Masimo Corporation · NASDAQ:MASI
Masimo — Investor Day (December 2025)
22 slides from Masimo's investor day presentation, Dec 3, 2025
Slide 1: Outcomes Research Consortium
OUTCOMES RESEARCH Consortium Providing the evidence for evidence-based medicine©
Slide 2: Perioperative Mortality
Perioperative Mortality Daniel I. Sessler, M.D. Vice President for Clinical and Outcomes Research Professor of Anesthesiology UTHealth, Houston www.OR.org DS@OR.org
Slide 3: Dylan Thomas, 1954 quote
Dylan Thomas, 1954 Time held me green and dying, But I sang in my chains like the sea.
Slide 4: Do not go gentle into that good night
Dylan Thomas, shortly before dying Do not go gentle into that good night, Old age should burn and rave at close of day; Rage, rage against the dying of the light.
Slide 5: 30-day Postoperative Mortality
30-day Postoperative Mortality Nepogodiev, Lancet 2019
Slide 6: Causes of Perioperative Mortality
Causes of Perioperative Mortality Attributable risk • Bleeding 17% • Myocardial injury 16% • Sepsis 12% Respiratory events • ≈45,000 US pts/yr need emergency ventilation – 40% lethal • 40% of ward cardiopulmonary arrests are respiratory – 80% lethal • Largely preventable VISION Investigators CMAJ 20
Slide 7: Continuous Ward MAP Monitoring (n=312)
Continuous Ward MAP Monitoring (n=312) Routine vital signs missed half the patients with MAP <65 mmHg for 15 minutes Turan, Anesthesiology 2019
Slide 8: Respiratory Complications
Respiratory Complications Respiratory arrests should not kill hospitalized patients Causes •Obstruction •Respiratory muscle weakness, including residual blocks •Reduced ventilation, often from pain •Impaired respiratory control And…
Slide 9: Opioids & Sedatives and Cardiac Arrest
Opioids & Sedatives Cardiac Arrest No Cardiac Arrest (n=96,554) (n=12,180,137) OR 95%CI Opioids & Sedatives 41% 22% 3.47 (3.40, 3.54) Opioids only 28% 31% 1.81 (1.77, 1.85) Sedatives only 14% 14% 1.82 (1.78, 1.87) Neither opioids nor 17% 33% Ref sedatives Overdyk, PLoS One, 2018
Slide 10: Blinded Saturation Over Time
Blinded Saturation Over Time Nurses missed 90% of patients who had 1 continuous hour of saturation <90% More than 10% of ward saturations were <90% Sun, A&A 2015
Slide 11: Opioid-induced Respiratory Depression
Opioid-induced Respiratory Depression Closed-claims analysis •77% of episodes = death or severe brain injury •88% within 24 hours of anesthesia 97% deemed preventable •42% within 2 hours of last nursing check Potential causes •Multiple prescribers •Potentiating non-opioid sedatives Lee et al, Anesth
Slide 12: Vital Sign Monitoring
Vital Sign Monitoring We monitor vital signs about the way we did a half-century ago We’re still stuck on “failure to rescue” rather than preventing complications Continuous ward vital sign monitoring may help
Slide 13: Arrests Preceded by Abnormalities
Arrests Proceeded by Abnormalities 100 90% 95 85% 90 80% 75% Most in-hospital 85 70% cardiorespiratory 80 arrests preceded by Mortality, % 75 70 hours of vital sign 65 abnormalities 60 55 50 0 1 2 3 0 1 2 3 Abnormal Severely Abnormal Number of Pre-Arrest Abnormal Vital Signs Anderson, Resuscitation
Slide 14: Dartmouth 10-year Outcomes Study
Dartmouth 10-year Outcomes Study Continuous Masimo surveillance monitoring of general ward patients (n=111,488) No OIRD deaths among continuously monitored patients One OIRD-related death among patient for whom continuous monitoring was available but not used Continuous SpO2 monitoring reduced death
Slide 15: Continuous Ward Monitoring Helps
Continuous Ward Monitoring Helps ‘Before and After” 8-month comparative outcomes study Continuous SpO2 monitoring using Masimo SET with Patient SafetyNet King Saud Medical City - 1,200 bed hospital Before Patient After Patient P value SafetyNet SafetyNet ↓ Mortality CPR Event Rate 3.3% 1.95% 0.01 ↓
Slide 16: Impact to Cost of Care
Impact to Cost of Care Dartmouth clinical outcome study using Masimo SET with Patient SafetyNet Cost-of-care analysis of 31,993 ward patients admitted July 2016 – Dec 2019 Operating margin savings of $5,500 per patient rescue prevented and $10,700 per patient for rescue/care transfer prevented Signi
Slide 17: CONSTANT Trial: Methods
CONSTANT Trial: Methods 500 Patients recovering from major noncardiac surgery Intermittent postop nursing vital signs per routine Continuous vital sign monitoring for 48 hours •Radius PPG and Patient SafetyNet Randomization •Blinded continuous vital sign monitoring •Unblinded continuous vital sign m
Slide 18: CONSTANT Trial: Primary Hypothesis
CONSTANT Trial: Primary Hypothesis Unblinded continuous ward monitoring reduces a composite of areas exceeding the thresholds of desaturation (<85%), bradypnea (<5 breaths/min), tachypnea (>25 breaths/min), tachycardia (heart rate >130 beats/min), bradycardia (heart rate <35 beats/min), mean arteria
Slide 19: CONSTANT Trial: Secondary Hypothesis
CONSTANT Trial: Secondary Hypothesis Unblinded continuous ward monitoring increases a composite of clinical interventions for desaturation, hypoventilation, tachypnea, tachycardia, bradycardia, and hypotension within 48 hours after major non-cardiac surgery.
Slide 20: Summary: Postop Mortality is Preventable
Summary: Postop Mortality is Preventable Postoperative deaths are world’s 3rd leading cause of death Major causes are cardiovascular and respiratory events •Preceded by vital sign abnormalities •Most are missed with conventional 4-hour vital sign monitoring Continuous ward monitoring is likely to: •
Slide 21: Carpe Diem
Carpe Diem
Slide 22: And that's all folks…
And that’s all folks… Selected OUTCOMES RESEARCH covers since 2023