Context Therapeutics Inc. · NASDAQ:CNTX
Context Therapeutics — Investor Presentation (September 2022)
25 slides from Context Therapeutics's investor presentation, Sep 27, 2022
Slide 1: Corporate Presentation: Advancing Medicines for Female Cancers
September 2022 Corporate Presentation Advancing Medicines for Female Cancers
Slide 2: Forward Looking Statement
Forward Looking Statement Except for statements of historical fact, any information contained in this presentation may be a forward-looking statement that reflects the Company’s current views about future events and are subject to risks, uncertainties, assumptions and changes in circumstances that m
Slide 3: Context Therapeutics Overview: Executive Summary
Context Therapeutics Overview Context Therapeutics Inc. - Sept. 20223 Executive Summary Focus on Women’s Oncology → Unmet clinical need in breast, ovarian, and endometrial cancers ONA-XR oral PR antagonist → ONA-XR is novel, potentially first-in-class progesterone receptor (PR) antagonist → Q4 2022
Slide 4: Pipeline Executive Summary
Pipeline Executive Summary (1) Tyligand Biosciences Ltd licensed rights to ONA-XR in China, HK, Macau * Investigator Sponsored Trial Cancer Clinical Indication Research Phase 1 Phase 2 Phase 3 Key Anticipated Milestones FDA Fast Track ONA-XR (PR antagonist)1 Breast Cancer 2L/3L ER+,PR+,HER2- Combina
Slide 5: ONA-XR Progesterone Receptor Antagonist
ONA-XR Progesterone Receptor Antagonist 5 Context Therapeutics Inc. - Sept. 2022
Slide 6: Onapristone Extended Release (ONA-XR)
Onapristone Extended Release (ONA-XR) Context Therapeutics Inc. - Sept. 20226 ONA-XR Mechanism of Action → Onapristone is a progesterone receptor (PR) antagonist that suppresses PR oncogenic signaling → PR oncogenic signaling is associated with breast, ovarian, and endometrial cancer → Onapristone i
Slide 7: Clinical Development Strategy
Clinical Development Strategy Blocking cancer growth by combining antiestrogen and antiprogestin therapies Context Therapeutics Inc. - Sept. 20227 ONA-XR Cell Survival Stemness Immune EvasionProliferation Estrogen Progesterone Cancer Driver Stimulus Cancer Growth and MetastasisOutcome Antiestrogens
Slide 8: ONA-XR Evaluation in Breast Cancer Clinical Trials
ONA-XR Evaluation in Breast Cancer Clinical Trials 8 Context Therapeutics Inc. - Sept. 2022 Breast Cancer Treatment Line Context Trial Design Clinical Collaborator Treatment Trial Status PR+ Patients (US)1 Medical Need Adjuvant (after primary disease treatment) Window of Opportunity ONA-XR Completed
Slide 9: ONA-XR Evaluation in Gynecologic Clinical Trials
ONA-XR Evaluation in Gynecologic Clinical Trials 9 Context Therapeutics Inc. - Sept. 2022 Cancer Context Trial Design Clinical Collaborator Trial Status PR+ Patients (US)1 Standard of Care (SOC) Medical Need Recurrent Endometrial Combination with anastrozole in PR+ patients Enrolling Patients ~25k L
Slide 10: Elacestrant + ONA-XR Combination Clinical Trial
Elacestrant + ONA-XR Combination Clinical Trial Clinical Trial Collaboration with Menarini 10 Context Therapeutics Inc. - Sept. 2022
Slide 11: Rationale for Clinical Trial Collaboration
Rationale for Clinical Trial Collaboration • Elacestrant is the first oral SERD to show positive Ph 3 top line results1 • Priority Review and assigned a PDUFA date of February 17, 2023 • Potential to enhance elacestrant clinical activity in metastatic breast cancer • Establish clinical proof of conc
Slide 12: Phase 1b/2 ELONA Trial Design
Phase 1b/2 (ELONA Trial) – Designed to Evaluate Combination Efficacy and Tolerability • Indication: ER+,PR+,HER2- advanced or metastatic breast cancer • Study: Phase 1b (n=12-28) / Phase 2 (n=45) • Primary Endpoint: overall response rate (ORR) • Secondary Endpoint: progression free survival (PFS), c
Slide 13: CLDN6xCD3 Bispecific Antibody Program
CLDN6xCD3 Bispecific Antibody Program 13 Context Therapeutics Inc. - Sept. 2022
Slide 14: Claudin (CLDN) Proteins
Claudin (CLDN) Proteins • Tight junctions (TJ) regulate cell barrier and permeability • CLDN proteins constitute a structural core of TJ, along with junction adhesion molecule (JAM) and occludin • Over 20 CLDN proteins have been characterized • Dysregulation of CLDN protein expression and function o
Slide 15: Many CLDN Proteins are Associated with Disease
Many CLDN Proteins are Associated with Disease CLDN6xCD3 Bispecific Antibody Program Context Therapeutics Inc. - Sept. 202215 Human CLDN Family Tree CLDN6 shares significant homology with CLDN3, 4, 9 CLDN Disease Reference CLDN 1 Colitis, skin permeability Bhat 2016, Furuse 2001 CLDN 2 Colorectal ca
Slide 16: CLDN6 is an Emerging Oncology Target
CLDN6 is an Emerging Oncology Target CLDN6xCD3 Bispecific Antibody Program Context Therapeutics Inc. - Sept. 202216 CLDN6 is a tumor-specific protein that is present at high surface density across adult and pediatric cancers1 CLDN6 selectivity is required to avoid off-target liabilities identified i
Slide 17: CLDN6 Prevalence in Cancer
CLDN6 Prevalence in Cancer CLDN6xCD3 Bispecific Antibody Program Context Therapeutics Inc. - Sept. 202217 Cancer Prevalence (IHC, RNAseq) Reference Testicular 95% Reinhard 2020 Ovarian 54-55% Reinhard 2020, Wang 2013 Gastric 13-55% Gao 2013, Kohmoto 2020, Lin 2013 NSCLC 6.5-50% Micke 2014, Reinhard
Slide 18: CLDN6xCD3 Bispecific Antibody Program
CLDN6xCD3 Bispecific Antibody Program Context Therapeutics Inc. - Sept. 202218 CLDN6xCD3 Bispecific Antibody Program We have developed a library of CLDN6xCD3 bispecifics • Explored a range of bispecific frameworks, CLDN6 sequences, and CD3 sequences • Comparator bispecifics generated for benchmarkin
Slide 19: Our Antibodies Display High Selectivity for CLDN6
Our Antibodies Display High Selectivity for CLDN6 CLDN6xCD3 Bispecific Antibody Program Context Therapeutics Inc. - Sept. 202219 Benchmark = IMAB027 Rucker et al., Development of CLDN6 bispecific antibodies for treatment of ovarian cancer, AACR 2022 Key Takeaways • Benchmark (IMAB027) exhibits off-t
Slide 20: CLDN6xCD3 Bispecific Antibody Library
CLDN6xCD3 Bispecific Antibody Library CLDN6xCD3 Bispecific Antibody Program Bispecific antibodies retain high CLDN6 specificity T-cell Dependent CytotoxicityCLDN9 Reactivity Bispecifics induce robust T-cell dependent cytotoxicity Rucker et al., Development of CLDN6 bispecific antibodies for treatmen
Slide 21: Corporate
Corporate 21 Context Therapeutics Inc. - Sept. 2022
Slide 22: Experienced Leadership Team
Context Therapeutics Inc. - Sept. 202222 Corporate Experienced Leadership Team • Experienced team with deep oncology experience • Our CMO led the clinical development of multiple blockbuster drugs for female cancers, including Kisqali, Arimidex, and Afinitor • Our management team is supported by a B
Slide 23: Recent and Key Anticipated Milestones
Recent and Key Anticipated Milestones ONA-XR 1H 2022 2H 2022 2023 2024 Breast – AACR preclinical update Breast – ELONA trial initiation Breast – ELONA trial Phase 1b data Breast – 2L/3L (post-CDK4/6) Phase 2 preliminary data Endometrial – Phase 2 preliminary data Granulosa Cell – Phase 2 preliminary
Slide 24: Corporate Investment Highlights
Corporate Investment Highlights Female Cancers Large Unmet Need Progesterone Receptor and Claudin 6 High-Value Targets Multiple Data Readouts in Q4 2022 Near-Term Milestones Deep Domain Experience, Track Record of Success Strong Team Expected Cash Runway into Q1 2024 Financial Strength Context Thera
Slide 25: Bringing Change for Female Cancers
BRINGING CHANGE FOR FEMALE CANCERS © CONTEXT THERAPEUTICS 2022
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