Agilent Technologies, Inc. · NYSE:A

Agilent Technologies — Technical Presentation (May 2010)

18 slides from Agilent Technologies's technical presentation, May 4, 2010

  1. Slide 1: Low Thermal Mass and Capillary Flow Technology for Faster Cycle Times

    5/3/2010 Welcome to NEW “Chromatography Tips & Trick” India Seminar tour Low Thermal Mass and Capillary Flow Technology for Faster Cycle Times Abhijit Pal Marketing Program Manager , India Chemical Analysis Solution Life Sciences and Chemical Analysis Agilent Technologies , India Goa 4 th May , 2010

  2. Slide 2: Defining Productivity

    5/3/2010 Defining Productivity • More analyses per unit time . . . – Faster and more efficient separations – Shorter analysis cycle time (time from injection to injection) – Reduced requirement for sample preparation • with consistently better results . . . – Quantitative: accuracy, precision, detec

  3. Slide 3: Capillary Flow Technology Suite

    5/3/2010 Capillary Flow Technology • Proprietary technology for GC IN OVEN flow manipulation • Benefits • Examples – Backflush – QuickSwap – Deans Switch (Heart-cutting) – Splitters Capillary Flow Technology Suite • Jan 2007 Significance of Capillary Flow Technology • Customer survey #1 in customer

  4. Slide 4: Improvements with Agilent 7890A GC Capillary Flow Technology

    5/3/2010 Improvements with Agilent 7890A GC • Proven in Agilent 6890 GC • Improvements in Agilent 7890 GC – New capabilities – Easier to set-up and operate – Backflush user interface in software • Improvements in support – Application notes – AE training – CE training GOAL: Widespread lockout for Ag

  5. Slide 5: Obtaining Faster GC, GC/MS Analytical Cycle Times

    5/3/2010 Obtaining Faster GC, GC/MS Analytical Cycle Times – A Variety of Approaches to Fit Your Lab and Your Needs Pre-Run Chromatographic Post-Run Post-Run ALS Set-Up Run Bake-Out Cool-Down Group/Presentation Title Agilent Restricted Month ##, 200X Obtaining Faster GC, GC/MS Analytical Cycle Times

  6. Slide 6: Obtaining Faster GC, GC/MS Analytical Cycle Times

    5/3/2010 Obtaining Faster GC, GC/MS Analytical Cycle Times – A Variety of Approaches to Fit Your Lab and Your Needs Pre-Run Chromatographic Post-Run Post-Run ALS Set-Up Run Bake-Out Cool-Down Included “ALS Sample Overlap” 7890 GC in in ChemStation SW Faster Cool-down HW/SW Faster GC Column Selection

  7. Slide 7: Milk Extract Backflush

    5/3/2010 Milk Extract It took additional 33 mins and column to 320oC to remove these high boilers. 5 10 15 20 25 30 35 40 45 50 55 60 65 70 min Group/Presentation Title Agilent Restricted Month ##, 200X Backflush During GC Run Split Vent Aux EPC Trap 4 psi S/S Inlet MSD 25 psi Purged CFT Column Devi

  8. Slide 8: Backflush Milk Extract

    5/3/2010 Backflush During GC Run Split Vent Aux EPC Trap 4 psi S/S Inlet MSD 25 psi Purged CFT Column Device After GC Run Split Vent Aux EPC Trap 45 psi S/S Inlet MSD 1 psi Purged CFT Column Device Group/Presentation Title Agilent Restricted Month ##, 200X Milk Extract It took additional 33 mins and

  9. Slide 9: Benefits of Backflushing GC and GC/MS

    5/3/2010 Benefits of Backflushing – More samples/day/instrument – Better quality data – Lower operating costs – Less frequent and faster GC & MSD maintenance – Longer column life – Less chemical background – Available for Agilent 6890/7890 Group/Presentation Title Agilent Restricted Month ##, 200X G

  10. Slide 10: Each Purged Capillary Flow Device Has Dual Use

    5/3/2010 Each Purged Capillary Flow Device Has Dual Use Backflushing – Removes heavies from column Column Effluent - Plus - QuickSwap - Remove column w/o venting MSD – Air & H2O blocked Transfer – Safe disconnection of column from inlet Line for inlet maintenance – Reversed flow through column durin

  11. Slide 11: Pesticides: Three Way Splitter with Makeup

    5/3/2010 Pesticides: Three Way Splitter with Makeup 1X method with 1:1:0.1 split FPD:MSD:ECD Phosphorus FPD 3-Way Auto-sampler Splitter with AUX EPC Makeup uECD 3.8 psig Column 5975C 7890 MSD 30 m X 0.25 mm id X 0.25 um HP-5MS GC Group/Presentation Title Agilent Restricted Month ##, 200X Milk Extrac

  12. Slide 12: LTM (Low Thermal Mass) Technology

    5/3/2010 “LTM” (Low Thermal Mass) Technology (Patented) Directly heat/cool fused silica GC columns Group/Presentation Title Agilent Restricted Month ##, 200X “LTM” (Low Thermal Mass) Technology •Direct heating of fused silica GC columns 12

  13. Slide 13: LTM Heating Speeds

    5/3/2010 Interfacing LTM GC to an Agilent 7890 or 6890 GC GC oven door replaced with LTM-ready GC oven door (easy) Use same GC injectors, detectors, autosamplers, software, … Column Modules mount outside isothermal GC oven for fast heating and cooling Independent and simultaneous temperature program

  14. Slide 14: Some Practical Uses of LTM Rapid Heating/Cooling

    5/3/2010 Typical Cooling Times for a LTM Column (Standard Size) Column Length o C 2m 5m 10 m 15 m 30 m 350->300 3 5 6 7 9 300->250 3 5 7 7 13 250->200 4 7 8 10 17 200->150 4 8 11 13 22 150->100 7 13 17 19 36 100->50 13 27 34 41 75 Type Time 350oC 50C LTM (2m Column) 34 seconds (= 3+3+4+4+7+13) Equil

  15. Slide 15: 9x Faster Heating/Cooling Cycle Times

    5/3/2010 Developing Faster GC Run Times for TPH Analysis (C10C44 Standard Shown) pA 10oC/min n-C10 Standard n-C14 100 30m Column - 7890 n-C23 80 GC Run n-C12 n-C16 n-C18 n-C20 n-C36 n-C22 n-C24 n-C26 n-C30 n-C28 n-C32 60 n-C40 n-C44 40 Time 20 0 pA 5 10 n-C14 15 20 25 30 35 min n-C10 n-C23 120 20oC/

  16. Slide 16: Soil Sample by TPH Analysis using LTM/7890

    5/3/2010 Soil Sample by TPH Analysis using LTM/7890 Reliable Calculated Results, <3 minute run time Concentration* Original Method (30 m) 1097 µg/mL 2X Method (15 m) 920 µg/mL LTM Method (5 m) 909 µg/mL *Calculated by Area Sum and Peak Grouping Group/Presentation Title Agilent Restricted Month ##, 2

  17. Slide 17: LTM System Technology - Summary

    5/3/2010 LTM System Technology - Summary • High efficiency temperature programming fast heating fast cooling (< 1 min in some configurations) high throughput fast method development • High performance chromatography utilize commercially available columns (up to 30m length) very good retention time r

  18. Slide 18: High Performance Triple-Axis Detector, Agilent 7000 GC/MS/MS

    5/3/2010 High Performance Triple-Axis Detector Ultra low neutrals noise Offset shield for steering rod secondary Z Long life and high linearity hyperbolic quartz particles transmission high energy “Gain Normalization” quadrupole analyzer dynode corrects tune file for detector aging to allow repeatab

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