Frontage Holdings Corp. · HKEX:1521
Frontage — Investor Presentation (December 2025)
37 slides from Frontage's investor presentation, December 2025
Slide 1: Frontage Europe Overview
@® FRONTAGE Frontage Europe Overview
Slide 2: Our Vision and Values
Our Vision and Values Quality Integrity We are committed to We believe in Our Vision excellence in the honesty, reliability results we achieve, and accountability in To become one of the top five and how we achieve our words and them. behavior. global, science-driven CRO company, providing high qual
Slide 3: Integrated Discovery and Development Services
Integrated Discovery and Development Services Drug Discovery DMPK Safety & Bioanalytical & Product Clinical Trials Central Labs AgroChem Toxicology Genomics Development • LCMSMS (SM, • API Synthesis • Clinical • Clinical • Radio-chemical • Discovery • In Vitro ADME • IND Enabling Pegylated, Centers
Slide 4: The Value We Bring to Our Clients
The Value We Bring to Our Clients Frontage Laboratories, Inc. is a global contract research organization (CRO) advancing drug discovery and development through integrated laboratory, analytical, and clinical services. We will leverage our strengths to drive your projects forward Scientific Expertise
Slide 5: Business Overview – Three Continents, One System
Business Overview – Three Continents, One System Safety &Toxicology BA & DMPKc BA Lab (Small DMPK CMC CTM Molecule) Drug Screening 1600+ Safety & BA & CMC & Central Lab Global Staff Toxicology Milan BA & DMPK CMC & Central Lab Chicago DMPK Weihai API product Vancouver Zhengzhou CDMO Discovery Exton
Slide 6: Frontage Global Bioanalytical Overview
Frontage Global Bioanalytical Overview © 2025 Frontage Laboratories. All Rights Reserved
Slide 7: Bioanalytical Services
Bioanalytical Services Team & Small Biomarker Biologics Facilities Molecule 500+ 150,000 + 3000+ 1 million 200+ 300,000+ 150+ employees Sq ft lab methods samples +/ year projects/year samples/year methods 500+ 100+ • Molecules: peptides, projects/year LC-MS/MS • Molecules: Cytokines, proteins, monoc
Slide 8: Competencies of Bioanalytical Services
Competencies of Bioanalytical Services Over 22 years of excellence in scientific expertise and quality to address your complex drug development needs Variety of Strong Scientific Outstanding Quality Technology Expertise & Compliance Platforms & Capacity • 70% of staff have advanced • Outstanding aud
Slide 9: State of the Art Facilities
State of the Art Facilities • Secure site (keycard access; alarm and video system, monitored by contractor) • Server room and archive have FM200 inert gas fire suppression system and separate access security • Expanded sample management with over 15 personnel and over 40 ultralow freezers • Validate
Slide 10: Frontage Europe Bioanalytical Overview
Frontage Europe Bioanalytical Overview © 2025 Frontage Laboratories. All Rights Reserved
Slide 11: Frontage Europe
Frontage Europe Located in Nerviano, Milan (Italy) ▪ 2,500 m2 area ▪ Bioanalysis (small/large molecules) ▪ Isotope Chemistry ▪ Central lab.
Slide 12: Frontage EU- Ground floor
Frontage EU- Ground floor Total area 1450 m2 Labs & offices 888 m2 Administration 136 m2 Central lab, Sample tracking offices & archive 116 m2 labs &sample storage 121 m2 labs expansion area Radiosynthesis 177 m2 250 m2 labs
Slide 13: Frontage EU – First floor
Frontage EU – First floor Total area 485 m2 Lab &offices 399 m2 Bioanalytical lab 260 m2 sample prep. LC-MS/MS BioAssay multi-platforms analytical instruments sample prep.
Slide 14: Carbon Footprint
Carbon Footprint Frontage EU is committed to decrease the carbon footprint: ✓ Primary analysis: data collection Phase 1 Phase 2 Analysis Evaluation ▪ Evaluation and carbon footprint calculation (GHG Protocol) ▪ Strategy: Identification of Improvement areas Phase 4 Phase 3 ▪ Action: Improvement Plan
Slide 15: Frontage EU Organization Chart
Frontage EU Organization Chart Frontage Lab. Frontage Lab. Global VP QA CEO QA/Compliance Business Development Administrative Interim Site Head Support CSV/IT Sample Tracking GLP BioA Lab Biologics DMPK Central Lab (LC-MS/MS) BioAssay Pharmacokinetics Isotope Chemistry Metabolite ID
Slide 16: Certifications
Certifications ✓ GLP Compliance (Ministry of Health) ✓Health & Safety regulations Compliance (ATS local authority)
Slide 17: Roadmap
Roadmap Start off 29 January 2025 GLP Certification ✓ PK/TK & ADME area of expertise Getting on 16 May 2025 ATS Certification ✓ compliance with health and safety regulations ✓ compliance with requirements for execution of 11 Aug. 2025 ATS Certification activities 02 Dec. 2025 AIFA authorization Phas
Slide 18: Core services
Core services Small Molecule Bioanalysis • PK LC-MS/MS Large Molecule Bioanalysis • PK; ADA; Biomarkers Central Lab • Kitting; Logistics Radio Synthesis • Radiosynthesis by 14C and 3H; Stable Label Internal Standard (SLIS) • Metabolite profile and identification
Slide 19: GLP BioA Lab expertise
GLP BioA Lab expertise LC-MS/MS Eight team members (3 senior scientists) • >15 years average exerience in CRO context • Special focus on small molecules ✓ Assay Development/ Transfer / Validation ✓ Preclinical/Clinical Sample Testing ✓ PK/TK Pharmacokinetics Assays Previous experience in leading pha
Slide 20: LC-MS/MS Equipments
LC-MS/MS Equipments • SCIEX API 6500 (1) • SCIEX API 5500 (1) • SCIEX API5000 (2) • 4000QTRAP (1) • StarLet Hamilton robotic liquid handler for sample prep.
Slide 21: Turnaround time for LCMS Assays
Turnaround time for LCMS Assays Method Development/ Validation Timelines Method Development/ Transfer 8-10 business days Method Validation lab work 10-15 business days Draft report to the Sponsor 4 weeks after end method validation lab work Submission of final report 3-4 weeks from Sponsor’s comment
Slide 22: Biologics Bioassay expertise
Biologics Bioassay expertise Biologics BioAssay Five team members >15 years average experience in CRO context ✓ Assay Development/ Transfer / Validation ✓ Preclinical/Clinical Sample Testing ✓ PK/TK Pharmacokinetics Assays ✓ Immunogenicity: ▪ ADA – Anti-Drug Antibody Assays ▪ NAb – Neutralizing Anti
Slide 23: Biologics Bioassay Equipments
Biologics Bioassay Equipments • Spectramax ID3 (2) • Glomax Navigator (1) • MSD QuickPlex SQ120MM (1) • Quanterix Simoa HD-X Analyzer (1) • Tecan Spark20M (1)
Slide 24: Turnaround time for Biologics BioAssays
Turnaround time for Biologics BioAssays Method Development/ Validation Timelines Assay Transfer/ Qualification PK LBA: 10 business days ADA: 15 business days BM: 10 business days Method Validation lab work PK LBA: 15 business days ADA: 20 business days BM: 10-15 business days Draft report to the Spo
Slide 25: Bioanalytical Laboratory Information Management
Bioanalytical Laboratory Information Management Watson 7.6 ➢ Supports complex study design ➢ Enables efficient sample tracking: • history, storage, analysis ➢ Enables to configure: • acceptance criteria • reassay selection • ISR criteria ➢ Performs statistics ➢ CFR21 part 11 compliant
Slide 26: DMPK Expertise
DMPK Expertise Isotope Chemistry Services • Customized radiosynthesis (14C, 3H, 35S, 125I) • Customized stable label strategies (13C, 2H, 15N) for Stable Label Internal Standard (SLIS) • Purification and chiral separation of radiolabeled compounds • Delivery of radiolabeled compounds (e.g., salt, so
Slide 27: DMPK Equipments
DMPK Equipments Isotope Chemistry MetID • CEM Microwave synthesizer • ThermoFisher Orbitrap QExactive • Biotage SELEKT® Flash chromatography • Thermofisher Orbitrap LTQ system system • Varian preparative HPLCs • UV and Radiochemical detectors • PerkinElmer HPLCs with radiochemical and UV/VIS detecto
Slide 28: DMPK Turnaround time
DMPK Turnaround time Isotope Chemistry Activity Timelines Average purification time 1 week Preparation of SLIS 1-2 months Radiosynthesis of small 14C-labeled molecules ~3 months (including pilot trial) 3-4 steps synthesis Release of analytical certification and scientific report 1-2 weeks Met-ID Tim
Slide 29: Pharmacokinetics Expertise
Pharmacokinetics Expertise • Preclinical: Pharmacokinetics and Toxicokinetics for Non-GLP/GLP studies in line with EMA & FDA guidelines. ✓ Non-compartmental and compartmental analysis, dose proportionality, food effect, bioequivalence/bioavailability, inter-species scaling (Phoenix WinNonlin, Watson
Slide 30: Pharmacokinetics timelines
Pharmacokinetics timelines Pharmacokinetics Activity Timelines Fast turn-around 5 days (PK tabulated results) Reporting 1-2 weeks from data release
Slide 31: Central Lab
Central Lab Frontage Central Lab Milan, Italy EU Multiple sites- Medicover (Partner) Frontage Central Lab Exton, PA Japan -Mediford (Partner) Frontage Central Lab China Australia - St Vincent’s Heath Network (Partner) Australia - Prove Clinical (Partner) Germany- LKF (Partner) The European Central L
Slide 32: Frontage’s Project Management System
Frontage’s Project Management System
Slide 33: Central Lab services
® Central Lab services Lab Testing Chemistry, immunoassay, allergen, autoimmune, infectious disease, hematology, urinalysis, coagulation, flow cytometry, Logistics and Project Management Kit design and distribution, lab manual creation, sample management, shipping service, data management histology/
Slide 34: Central Lab logistic service
Central Lab logistic service Lab Manual SIV Training First draft of lab manual Provide virtual SIV training within two weeks of on PPT slides contract execution Kits Design & Build Kits and Labels Packets Lab kit design based on the Kits and label packets study protocol and schedules distribution to
Slide 35: Kit Design and Build
Kit Design and Build Custom designed kits built to your specifications • Instructions • Collection Devices • Collection Tubes • Sample Requisitions and Labels • Return Shipping Information • Independent quality control review for each kit
Slide 36: Laboratory Manual
Laboratory Manual • Detailed collection, storage, and shipping instructions based on method development and laboratory requirements • Draft version of Laboratory Manual with quick turnaround time per client request • Provide virtual SIV training on PPT slides
Slide 37: Thank you!
Thank you! © 2025 Frontage Laboratories. All Rights Reserved 38
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