Tempus Ai, Inc. · NASDAQ:TEM
Tempus Ai — Technical Presentation (2023)
7 slides from Tempus Ai's technical presentation, 2023
Slide 1: Index of Suspicion: Predictors of Tricuspid Regurgitation Progression and Follow-up Echo Imaging
Index of Suspicion: Predictors of Tricuspid Regurgitation Progression and Follow-up Echo Imaging in An Artificial-intelligence Enhanced Study OMAR KHALIQUE, MD, FACC, FASE, FSCCT, FSCMR, FSCAI DIRECTOR, DIVISION OF CARDIOVASCULAR IMAGING DIRECTOR, ADVANCED CARDIOVASCULAR IMAGING FELLOWSHIP SAINT FRA
Slide 2: Background
Background ► Tricuspid regurgitation (TR) is associated with negative outcomes. ► There are few data on factors influencing TR progression and patient follow-up after TR is discovered.
Slide 3: Methods
Methods ► A retrospective cohort study of patients with less than severe TR was conducted from August 2018 to December 2021 to identify predictors of 1) disease progression to severe TR, and 2) presence of follow up echo. ► Patients were followed up from their first (index) echo with TR up until Jun
Slide 4: Results
Results ► 33,108 patients with TR (27,107 mild, 2,517 mild-moderate, 2,851 moderate, 633 moderate-severe) were included in the study (min / max / average observation times: 521 / 1,769 / 1,060 days). ► 10,696 (32%) had a follow up echo that allowed us to assess disease progression (average time to f
Slide 5: Predictors of Disease Progression
Predictors of Disease Progression ► Progression to severe TR was dependent on the index TR severity (0.3% mild; 1.9% mild-moderate; 4.2% moderate; 10% moderate-severe). ► However, when controlling for index TR severity, RVSP, RAP, and age, females had a 1.6x (95% CI HR 1.21-2.09) higher risk of prog
Slide 6: Predictors of Follow-up Echo
Predictors of Follow-up Echo ► When controlling for other variables, an increased severity at index did not result in higher odds of a follow-up echo (moderate-severe vs mild TR, OR=1.03, p=0.78) ► Females were 20% less likely to receive a follow up echo (95% CI OR 0.78-0.89). ► LVEF ≤ 35% (95% CI O
Slide 7: Conclusions
Conclusions ► These findings highlight the importance of comprehensive risk assessment. ► These findings raise concerns about under-recognition of the importance of TR follow-up and potential sex disparities in TR management and follow-up.