Altria Group, Inc. · NYSE:MO
Altria — CPDD 2022
11 slides from Altria's conference presentation, Jun 12, 2022
Slide 1: Comparison of Cigarette Dependence between Adult Menthol and Non-Menthol Smokers
Comparison of Cigarette Dependence between Adult Menthol and Non-Menthol Smokers Lai Wei*, Pavel Lizhnyak, Andrea Vansickel, Raheema Muhammad-Kah, Edward Largo Center for Research and Technology Altria Client Services LLC, Richmond, VA 23219 Lai Wei | Altria Client Services LLC | Regulatory Affairs
Slide 2: Cigarette Smoking and Menthol
Cigarette Smoking and Menthol Number of Adult (18+) Menthol and Non-menthol Cigarette Smokers (in Millions) National Survey on Drug Use and Health (NSDUH), 2011-2020 60 56.0 54.8 54.1 54.5 51.0 50.5 50 47.9 46.8 45.6 40.3 Total 40 34.4 34.6 33.0 33.0 31.3 30.8 28.9 27.9 26.8 30 22.6 Non-Menthol 20 1
Slide 3: FDA's Evaluation on Menthol in Cigarettes
FDA’s Evaluation on Menthol in Cigarettes ▪ FDA’s Preliminary Evaluation (2013) ▪ For cigarette dependence, it concluded: ▪ Menthol smokers are more likely to smoke their first cigarette within five minutes of waking compared to non-menthol smokers. ▪ Menthol in cigarettes is likely associated with
Slide 4: Method
Method Analysis Objective: Compare cigarette dependence between menthol and non-menthol smokers. ▪ The Population Assessment of Tobacco and Health (PATH) Study ▪ Sponsored by NIH and FDA ▪ On-going nationally representative, longitudinal cohort study of US youth and adults, which generates epidemiol
Slide 5: Tobacco Dependence Index (TDI)
Tobacco Dependence Index (TDI) ▪ Developed by Strong et al. (2017) based on existing questions in the PATH survey questionnaire ▪ To characterize tobacco dependence across a range of tobacco products including cigarettes, e-cigarettes, cigars, hookah, and smokeless tobacco products ▪ Validated based
Slide 6: Average Number of Cigarettes per Day
Average Number of Cigarettes per Day Age 18-24 25+ Average Number of Cigarettes per Day among PATH Wave 4 Current Established Cigarette Smokers 8.7 Menthol 11.5 Overall 12.9 9.5 * Non-Menthol 14 Menthol 11.2 Race/Ethnicity NHW NHB NHO HISP * 12.7 Non-Menthol 13.5 Menthol 10.2 11.1 7.9 • Non-menthol
Slide 7: Time to First Cigarette
Time to First Cigarette Average Time to First Cigarette (in Minutes) Time to First Cigarette (in Minutes) Response Distribution among PATH Wave 4 Current Established Cigarette Smokers among PATH Wave 4 Current Established Cigarette Smokers 0 20 40 60 80 100 120 Within 5 min 6-30 min 31-60 min >60 mi
Slide 8: Heaviness of Smoking Index (HSI) & Tobacco Dependence Index (TDI)
Heaviness of Smoking Index (HSI) & Tobacco Dependence Index (TDI) Heaviness of Smoking Index (HSI, with Range 0-6) Tobacco Dependence Index (TDI, with Range 0-5) among PATH Wave 4 Current Established Cigarette Smokers among PATH Wave 4 Current Established Cigarette Smokers 0 1 2 3 4 5 6 0 1 2 3 4 5
Slide 9: Summary of Findings
Summary of Findings ▪ Our analyses of PATH Wave 4 data indicates that menthol cigarette smoking is not associated with increased cigarette dependence compared to non-menthol cigarette smoking. ▪ Conversely, we found evidence of lower level of dependence among current adult menthol smokers. These fin
Slide 10: References
References Curtin GM, Sulsky SI, Van Landingham C, Marano KM, Graves MJ, Ogden MW, Swauger JE. Primary measures of dependence among menthol compared to non-menthol cigarette smokers in the United States. Regulatory Toxicology and Pharmacology. 2014 Aug 1;69(3):451-66. Frost-Pineda K, Muhammad-Kah R,
Slide 11: Thank You
Thank You Please contact us if you have any questions. Lai Wei (lai.wei@altria.com) Principal Scientist at Altria Client Services, LLC 601 E. Jackson St., Richmond, VA, 23219 Special acknowledgements to my co-authors: Pavel Lizhnyak, Andrea Vansickel, Raheema Muhammad-Kah, and Edward Largo 11 Lai We