Immutep Ltd · ASX:IMM

Immutep — Prima BioMed — Shareholder Meeting (April 2013)

14 slides from Immutep's shareholder meeting presentation, Apr 25, 2013

  1. Slide 1: Orchestrating Cellular Therapy Clinical Trials Across 15 Countries

    Exhibit 99.1 PRIMA Australian ASX/Media 24 PRESENTATION SYDNEY, will meeting Dr. accomplishments About ENDS develop cancer For USA Ms. +1 Australia +61 Europe Mr. +49 Prima Phone: ABN: www.primabiomed.com.au April (919) Gargosky Axel further James Jessica deliver (0) Investor/Media: BioMed 90 Prima

  2. Slide 2: Outline

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  3. Slide 3: Why discuss clinical trials today / ovarian cancer unmet need

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  4. Slide 4: Why Mucin 1 as a target for immunotherapy

    Why •Mucin •It Nasopharyngeal •The Reference:Am •Mucin Differences fewer) PRIMA 3 Alteration Stimulation Mucin Up is to over mucin Target sugar 1a1BIOMED 1immunotherapy 40-fold isexpressed selected in a1Mucin chains. of cell found cellular the J the Clin 100% increase surface structure as 1? immune

  5. Slide 5: CVac mechanism and Canvas clinical development overview

    Manufacturing MNCs DCs The Mechanism Mucin Cvac T CVac Phase 1 (breast Oesophageal) 2 progressed 2/3 after PRIMA Canvas 4 CAN-001 CAN-002 CAN-003 CAN-003x cells CAN-004 DCs are 1st administered Overview activates Clinical Protocol 11-antigen (white separated target kill ovarian,fallopian BIOMED line

  6. Slide 6: CAN-004 Randomized Double-Blinded Placebo-Controlled Trial of CVac

    Outline 1. 2. 4. 3. evaluations CAN-004 A PRIMA Chemotherapy 5 Randomized, Background Introduction Ovarian Mucin Clinical CAN-004 Design Organogram CMO Blood CANVASBIOMED Collection 1and /Development cancer CANVAS update Duration Prima of Double-Blinded, systems Centers and BioMed accomplishments Pl

  7. Slide 7: CAN-004 Organogram Overview

    ••Stage CAN-004 IWRS, CMOs Unblinded Leukapheresis Histopathology Immuno-specialty Radiology Global Reg. CRO UA, PRIMA 6 Will Screening 1:1 6800 Goal Started doses BY, Consultants randomization CRO dosed include –III/IV PM Scheduler, BIOMED compare Q1 US inProject (CANVAS) consultant DM CRO (~1000 4

  8. Slide 8: Contract Manufacturing Organization (CMO) Selection

    Contract (CMO) – •Comparability PRIMA 7 Achieved Training These This 3Selection Regional CMO Overseen Full consecutive, has scale oversight protocols were BIOMED manufacturing demonstrated selection comparability hands-on development selected Between successful and were review oftraining after accep

  9. Slide 9: Vendor Qualification and Scaled Manufacturing

    •Raw Qualification There clinical Legal Specific Training PRIMA 8 Vendor Country Scaled Planning Materials and issites, BIOMED aup Documentation –selection specific similarity contracts for clinical manufacturing Inspections –careful PSSVimport process specific, /inBudgets scale Clinical cellular –o

  10. Slide 10: Blood Collection and Shipping Logistics

    •We around •The MNC •Qualified •Linked ••Managed PRIMA 9 Established have logistics Collection Packaging the BIOMED interface implemented through the shipping globe amanagement successful global customized and Scheduling ofshipping under many and Shipping automated cold country temperate parties pac

  11. Slide 11: Labeling

    •We Labeling •Labels •Globally Final •Established •Qualified ••Linked •Managed PRIMA 10 Managed have Product are BIOMED interface developed accepted the shipping import generated also aShipping global customized integrated of and in under many region and from multiple customs country temperate packa

  12. Slide 12: CANVAS Outline: Clinical Footprint

    CANVAS Outline 4. 1. 2. 4.Blood 3. PRIMA 11 Background Introduction Ovarian Mucin Clinical CAN-004 Design Organogram CMO CANVASBIOMED Collection 1and Clinical clinical Development cancer update Duration Prima of systems sites Footprint Centers and BioMed Prima accomplishments Plan / Clinical offices

  13. Slide 13: Accomplishments

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  14. Slide 14: Accomplishments and Thank You

    Accomplishments •As IThank PRIMA 13 Approved would 30patients 743ofpatients clinical April you be BIOMED delighted for have 15 by centers consented your regulators been CAN-004 attention activated todosed to address in participate; 10bycountries your Primaquestions 32and patients (including allowed

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