Exelixis, Inc. · NASDAQ:EXEL

Exelixis — Proxy Contest (May 2023)

74 slides from Exelixis's proxy contest presentation, May 11, 2023

  1. Slide 1: More Change Is Needed at Exelixis

    INVESTOR PRESENTATION MORE CHANGE IS NEEDED AT EXELIXIS MAY 2023

  2. Slide 2: Table of Contents

    FARALLON | Table of Contents I Executive Summary 3 II Exelixis Has Underperformed and Has Lost Credibility with Investors and Analysts 8 III Exelixis ’ Underperformance Is Due to Poor Decisions by the Board and Management 21 IV Further Board Refreshment Is Necessary to Drive Change 42 V Farallon’s P

  3. Slide 3: Executive Summary

    INVESTOR PRESENTATION Executive Summary

  4. Slide 4: Executive Summary

    FARALLON | Executive Summary 4 ▪ Exelixis has many fundamental strengths: – Good commercial operations – Strong cash flow from cabozantinib – High probability of cabozantinib patent coverage to 2030 – Cabozantinib is a valuable, life - extending therapy for patients suffering from RCC and HCC – Poss

  5. Slide 5: About Exelixis, Inc.

    FARALLON | About Exelixis , Inc. (Nasdaq: EXEL) 5 Five - Year Total Shareholder Return 1 Company Overview 2 ▪ Exelixis is a biotechnology company focused on the discovery, development and commercialization of cancer drugs ▪ Exelixis targets a broad range of cancer types and indications using a varie

  6. Slide 6: About Farallon Capital

    FARALLON | About Farallon Capital 6 Overview ▪ Established in 1986 ; 37 years of investment experience and performance ▪ Six offices globally. Based in San Francisco ▪ $36 billion of capital under management ▪ 2 90+ employees . Experienced senior team with 17 - year average tenure at the Firm ▪ Inve

  7. Slide 7: Shareholders Should Support Farallon's Nominees

    FARALLON | Shareholders Should Support Farallon’s Nominees 7 Exelixis ’ Board has not created value We believe our Nominees will drive positive change – Exelixis has underperformed its peers and the applicable indices over most relevant time periods, and the Company is significantly undervalued – In

  8. Slide 8: Exelixis Has Underperformed and Has Lost Credibility with Investors and Analysts

    INVESTOR PRESENTATION Exelixis has Underperformed and has Lost Credibility with Investors and Analysts

  9. Slide 9: Exelixis' Performance Over Recent Time Periods Has Been Disappointing

    FARALLON | Exelixis’ Performance Over Recent Time Periods Has Been Disappointing… 9 1 - Year Total Shareholder Return 1 3 - Year Total Shareholder Return 1 5 - Year Total Shareholder Return 1 1. Source: FactSet and Bloomberg. Data as of March 17, 2023, the last trading day before Farallon filed its

  10. Slide 10: And The Company's Long-Term Performance Is Even Worse

    FARALLON | … And The Company’s Long - Term Performance Is Even Worse 10 15 - Year Total Shareholder Return 1 20 - Year Total Shareholder Return 1 Total Shareholder Return Since IPO 1 1. Source: FactSet and Bloomberg. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule

  11. Slide 11: Exelixis Has Created Little Value for Shareholders as a Public Company

    FARALLON | Exelixis Has Created Little Value for Shareholders as a Public Company 11 1. Source: Bloomberg. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D with the SEC. (200%) (100%) 0% 100% 200% 300% 400% 500% 600% 700% 800% 2000 2005 2010 2015 2020 TOTAL SHAR

  12. Slide 12: Exelixis' Claim That TSR Was Impacted by Headwinds Is Disingenuous

    FARALLON | We Believe Exelixis ’ Claim that its TSR Has Been Impacted By “Headwinds” Is Disingenuous 12 1. Source: Exelixis Letter to Shareholders, filed with the SEC on May 1, 2023. 2. Source: Bloomberg. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D with the

  13. Slide 13: The Company's Challenges Have Been Largely Self-Inflicted

    FARALLON | The Company’s Challenges Have Been Largely Self - Inflicted 13 1. Source: FactSet, Bloomberg and Company filings. (0.2%) 0.1% (2.4%) (4.5%) 1.3% (2.0%) (7.4%) (6.3%) 0.4% (1.9%) CONTACT-03 Press Release Q4 2022 Earnings Q4 2022 Preliminary Results at JPM Conference CONTACT-01 Press Releas

  14. Slide 14: Exelixis Has Failed to Deliver Value During Tenures of Most Directors

    FARALLON | Exelixis Has Failed to Deliver Value During The Tenures of Most Directors 14 1. Source: FactSet and Company filings. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D w ith the SEC. 2. Source: FactSet and Company filings. Data as of April 25, 2023. NET

  15. Slide 15: Exelixis Is Significantly Undervalued Relative to Peers

    FARALLON | Exelixis Is Significantly Undervalued Relative to Peers… 15 EV/REVENUE MULTIPLES 1 1. Source: FactSet. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D with the SEC. “Proxy Pee rs” include ACADIA Pharmaceuticals, Alkermes, Alnylam Pharmaceuticals, Bei

  16. Slide 16: And the Valuation Discount Has Been Persistent

    FARALLON | …And the Valuation Discount Has Been Persistent 16 1. Source: FactSet. Data runs from March 17, 2020 to March 17, 2023, the last trading day before Farallon filed its Schedule 13D wi th the SEC. “Proxy Peers” include ACADIA Pharmaceuticals, Alkermes, Alnylam Pharmaceuticals, BeiGene , Bio

  17. Slide 17: Sell-Side Analysts Have Become Increasingly Negative

    FARALLON | Sell - Side Analysts Have Become Increasingly Negative… 17 1. Source: FactSet. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D with the SEC. $32.72 $24.63 $4.89 $0.68 Mean Analyst Price Target 1 Mean FY 2023E EPS Estimate 1 Despite strong revenue and

  18. Slide 18: And Do Not Value Exelixis' Pipeline

    FARALLON | … And Do Not Value Exelixis’ Pipeline 18 [O]ur current base case for EXEL ($29 PT) assumes… no value assigned to Cabo label - expansion opportunities or the pipeline ” 2 R&D 3x over the last few years despite the ROIC re: the pipeline recently. Cutting the spend in half would add ~25% to

  19. Slide 19: Exelixis Has Been Abandoned by Active Managers

    FARALLON | Exelixis Has Been Abandoned by Active Managers 19 1. Source: FactSet. Data as of March 31, 2023. 2. “Big Three” Index Funds include BlackRock, State Street and Vanguard. 21.8% 8.7% 16.5% 24.8% Select Active Managers Total Big Three Index Funds Total 29.2% 27.5% 18.3% 8.5% 8.3% 6.9% 0.0% 5

  20. Slide 20: Exelixis Has Been Abandoned by Active Managers (Continued)

    FARALLON | 385% 130% 94% 87% 22% - 15% - 26% - 35% - 64% - 64% - 67% - 69% - 87% - 88% - 99% - 100% - 100% - 100% - 100% - 100% Median: - 66% Exelixis Has Been Abandoned by Active Managers (Continued) 20 1. Source: FactSet. Data as of March 31, 2023. CHANGE IN POSITION OF TOP 20 SHAREHOLDERS SINCE D

  21. Slide 21: Exelixis' Underperformance Is Due to Poor Decisions by the Board and Management

    INVESTOR PRESENTATION Exelixis ’ Underperformance is Due to Poor Decisions by the Board and Management

  22. Slide 22: Exelixis' Underperformance and Low Valuation Have Known Causes

    FARALLON | We Believe Exelixis ’ Underperformance and Low Valuation Have Known Causes 22 22 Inefficient and unfocused R&D ▪ Exelixis ’ R&D spending has increased significantly, but has not delivered strong returns ▪ Exelixis ’ pipeline appears unfocused, without a clear theme or unifying principle S

  23. Slide 23: R&D Spending Has Increased Significantly but Become Less Efficient

    FARALLON | R&D Spending has Increased Significantly but has Become Less Efficient 23 1. Source: FactSet and Company filings. ▪ Exelixis ’ most efficient use of capital occurred between 2017 and 2019, which led to highly profitable indication expansion in front - line metastatic renal cell carcinoma

  24. Slide 24: Exelixis' R&D Spend Is Increasing as Peers Show Restraint

    FARALLON | Exelixis ’ R&D Spend is Increasing as Peers are Showing Restraint… 24 1. Source: FactSet and Company filings. 2. Source: FactSet. Index data represents average of companies that have five years’ worth of data. 3. Source: Steven Aronowitz , Joachim Bleys , Edd Fleming, and Robert Hsiao, “T

  25. Slide 25: And Is Disproportionate to the Size and Value of the Company

    FARALLON | … And is Disproportionate to the Size and Value of the Company 25 1. Source: FactSet and company filings. “Proxy Peers” include ACADIA Pharmaceuticals, Alkermes, Alnylam Pharmaceuticals, BeiGene , BioMarin Pharmaceutical, Blueprint Medicines, Emergent BioSolutions, Horizon Therapeutics, I

  26. Slide 26: The Company's FY 2023E $1 Billion+ R&D Guidance Shocked the Street

    FARALLON | $867 $1,025 FY 2023 Street Consensus FY 2023 Guidance The Company’s FY 2023E $1 Billion+ R&D Guidance Shocked the Street 26 1. Source: FactSet and Company reports. +18% FY 2023 R&D Spend 1 1 Exelixis ’ FY 2023 guidance indicates a significant step - up in R&D expenses at a time when most

  27. Slide 27: Exelixis' Development Track Record Is Poor

    FARALLON | Exelixis ’ Development Track Record is Poor 27 Program in Development Favorable or Unfavorable Outcome Ph3 CONTACT - 01 (2L NSCLC) Failed to meet its OS primary endpoint Ph3 CONTACT - 03 Failed to meet its OS primary endpoint Ph1b COSMIC - 021 Cohort 6 (2L+ mCRPC ) Further cohort expansio

  28. Slide 28: Cabozantinib Trial Results and CONTACT Study Failures

    FARALLON | ▪ At ASCO 2020, Exelixis presented the results of a trial of cabozantinib in combination with atezolizumab to treat lung cancer for 30 patients. After 12.1 months it showed an Overall Response Rate (“ORR”) of 27% and a median Progression Free Survival (“mPFS”) of 4.2 months ▪ After the st

  29. Slide 29: Exelixis' Pipeline Strategy Appears Unfocused

    FARALLON | Exelixis’ Pipeline Strategy Appears Unfocused 29 ▪ At a time when most biotech companies are prioritizing their spend and allocating resources to higher - probability investments, Exelixis is moving in the opposite direction ▪ The Company has vastly more active trials than most of its pee

  30. Slide 30: Exelixis' Lack of Focus Is Getting Worse

    FARALLON | Exelixis’ Lack of Focus is Getting Worse 30 1. Source: FactSet and Company website. Partnership announcements are cumulative from CY 2018 to the end of CY 2022. 15 13 12 24 27 21 28 37 47 43 8 11 11 8 8 44 52 60 79 78 2018 2019 2020 2021 2022 Phase 1/Pre-Clinical Phase 2 Phase 3 Partnersh

  31. Slide 31: Exelixis' R&D Efforts Appear to Have Destroyed Value

    FARALLON | Exelixis’ R&D Efforts Appear to have Destroyed Value… 31 1. Source: FactSet and Company website. Partnership announcements are cumulative from CY 2018 to the end of CY 2022. ▪ Exelixis has spent over $2.6 billion on R&D over the last five years and has little to show for it ▪ In fact, the

  32. Slide 32: And the Market Is Assuming That Trend Will Continue

    FARALLON | $17.55 $33 Unaffected Stock Price Illustrative Fair Value … And the Market is Assuming that Trend Will Continue 32 1. Source: FactSet, Jefferies estimates and Farallon analysis. Model assumes cabo patent expires in 2030 and Exelixis offers a 1 0% price discount and maintains 75% market sh

  33. Slide 33: The Company's Cash Position Has Been Increasing Steadily

    FARALLON | The Company’s Cash Position Has Been Increasing Steadily… 33 1. Source: FactSet. “Cash, Cash Equivalents, Restricted Cash Equivalents & Investments” refers to gross figure due to capital le ase s. $457 $852 $1,389 $1,539 $1,857 $2,068 5% 14% 26% 25% 32% 40% 0% 5% 10% 15% 20% 25% 30% 35% 4

  34. Slide 34: To a Level That Appears Excessive, Even After Share Repurchases

    FARALLON | …To a Level that Appears Excessive, Even After Share Repurchases 34 ▪ The Company’s cash and securities portfolio is significantly greater than its peers ▪ While we applaud Exelixis for avoiding large value - destructive M&A, we believe the Company’s cash position is overly conservative ▪

  35. Slide 35: Exelixis Seems Unlikely to Deliver on Its Stated Target for Cabo

    FARALLON | $4.0 $2.3 Exelixis January 2020 Target Analyst Consensus Exelixis Seems Unlikely to Deliver on Its Stated Target for Cabo 35 ▪ At the 2020 JP Morgan Conference, Exelixis laid out a path to reaching $4 billion in net product revenue from Cabo by 2025 ▪ The market reacted positively to what

  36. Slide 36: CEO Compensation Is Not Aligned with Performance

    FARALLON | CEO Compensation Is Not Aligned with Performance 36 4 Total CEO Compensation 1 Market Cap Percentile & CEO Pay Percentile vs. Proxy Peers 1 1. Source: FactSet, Bloomberg and Company filings. Data as of April 30, 2022. Peer data refers to median. $5.1 $8.5 $16.9 $8.2 Exelixis Proxy Peers 2

  37. Slide 37: CEO Compensation Is Not Aligned with Performance (Continued)

    FARALLON | CEO Compensation is Not Aligned with Performance (Continued) 37 4 Annual Incentive Award 1 Long - Term Incentive Award 1 55% 60% 37% 120% 115% 100% 2020 2021 2022 Annual TSR Percentile % of Target Bonus Awarded 22% 29% 35% 100% 200% 100% 2018-2020 2019-2021 2020-2022 Three-Year TSR Percen

  38. Slide 38: The Company's Compensation Program Reflects Its Lack of Focus

    FARALLON | The Company’s Compensation Program Reflects its Lack of Focus 38 ▪ There are 14 different metrics in the Company’s annual incentive plan – Some of these metrics – progress on the construction of buildings, for example – have little connection to the Company’s core business and are largely

  39. Slide 39: Exelixis Has Delivered More Value for Insiders than for Shareholders

    FARALLON | Exelixis has Delivered More Value for Insiders than for Shareholders 39 CUMULATIVE COMPENSATION PAID TO DIRECTORS & EXECUTIVES VS. VALUE CREATED FOR SHAREHOLDERS 1 1. Source: FactSet, Bloomberg and Company filings. Value created defined as the change in Exelixis ’ stock price during each

  40. Slide 40: Exelixis' Company Culture Appears to Be Suboptimal

    FARALLON | Exelixis ’ Company Culture Appears to Be Suboptimal 40 1. Source: Glassdoor. Data as of April 20, 2023. Overall Glassdoor Rating 1 Recommend to a Friend 1 Approve of CEO 1 3.0 Proxy Peer Median: 3.8 HZNP SRPT BMRN INCY NBIX SGEN RARE UTHR SAGE ALKS ALNY BPMC IONS JAZZ ACAD NVCR BGNE EBS N

  41. Slide 41: Employees Are Seemingly Frustrated by Leadership

    FARALLON | Employees are Seemingly Frustrated by Leadership 41 “ Management with no plan on business operations has recently fired key contributors… People are miserable and it shows in every meeting and interaction.” 1 – Former Director, November 30, 2022 “ Reputation has suffered which has contrib

  42. Slide 42: Further Board Refreshment Is Necessary to Drive Change

    INVESTOR PRESENTATION Further Board Refreshment is Necessary to Drive Change

  43. Slide 43: We Believe Exelixis' Board Remains Stale

    FARALLON | We Believe Exelixis ’ Board Remains Stale 43 ▪ The Exelixis Board currently has the tenth - highest average tenure in the entire Nasdaq Biotechnology Index (N = 273) and one of the highest among the Company’s peers ▪ The Board’s long tenure is inconsistent with governance best practices a

  44. Slide 44: Board Leadership Is Concentrated Among the Longest-Tenured Directors

    FARALLON | Board Leadership is Concentrated Among the Longest - Tenured Directors 44 1. Source: FactSet and Company filings. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D w ith the SEC. 28.3 19.1 18.6 18.2 16.1 6.5 Board Chair Audit Committee Chair R&D Commit

  45. Slide 45: Exelixis' Directors Have Not Driven Value for Shareholders

    FARALLON | Exelixis ’ Directors Have Not Driven Value for Shareholders 45 1. Source: Bloomberg. Data as of March 17, 2023, the last trading day before Farallon filed its Schedule 13D with the SEC. * Not standing for reelection at the 2023 Annual Meeting. vs. Proxy Peers vs. Close Peers vs. Nasdaq Co

  46. Slide 46: Insiders Have Been Aggressively Selling Shares

    FARALLON | Insiders Have Been Aggressively Selling Shares 46 ▪ While Exelixis’ management promotes the success of cabozantinib and the promising pipeline of new drugs, the Board and CEO have been selling stock ▪ There is a clear inconsistency between the story that management is telling shareholders

  47. Slide 47: Insider Sales Reflect a Lack of Optimism and Alignment

    FARALLON | We Believe Insider Sales Reflect a Lack of Optimism and Alignment 47 Director Stock Ownership ($M) 1 Executive Stock Ownership ($M) 1,2 $115.5 $82.5 Value of Stock Sold Value of Stock Currently Owned $5.81 $15.29 $22.85 $20.72 $21.54 $22.29 $22.34 $19.90 $17.67 Current Average Analyst Pri

  48. Slide 48: Farallon's Proposal for Change

    INVESTOR PRESENTATION Farallon’s Proposal for Change

  49. Slide 49: Farallon's Proposal for Change Could Unlock Substantial Value

    FARALLON | Farallon’s Proposal for Change Could Unlock Substantial Value 49 Refocus R&D spending ▪ Avoid the mistakes made with cabozantinib, in which the Company conducted w asteful trials to expand indications based on small data sets and unpromising results ▪ Restrict zanzalintinib development to

  50. Slide 50: Refocus R&D Spending

    FARALLON | Refocus R&D Spending Gate spending on zanzalintinib to only those applications with an exceptionally clear advantage over the current standard of care ▪ Ensure that Phase 1 data are adequate and meaningfully differentiated from competition prior to initiating further trials 50 1 Integrate

  51. Slide 51: Other Peers Provide a Blueprint for Exelixis to Follow

    FARALLON | Other Peers Provide a Blueprint for Exelixis to Follow 51 Source: Financial data from FactSet; pipeline data from company websites and clinicaltrials.gov. TSR and valuation data for A lny lam and Exelixis as of March 17, 2023. TSR and valuation data for Seagen as of February 24, 2023, the

  52. Slide 52: A More Efficient EXEL Could Be Worth at Least $40 per Share

    FARALLON | We Believe a More Efficient EXEL Could Be Worth at Least $40 per Share… 1. Source: FactSet, Jefferies estimates and Farallon analysis. Model assumes cabo patent expires in 2030 and Exelixis offers a 1 0% price discount and maintains 75% market share; model also assumes that R&D spend is r

  53. Slide 53: And Other Commentators Agree

    FARALLON | …And Other Commentators Agree 1 53 An area of particular interest amongst investors has been the company’s R&D expenses, which has grown significantly in recent years (from ~$90M in 2016 when Cabometyx was approved in second - line kidney cancer… to guidance of nearly $1B in 2023. Excludi

  54. Slide 54: Develop a Comprehensive Capital Allocation Strategy

    FARALLON | Develop a Comprehensive Capital Allocation Strategy 54 2 We are pleased that Exelixis recently announced a share repurchase program in response to our suggestion, but we believe the current authorization does not go far enough ▪ We believe Exelixis should increase its share repurchase aut

  55. Slide 55: Refresh the Board and Enhance Alignment with Shareholders

    FARALLON | Refresh the Board and Enhance Alignment with Shareholders 55 3 We believe Exelixis should engage in active Board refreshment with the assistance of a respected independent search firm ▪ Seek diverse perspectives and experienced leaders to challenge the status quo ▪ The addition of Farallo

  56. Slide 56: Farallon's Nominees Bring Relevant Experience

    FARALLON | Farallon’s Nominees Bring Relevant Experience 56 3 Biography Relevant Expertise Tom Heyman ▪ Interim, part - time CEO of Interlaken Therapeutics ▪ President of Johnson & Johnson Development Corp., the corporate venture capital group of Johnson & Johnson (2015 – 2019) ▪ Global Head of Busi

  57. Slide 57: Re-examine Executive Compensation Structure

    FARALLON | Re - examine Executive Compensation Structure 57 3 We believe Exelixis should focus the annual incentive plan on a more limited number of targeted performance metrics that align with a more focused strategy and long - term shareholder interests ▪ The annual incentive plan currently uses m

  58. Slide 58: Improve Investor Relations and Engage with Investors and Analysts

    FARALLON | Improve Investor Relations and Engage with Investors and Analysts 58 4 We believe Exelixis should provide a clear roadmap for the Company’s strategy The description of the strategy should be sufficiently detailed, with clear goals and KPIs to create a compelling investment narrative and a

  59. Slide 59: Conclusion

    INVESTOR PRESENTATION Conclusion

  60. Slide 60: We Believe More Change Is Required

    FARALLON | We Believe More Change is Required 60 We believe the Board’s “accelerated refreshment” – which it initiated only after our nominations – does not go far enough ▪ The Board had many years to refresh its composition and replace long - tenured directors and did not do so prior to our involve

  61. Slide 61: Shareholders Should Support Farallon's Nominees to Drive Meaningful Change

    FARALLON | Shareholders Should Support Farallon’s Nominees to Drive Meaningful Change 61 We Believe Exelixis Has Underperformed; Meaningful Change Is Needed Shareholders Should Vote for Change by Supporting Our Candidates ▪ Despite its advantages, Exelixis has underperformed for many years — Exelixi

  62. Slide 62: Please Vote the WHITE Card to Support Meaningful Change at Exelixis

    FARALLON | Please Vote the WHITE Card to Support Meaningful Change at Exelixis 62 Brokers and Banks: (212) 929 - 5500 All Others Call Toll - Free: (800) 322 - 2885 Email: proxy @mackenziepartners.com Vote the WHITE proxy card We urge you to support change at Exelixis by voting the WHITE universal pr

  63. Slide 63: Appendix: Nominee Biographies

    INVESTOR PRESENTATION APPENDIX Nominee Biographies

  64. Slide 64: Nominee Biographies

    FARALLON | Nominee Biographies 64 Nominee Current & Past Affiliations Experience Tom Heyman Former President Johnson & Johnson Innovation + Interim, part - time CEO of Interlaken Therapeutics, a development - stage biotechnology company focused on rare diseases + Former President of Johnson & Johnso

  65. Slide 65: Nominee Biographies (Continued)

    FARALLON | Nominee Biographies (Continued) 65 Nominee Current & Past Affiliations Experience Dave Johnson Managing Partner Caligan Partners LP + Partner and Co - Founder of Caligan Partners, an investment firm focused on small - and mid - cap life sciences companies + Previously served as Managing D

  66. Slide 66: Nominee Biographies (Continued)

    FARALLON | Nominee Biographies (Continued) 66 Nominee Current & Past Affiliations Experience Bob Oliver Former President & CEO Otsuka America + Most recently served as President and CEO of Otsuka America Pharmaceutical, where he was responsible for overseeing the company’s oncology, neuroscience, ca

  67. Slide 67: Appendix: Exelixis Products and Pipeline

    INVESTOR PRESENTATION APPENDIX Exelixis Products and Pipeline

  68. Slide 68: Overview of Exelixis' Products and Pipeline

    FARALLON | Overview of Exelixis ’ Products and Pipeline 68 Source: Company filings. Product / Candidate Primary Modality Indications Status Marketed Products CABOMETYX ® ( cabozantinib ) Kinase inhibitor Renal cell carcinoma Hepatocellular carcinoma Differentiated thyroid cancer Approved for use in

  69. Slide 69: Overview of Exelixis' Cabozantinib Extension Pipeline

    FARALLON | Overview of Exelixis ’ Cabozantinib Extension Pipeline 69 Source: Company website. Therapeutic Area Phase 1 Trials Phase 2 Trials Phase 3 Trials Genitourinary Cancers 7 10 4 Gastrointestinal Cancers 4 8 1 Thyroid Cancer 1 1 - Lung Cancer 2 3 1 Gynecologic Cancers 1 1 - Neuroendocrine Tumo

  70. Slide 70: Appendix: Relative TSR

    INVESTOR PRESENTATION APPENDIX Relative TSR

  71. Slide 71: Exelixis Has Underperformed Peers and Indices Over Most Time Periods

    FARALLON | Exelixis Has Underperformed Peers and Indices Over Most Time Periods 71 Relative TSR 1 1 - Year 3 - Year 5 - Year 15 - Year 20 - Year Since IPO vs. Close Peers (17%) (9%) (36%) (371%) (820%) (134%) vs. Proxy Peers (23%) 0% (37%) (517%) (962%) (191%) vs. S&P 400 (2%) (44%) (92%) (314%) (75

  72. Slide 72: Appendix: Important Information

    INVESTOR PRESENTATION APPENDIX Important Information

  73. Slide 73: Disclaimer

    FARALLON | Disclaimer 73 The views expressed in this presentation represent the opinions of Farallon Capital Management, L . L . C . and its affiliates (collectively, “Farallon”) and are based on publicly available information with respect to Exelixis , Inc . (“ Exelixis ” or the “Company”) and the

  74. Slide 74: Important Information

    FARALLON | Important Information 74 Farallon, together with certain other persons acting as participants in the solicitation of shareholders of the Company by Farallon in connection with the Company’s 2023 annual meeting of shareholders (the “ 2023 Annual Meeting”), have filed a definitive proxy sta

Exelixis — Proxy Contest (May 2023) on 6ix