Inspiremd Inc. · NASDAQ:NSPR
Inspiremd — Investor Presentation (September 2025)
28 slides from Inspiremd's investor presentation, September 2025
Slide 1: InspireMD Poised to Revolutionize the Carotid Intervention Market
InspireMD Poised to Revolutionize the Carotid Intervention Market Nasdaq: NSPR
Slide 2: Disclaimers
Disclaimers Forward Looking Statement This presentation contains "forward-looking statements." Such statements may be preceded by the words "intends," "may," "will," "plans," "expects," "anticipates," "projects," "predicts," "estimates," "aims," "believes," "hopes," "potential" or similar words. For
Slide 3: Developer of CGuard Prime Carotid Stent Platform
Developer of CGuard® Prime Carotid Stent Platform Dedicated to advancing the prevention of stroke and treatment of carotid artery disease 3
Slide 4: Now Approved in the U.S. CGuard Prime Carotid Stent System
Now Approved in the U.S. CGuard® Prime Carotid Stent System Ongoing U.S. Commercial Launch, With a Trained and Seasoned Salesforce at the Ready A New Level of Stroke Prevention is Here ▪ With 60,000+ patients treated worldwide, we’re ready to elevate embolic prevention for U.S. physicians and their
Slide 5: Transforming the Carotid Intervention Market
Transforming the Carotid Intervention Market CGuard®Carotid Stent Platform CMS Coverage Expanded Proprietary MicroNet Technology Standard Risk and Asymptomatic Reimbursement Highly differentiated platform for treatment of Enables stent-first approach to carotid carotid artery disease and stroke prev
Slide 6: Endovascular Revolution Has Arrived
Endovascular Revolution Has Arrived MicroNetTM covered CGuard® stent platform could become the new gold standard CEREBRAL CORONARY THORACIC/ABDOMINAL PERIPHERAL CAROTID ARTERY ANEURYSMS ARTERY DISEASE AORTIC ANEURYSMS ARTERIAL DISEASE DISEASE5 AWAITING CONVERSION TO ENDO 30% Surgical1 23% Surgical2
Slide 7: $8B Global Market Potential
$8B Global Market Potential ~2.8 million People diagnosed with High Grade Carotid CURRENT UNTREATED GLOBAL MARKET Stenosis (HGCS) $8.0 Billion ~400,000 Global procedures (CEA/CAS/TCAR) annually to treat HGCS (1) ~155,000 CURRENT TREATED US Procedures (CEA/CAS/TCAR) GLOBAL MARKET annually $1.3 Billio
Slide 8: Carotid Stenting (CAS + TCAR) is on the Rise
Carotid Stenting (CAS + TCAR) is on the Rise CE CS ▪ DRG/CPT data by Facility and HCP 30,000 25,000 ▪ Trailing 12 Quarters through Q4 20,000 2024 (one quarter in arrears) 15,000 ▪ ~147K annual carotid intervention 10,000 CAS coverage claims TCAR coverage expansion 5,000 expansion ▪ Represents ~90% o
Slide 9: Market Shift
Market Shift The market has already begun the shift from surgery to stents (procedures and revenue opportunity) 30,000 $210M 2024 30,000 $80M 95,000 40,000 $280M 2027 40,000 $110M 75,000 60,000 $420M 2030 60,000 $160M 45,000 CAS TCAR CEA 9
Slide 10: The CGuard Difference: The Impact of MicroNet Technology
The CGuard® Difference: The Impact of MicroNetTM Technology1 Approximately 2/3 of neurovascular events (stroke, TIA) occur after carotid interventions take place2. Prevention depends on the protection from the stent implanted VS. MicroNet: Advanced Protection Technology MicroNet captures and locks t
Slide 11: Long-Term Stent Performance is the Cornerstone of Our Business
Long-Term Stent Performance is the Cornerstone of Our Business Benefits are independent of access method We are positioned to CGuard Prime CAS Tandem capitalize on the ongoing Stroke Transfemoral/ paradigm shift toward a Transradial “stent first” approach and away from surgery CGuard® Prime Tandem T
Slide 12: Scientific Advisory Board (Multidisciplinary KOLs)
Scientific Advisory Board (Multidisciplinary KOLs) Sean Lyden, M.D. Chris Metzger, M.D. Kenneth Rosenfield, M.D. Adnan H. Siddiqui, M.D., Ph.D. Vascular Surgeon Medical Director Interventional Cardiologist Professor, Vice Chairman of Cardiologist the Department of Neurosurgery 12
Slide 13: Unmatched Foundational Data and Evidence
Unmatched Foundational Data and Evidence 13
Slide 14: PMA Trial Design (C-GUARDIANS)
PMA Trial Design (C-GUARDIANS) Prospective, multicenter international single-arm clinical trial Pivotal Study Objective Evaluate the safety and efficacy of the CGuard® Carotid Stent System in the treatment of carotid Primary Endpoints artery stenosis Composite of DSMI through 30 days or ipsilateral
Slide 15: C-GUARDIANS: 30-Day Safety Outcomes
C-GUARDIANS: 30-Day Safety Outcomes 30-Day Death/Stroke/MI (DSMI) rates, compared to other carotid trials CGUARDIANS 30-day outcomes 30-day DSMI (multiple FDA trials) Intention to Treat Per Protocol1,2 8.30% 30-day DSMI 0.95% (3) 0.63% (2) 5.80% 5.40% 5.20% 5.10% 4.80% Death 0.32% (1) 0.0% (0) 3.50%
Slide 16: C-GUARDIANS: 1 Year Outcomes
C-GUARDIANS: 1 Year Outcomes 365-Day Death/Stroke/MI (DSMI) rates, compared to other carotid trials CGUARDIANS 365-day 365-day (multiple FDA trials) Intention to Treat Per Protocol1,2 12.20% 9.60% Primary Endpoint: 30-day 8.90% Death, Stroke, or MI + 1.93% (6) 1.70% (5) Ipsilateral Stroke between 7.
Slide 17: OUS Clinical Data Supporting CGuard Periprocedural Safety
OUS Clinical Data Supporting CGuard® Periprocedural Safety CGuard commercially available in Europe since 2015 (CE Mark) Study Year N DS 30-Day % (n) DSMI 30-Day % (n) CARENET 2015 30 0.0%(0) 0.0%(0) PARADIGM 2016 101 0.0%(0) 0.0%(0) CASANA 2017 82 1.22%(1) 1.22%(1) WISSGOTT I 2017 30 0.0%(0) 0.0%(0)
Slide 18: TCAR
TCAR INSPIREMOD
Slide 19: Transcarotid Arterial Revascularization (TCAR): Direct Carotid Access with Reverse Flow
Transcarotid Arterial Revascularization (TCAR): Direct Carotid Access with Reverse Flow InspireMD Combines SwitchGuard NPS with Best-in-Class CGuard® Implant 1. Transient flow reversal combined with sustained embolic prevention in transcervical revascularization of symptomatic and highly-emboligenic
Slide 20: Developing Comprehensive TCAR Solution
Developing Comprehensive TCAR Solution 80cm TCAR Market Opportunity ~3,000 TCAR-trained physicians in the U.S. 1 ~30,000 TCAR procedures (~$210M) performed in the U.S. in 2024, double-digit growth projected 1,2 1 Piper-Sandler model, 05/01/24 2 Piper-Sandler model, 05/01/24 20
Slide 21: Commercial and Corporate
Commercial and Corporate INSPIREMOD
Slide 22: Commercial Footprint
• Active selling in more than 30 countries Commercial Footprint • Over 65,000 systems sold • Average CAS Market share of 25% Signed agreement with Chinese distributor. Working toward distribution FDA PMA approval received in June 2025 Exploring expansion opportunities Taiwan, Japan, and Korea Curren
Slide 23: Commercial Traction Progress in the U.S.
Commercial Traction Progress in the U.S. Salesforce Targeting Demand High powered 20+person U.S. commercial Leverage claims database to: Strong physician interest paired with a team with CAS, TCAR, and Neurovascular • Map carotid stent procedures to the seasoned field team have driven significant ex
Slide 24: Marketing
Marketing Q2 Launch Activities and Collateral “ I'm happy to announce [CGuard® Prime] is now commercially available for use in our labs and I suggest that this is a complete paradigm shift in carotid stenting because of these extraordinary low event rates. ~David Fiorella, MD, PhD Stony Brook Univer
Slide 25: Roadmap / Milestones
Roadmap / Milestones Key Value Drivers 2025 2026 2027 CGuard® Prime CAS Approval CGuard Prime CAS Market Expansion SwitchGuard NPS Clearance / Launch (Full Launch for CAS TCAR Tool Kit) CGuard Prime indicated stent with U.S Operational Expansion CGuard Prime TCAR Approval Build out of U.S. HQ, Opera
Slide 26: Robust Intellectual Property Portfolio
Robust Intellectual Property Portfolio Proprietary platform technology supported by IP Patent Rights Issued Pending USA 20 7 Rest of World 54 21 InspireMD will continue to strengthen and broaden its patent protection globally to enable future pipeline products IP Counsel: Kligler and Associates, P.A
Slide 27: Transformational July 2025 PIPE and May 2023 Financing Up To $153.7 Million
Transformational July 2025 PIPE and May 2023 Financing Up To $153.7 Million To advance the company towards successful U.S. commercialization and path to profitability Strong validation from leading July 2025 PIPE Financing of $40.1 million fundamental healthcare investors, with additional participat
Slide 28: Nasdaq: NSPR
NASDAQ Nasdaq: = NSPR NSPR