ~$1.1B in cash, cash equivalents and investments as of March 31, 2026 $760M in net proceeds from our May 2026 public offering of Recent financing ~11.3M shares of common stock at a price of $71.00 per share Further a
Slide 61: 2026 Financial Guidance
2026 Financial Guidance Guidance Issued on Feb. 24, 2026 GAAP Combined R&D and SG&A Expense $830M to $870M Non-cash stock-based compensation expense included in $130M to $120M GAAP Combined R&D and SG&A Expense The financial guidance does not include: 1) collaboration expenses which can include reim
Slide 62: 2026 Expected Milestones
2026 Expected Milestones Omecamtiv Mecarbil Ulacamten Meet with regulatory authorities to discuss results from ACACIA-HCM & plans for submitting sNDA Launch MYQORZO in Germany in Q2 2026 Complete enrollment in sNDA for MAPLE-HCM PDUFA date Continue enrollment in Cohort 1 of November 14, 2026 COMET-H
Slide 63: Thank You
THANK YOU 63