Inmune Bio Inc. · NASDAQ:INMB
Inmune Bio — Technical Presentation (July 2020)
13 slides from Inmune Bio's technical presentation, Jul 13, 2020
Slide 1: Harnessing the Power of the Innate Immune System
HARNESSING THE POWER OF THE INNATE IMMUNE SYSTEM Modulating an Innate Immune Response Against Diseases IN MB XPro1595 KOL Webinar on Alzheimer’s July 14, 2020, 8AM EST
Slide 2: Forward Looking Statements
FORWARD LOOKING STATEMENTS This presentation contains “forward - looking statements” Forward - looking statements reflect our current view about future events . When used in this presentation, the words “anticipate,” “believe,” “estimate,” “expect,” “future,” “intend,” “plan,” or the negative of the
Slide 3: Phase 1b Trial in Alzheimer's: Design and Study Goal
DESIGN ▪ Multiple dosing cohorts ▪ Weekly XPro1595™ SubQ injections for 3 months ▪ Biomarkers of neuro inflammation at 0 and 12 weeks STUDY GOAL Demonstrate peripheral administration of XPro1595 reduces biomarkers of neuroinflammation P atients with biomarkers of inflammation Neuroinflammation measu
Slide 4: White Matter Free Water: A Biomarker for Neuroinflammation
WHITE MATTER FREE WATER A Biomarker For Neuroinflammation Free water = edema/swelling = inflammation
Slide 5: Free Water Neuroinflammation Is Increased in Alzheimer's Patients
Dumont et al Descoteaux Frontiers in Aging Neuroscience 2019 FREE WATER NEUROINFLAMMATION IS INCREASED IN ALZHEIMER’S PATIENTS
Slide 6: Neuroinflammation Continues to Increase Over Time and Correlates With Amyloid
NEUROINFLAMMATION CONTINUES TO INCREASE OVER TIME AND CORRELATES WITH CHANGES TO AMYLOID Dumont et al Descoteaux Frontiers in Aging Neuroscience 2019
Slide 7: Neuroinflammation – Free Water White Matter
NEUROINFLAMMATION – FREE WATER WHITE MATTER Safe White Matter Mask Arcuate fasciculus Uncinate fasciculus , Inferior fronto - occipital fasciculus , Splenium of the corpus callosum , Inferior longitudinal fasciculus Inferior longitudinal fasciculus , Uncinate fasciculus Measures Whole brain inflamma
Slide 8: XPro1595 Reduces Whole Brain Neuroinflammation
XPRO1595 REDUCES WHOLE BRAIN NEUROINFLAMMATION
Slide 9: XPro1595 Reduces Neuroinflammation Within the Arcuate Fasciculus
XPro1595 reduces neuroinflammation within the
Slide 10: Arcuate Fasciculus and Language Processing
Arcuate Fasciculus Premotor cortex Broca’s area Wernicke's area The arcuate plays a key role in language processing – the ability to understand or express speech
Slide 11: Summary
SUMMARY ▪ Neuroinflammatory biomarkers assessed by free water white matter in 6 AD patients ▪ N=3 at 0.3 mg/kg of XPro1595 ▪ N=3 at 1.0 mg/kg of XPro1595 ▪ Dose - dependent reduction in whole brain neuroinflammation (“safe mask free water”) ▪ A more focused analysis shows a 40.6% reduction neuroinfl
Slide 12: Questions & Answers
12 Clinical Trial to Test Neuroinflammation as the Common Denominator of ALZHEIMER’S DISEASE Questions & Answers
Slide 13: Contact Us
CONTACT US 13 HARNESSING THE POWER OF THE INNATE IMMUNE SYSTEM INMB INmune Bio Inc. 1200 Prospect Str. Suite 525 La Jolla, CA 92037 (858) 964 - 3720 www.inmunebio.com THANK YOU FOR YOUR PARTICIPATION