Galectin Therapeutics Inc. · NASDAQ:GALT
Galectin Therapeutics — Investor Presentation (March 2013)
35 slides from Galectin Therapeutics's investor presentation, Mar 11, 2013
Slide 1: Galectin Therapeutics Corporate Summary
Exhibit 99.1 Galectin Corporate March NASDAQ: www.galectintherapeutics.com 11, Therapeutics 2013 Summary GALT
Slide 2: Forward Looking Statements
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Slide 3: What Galectin Therapeutics Does
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Slide 4: Investment Highlights
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Slide 5: Key Corporate Facts
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Slide 6: Science, Liver Fibrosis, Cancer Therapy
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Slide 7: Galectins Are Critical Participants in Disease Pathogenesis
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Slide 8: Galectin Inhibitors as a Class of Pathology Modulators
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Slide 9: Regulatory Status
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Slide 10: Liver Fibrosis
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Slide 11: Galectin-3 Is a Critical Protein Target for Fibrosis Therapy
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Slide 12: NASH: No Approved Therapy, Multi-Billion Dollar Market
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Slide 13: GR-MD-02 Eliminated Fibrosis in a Mouse Model of NASH
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Slide 14: Treatment with GR-MD-02 Markedly Reduces Galectin-3 in NASH Mice
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Slide 15: GR-MD-02 Effectively Treats Toxin-Induced Liver Fibrosis in Rats
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Slide 16: Targeting Advanced Fibrosis in NASH
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Slide 17: GR-MD-02 NASH Clinical Development Program
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Slide 18: Galectin Competition in NASH
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Slide 19: Cancer Therapy
Science Galectin Liver Immune Mechanism Regulatory Competitive © 2013Fibrosis Galectin of Enhancement Therapeutics Function Inhibitors Galectins and of Positioning Action Clinical Therapeutics in Plan Cancer NASDAQ:GALT Therapy 19
Slide 20: Galectins Have Multiple Roles in Tumor Pathogenesis
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Slide 21: Tumors Evade the Immune System Using Galectin-3
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Slide 22: GM-CT-01 Phase 2a Melanoma Trial
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Slide 23: GM-CT-01 Cancer Development Program
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Slide 24: Enhancing Immune Function in Cancer Immunotherapy
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Slide 25: Key Company Milestones
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Slide 26: Investment Highlights
Galectin Investment Proprietary First Complex GR-MD-02: GM-CT-01: Validated Pre-clinical Large NASH Enhancing Intellectual Strong Sole No Experienced Management © 2013 licenses in ownership Market and patent class, Galectin Therapeutics carbohydrate Science liver the Property models Compounds Highli
Slide 27: Appendix
Galectin © Appendix 27 NASDAQ:GALT 2013 Galectin Therapeutics Therapeutics
Slide 28: Experienced Management Team
Galectin Experienced Peter in GlaxoSmithKline Harold Therapeutics Eliezer Koor Thomas PricewaterhouseCoopers, J. Over Solvay © 28 NASDAQ:GALT 2013 Rex liverBiotechnologies, 25 30 10 20 G. Horton disease H. Pharmaceuticals Pharmaceuticals, Zomer, Galectin A. years Therapeutics Traber, Shlevin, McGaul
Slide 29: Galectin Protein Structure
CONFIDENTIAL TYPE T 3 Carbohydrate Galactose-containing One-CRD Galectines-3 Two-CRD cell–cell cell–matrix lattice outside Inside signal Galectin © 29 NASDAQ:GALT wo-CRD 2013STRUCTURE formation transduction cell cell Galectin and Therapeutics Proteins proteins 4,6,8,9,12 galectins 1,2,5,7,10,11,13,1
Slide 30: Rationale for Targeting Galectin Proteins with Complex Carbohydrates
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Slide 31: Intellectual Property
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Slide 32: Galectin Inhibition Mechanisms in NASH
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Slide 33: General Approaches to Treating NASH
Galectins General Treat Obesity Lipid Modulate Protease Bile Anti-Oxidant Anti-collagen Lifestyle, Examples Aramchol Pioglitazone EGS21 GS-9450 Pentoxifylline Obeticolic Colesevelam Vitamin MND-21 Lysyl Cysteamine Can Comments Failed Cholesterol Abandoned Non Liver Intestinal FXR Effective Omega-3 P
Slide 34: Other Galectin Companies
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Slide 35: Capitalization
Galectin Capitalization Shares Common Preferred Preferred: Warrants: *Options ** *** © Total Management, 10X Series Other Publicly Public Exercise 2013 Weighted Weighted Fund Outstanding Warrants** Warrants Float A C(9/30/12) Galectin Traded Outstanding*** Therapeutics Shares Shares Stock Shares Ser
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