Yield10 Bioscience, Inc. · OTC:YTENQ
Yield10 Bioscience — Investor Presentation (August 2017)
20 slides from Yield10 Bioscience's investor presentation, August 2017
Slide 1: Yield10 Bioscience Investor Presentation
Yield10 Bioscience, Inc. (NASDAQCM:YTEN) Investor Presentation Yield10 is developing new technologies to achieve step-changes in crop yield to enhance global food security Today 2017 August
Slide 2: Safe Harbor Statement
Safe Harbor Statement* The statements made by Yield10 Bioscience, Inc. (the “Company,” “we,” “our” or “us”) herein regarding the Company and its business may be forward-looking in nature and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forw
Slide 3: Company Overview
Company Overview Yield10 Bioscience is developing technologies to enhance global food security • Headquartered in Woburn, MA USA • Oilseeds center of excellence in Saskatoon, Canada Yield10 is bringing extensive expertise and track record in optimizing the flow of carbon in living systems to the agr
Slide 4: Yield10: A Compelling Market Opportunity
Yield10: A Compelling Market Opportunity Crop yield is the key value driver in the Ag sector and the key to addressing food security Y10 is…aligned with compelling megatrends 9 October 2009 • Global prosperity and population growth creates reliable long-term Revised June, 2015 demand for ag-innovati
Slide 5: Value Creation
Value Creation Yield10’s gene traits may enable value creation through step-change increases in crop yield Value Creation Crop 2016 2016 Total Annual Value Harvest Value in Potential Corn Billions Tonnes/ Target Annual Bushels Yield Potential Increase Value in Soybean Billions Canola1 18.4 M tns $9.
Slide 6: Yield10 Business Strategy
Yield10 Business Strategy Building and Capturing Value from Yield10 Technologies • Recognize our role as a trait provider to the seed sector • Participate in the AG industry value sharing model • Historically ~50% of value to farmer and ~50% shared among seed company and trait innovator • Discover t
Slide 7: Recent Accomplishments
Recent Accomplishments Started C3003 Field Test for C3003 in Camelina and canola Submitted an “Am I regulated?” letter to USDA-APHIS for genome-edited Camelina Reported results showing that trait C4001 produces significant increases in plant yield Signed a research collaboration with NRC to
Slide 8: Yield10: Trait Gene Selection Criteria
Yield10: Trait Gene Selection Criteria Yield10 has a rich pipeline of yield gene trait leads but must be selective in those we choose to pursue on our own • Does the gene trait bring new science to a known yield limitation? • Acreage and revenue potential • Effective in all varieties of multiple cro
Slide 9: Trait Genes in Development
Trait Genes in Development Yield10 has a rich pipeline of crop traits and many opportunities exist for licensing and/or partnerships Value Genetic Genome Trait Current Activity, Next Steps Driver Engineering Editing Smart Grid Camelina 1st & 2nd Gen in field testing C3003 Seed yield (1st & 2nd Gen)
Slide 10: Novel Yield Trait Gene: C3003
Novel Yield Trait Gene: C3003 Advancing Development of C3003 in Key Oilseed Crops and Rice 2017 field tests of C3003 underway • Testing 1st & 2nd generation C3003 in Camelina • Testing 1st generation C3003 in canola • Study results on seed yield due in Q4 2017 • Additional longer lead data, e.g. oil
Slide 11: C3003 Trait Development Timeline
C3003 Trait Development Timeline Indicative Proof Point Timelines for C3003 Year Crop/Trait 2017 2018 2019 2020 Camelina/Gen 1 C3003 Field test data (Q1) Translation Camelina/Gen 2 C3003 Greenhouse data (Q1) Field trial Field test data (Q4) Camelina/Gen 3 C3003 TBD* Canola/Gen 1 C3003 Field test
Slide 12: The Potential for Genome Editing in Agriculture
The Potential for Genome Editing in Agriculture Potential to Develop Advanced Crop Traits using Genetic Engineering having “Nonregulated Status” • Achieving “deregulated” status for traditional biotech traits is time consuming and expensive • Genome editing techniques (eg. CRISPR) to reduce the acti
Slide 13: Yield10 Technology Platform Overview
Yield10 Technology Platform Overview Discovery paradigm based on metabolic pathway engineering expertise, enables the intelligent targeted manipulation of specific gene combinations The “Smart Carbon Grid for Crops” • Metabolic engineering platform to improve carbon capture and conversion efficiency
Slide 14: Global Regulatory Genes to Increase Biomass Yield
Global Regulatory Genes to Increase Biomass Yield Used transcriptome-based regulatory association networks to identify candidate regulatory genes predicted to increase photosynthesis and biomass yield Global regulatory gene candidates identified Complex Gene interaction network (C4001, C4002, C4003)
Slide 15: Measurement of Photosynthetic Parameters for C4001
Measurement of Photosynthetic Parameters for C4001 Key photosynthetic parameters increased in C4001 plants • Multiple photosynthetic parameters measured • Results: Observed up to a 75% increase in electron transport rate (ETR) per unit leaf area around photosystem I and II ETR(PSI) ETR(PSII) µmol el
Slide 16: Regrowth of C4001 Lines
Regrowth of C4001 Lines • 4 plants from each line were grown in greenhouse • Dry weight of biomass and roots measured • Results: 75-100% increase in leaf and stem biomass; 85-145% increase in root mass Leaf, Stem, and Root Biomass 120 100 Leaves & stems 80 Dry Weight 60 Leaf and (g) Stem 40 n=4 Root
Slide 17: Evaluation of C4001 in Key Crops: Rice
Evaluation of C4001 in Key Crops: Rice • C4001 genes are present in major crops (e.g. corn, rice, wheat) • Transformed rice with C4001 gene from switchgrass and rice • 1st generation plants are growing in greenhouse • Working towards producing 3rd generation plants that will enable us to quantitate
Slide 18: Signed Collaboration for New Wheat Traits
Signed Collaboration for New Wheat Traits • Signed two-year collaboration with The National Research Council of Canada to identify new traits to improve yield and drought tolerance in North American wheat • Collaboration is with Yield10’s wholly owned Canadian subsidiary, Metabolix Oilseeds • Yield1
Slide 19: Upcoming Milestones
Upcoming Milestones Yield10 is working to progress our yield enhancement technologies and build collaborations • Report on progress on C3003 with additional constructs and crops • Q4 Report field test data from 2nd generation C3003 trait in Camelina • Q4 Report field test data from 1st generation C3
Slide 20: Investment Considerations
Investment Considerations Yield10 designs precise alterations to gene activity and the flow of carbon in food and feed crops to produce higher yields with lower inputs of land, water or fertilizer Leverages a large historical investment in advanced metabolic engineering into a new arena • More than
Yield10 Bioscience — Investor Presentation (August 2017) on 6ix