Penumbra, Inc. · NYSE:PEN

Penumbra — 42nd Annual J.P. Morgan Healthcare Conference (January 2024)

19 slides from Penumbra's conference presentation, January 2024

1. Slide 1: Penumbra, Inc.

   Penumbra, Inc. 42nd Annual J.P. Morgan Healthcare Conference Copyright ©2024 Penumbra, Inc. All rights reserved.

2. Slide 2: Safe Harbor

   42nd Annual J.P. Morgan Healthcare Conference Safe Harbor SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS Except for historical information, certain statements in this presentation and oral statements accompanying this presentation are forw ard-looking in nature and are subject to risks, uncertain

3. Slide 3: Our Company

   42nd Annual J.P. Morgan Healthcare Conference Our Company ~4,000 Products Available Employees in 100+ Markets Headquartered in Alameda Products 2023 Revenue Guidance Manufactured in CA $1.05B–$1.07B (+24% to 26% YOY) Strong Profitability Copyright ©2024 Penumbra, Inc. All rights reserved. 3

4. Slide 4: Embolization & Access, Thrombectomy, Immersive Healthcare

   42nd Annual J.P. Morgan Healthcare Conference EMBOLIZATION & ACCESS THROMBECTOMY Computer-Assisted Vacuum Thrombectomy (CAVT) IMMERSIVE HEALTHCARE Copyright ©2024 Penumbra, Inc. All rights reserved. 4

5. Slide 5: Deep Dive on Thrombectomy

   Stroke Coronary PE Deep Dive on Thrombectomy DVT Arterial Copyright ©2024 Penumbra, Inc. All rights reserved. 5

6. Slide 6: CAVT – Second Generation Thrombectomy Technology

   42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology LIGHTNING FLASH LIGHTNING BOLT 7 THUNDERBOLT Copyright ©2024 Penumbra, Inc. All rights reserved. 6

7. Slide 7: CAVT – Second Generation Thrombectomy Technology (Lightning Flash, DVT)

   42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology LIGHTNING FLASH DVT Copyright ©2024 Penumbra, Inc. All rights reserved. 7

8. Slide 8: CAVT – Second Generation Thrombectomy Technology (Lightning Flash, PE)

   42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology LIGHTNING FLASH PE Copyright ©2024 Penumbra, Inc. All rights reserved. 8

9. Slide 9: CAVT – Lightning Bolt 7, Arterial

   42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology LIGHTNING BOLT 7 Arterial Pre 1st Pass 2nd Pass 3rd pass AT Bolt unable to reach Post Pop and PT Peroneal beyond this point due to length. Bolt was turned on just to see what would happen Copyright ©2024 P

10. Slide 10: CAVT – Thunderbolt, Stroke

    42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology THUNDERBOLT Stroke Copyright ©2024 Penumbra, Inc. All rights reserved. 10

11. Slide 11: CAVT – Second Generation Thrombectomy Technology

    42nd Annual J.P. Morgan Healthcare Conference CAVT – Second Generation Thrombectomy Technology LIGHTNING FLASH LIGHTNING BOLT 7 THUNDERBOLT Copyright ©2024 Penumbra, Inc. All rights reserved. 11

12. Slide 12: Stroke

    42nd Annual J.P. Morgan Healthcare Conference Stroke 30% 28 other catheters 57% MT Penetration Penumbra System 70% a Mechanical Thrombectomy (MT) Total Number of Annual U.S. Patients b 200,000 Sources are listed on slide 2. Copyright ©2024 Penumbra, Inc. All rights reserved. 12

13. Slide 13: Coronary

    42nd Annual J.P. Morgan Healthcare Conference Coronary 21% MT Penetration 5 manual 44% aspiration Indigo System catheters 79% c Mechanical Thrombectomy (MT) Total Number of Annual U.S. Patients d 289,000 Sources are listed on slide 2. Copyright ©2024 Penumbra, Inc. All rights reserved. 13

14. Slide 14: PE

    42nd Annual J.P. Morgan Healthcare Conference PE 11% MT Penetration 20% Indigo System 11 other devices 89% e Mechanical Thrombectomy (MT) Total Number of Annual U.S. Patients f 157,000 Sources are listed on slide 2. Copyright ©2024 Penumbra, Inc. All rights reserved. 14

15. Slide 15: DVT

    42nd Annual J.P. Morgan Healthcare Conference DVT 9% MT Penetration 9 other 46% devices Indigo System 91% g Mechanical Thrombectomy (MT) Total Number of Annual U.S. Patients h 351,000 Sources are listed on slide 2. Copyright ©2024 Penumbra, Inc. All rights reserved. 15

16. Slide 16: Arterial

    42nd Annual J.P. Morgan Healthcare Conference Arterial 11% MT Penetration 12 other devices 75% 89% Indigo System i Mechanical Thrombectomy (MT) Total Number of Annual U.S. Patients j 259,000 Sources are listed on slide 2. Copyright ©2024 Penumbra, Inc. All rights reserved. 16

17. Slide 17: Focused Areas of Work to Increase Number of Patients Treated

    42nd Annual J.P. Morgan Healthcare Conference Focused Areas of Work to Increase Number of Patients Treated INNOVATION COMMERCIAL MARKET ACCESS Evolved US vascular Initiate market access 4 new CAVT products commercial team to be able program in DVT, stroke, within next 16 months to take on increased

18. Slide 18: World's Leader in Mechanical Thrombectomy

    World's Leader in Mechanical Thrombectomy Head-to-Toe Copyright ©2024 Penumbra, Inc. All rights reserved. 18

19. Slide 19: Thank you

    Thank you Copyright ©2024 Penumbra, Inc. All rights reserved.

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