Tango Therapeutics, Inc. · NASDAQ:TNGX
Tango Therapeutics — Corporate Update (October 2025)
20 slides from Tango Therapeutics's corporate update, Oct 23, 2025
Slide 1: Vopimetostat clinical update
Vopimetostat clinical update 23 October 2025 Exhibit 99.1
Slide 2: Disclaimer and safe harbor statement
Disclaimer and safe harbor statement Certain statements in this presentation may be considered forward-looking statements. Forward-looking statements generally relate to future events, Tango’s future financial and operating performance, goals, expectations, beliefs, development plans, as well as dev
Slide 3: Vopimetostat (TNG462) overview
Vopimetostat (TNG462) overview Oral, once a day, MTAP-selective PRMT5 inhibitor Potential best-in-class molecule with superior target coverage and safety profile A potential turning point in multiple hard to treat cancers, with demonstrated durable tumor control and favorable tolerability in the ong
Slide 4: Phase 1/2 study design
Vopimetostat phase 1/2 study DOSE ESCALATION MTAP-del solid tumors DOSE OPTIMIZATION Pancreatic cancer Lung cancer Histology agnostic cancers All pancreatic cancers are adenocarcinomas. All lung cancers are non-small cell histology.
Slide 5: Current and planned vopimetostat disclosures
Current and planned vopimetostat disclosures Data extract 1 Sept 2025 FU, follow-up. Active doses are defined as 200 mg QD and above. October 2025 2026 Phase 1/2 trial safety, tolerability and efficacy data 179 patients, 154 at active doses, 84 at go-forward dose (250 mg QD) Pancreatic cancer cohort
Slide 6: Vopimetostat has robust, durable clinical activity in multiple MTAP-del cancer types
Vopimetostat has robust, durable clinical activity in multiple MTAP-del cancer types Overall response rate (ORR) 27% across cancer types currently best-in-class*, FDA agreement on 250 mg QD go-forward dose Median progression-free survival (mPFS) 7.2 months and ORR 25% in 2L MTAP-del pancreatic cance
Slide 7: Efficacy matures over time
Vopimetostat efficacy matures over time Data extract 18 Aug 2025. Follow-up N ORR Median follow-up Any 127 20% 7.4 mo > 4 mo 114 22% 7.6 mo > 6 mo 85 27% 9.3 mo All patients dosed more than 6 months before data cutoff at 200 mg QD and above Median time to RECIST response 3.5 months Vopimetostat phas
Slide 8: 27% ORR across cancer types
Vopimetostat 27% ORR across cancer types Data extract 1 Sept 2025. Includes all tumor evaluable patients receiving 200 mg QD dose or higher more than 6 months prior to the data cutoff, including those remaining on study, progressed or withdrew. ORR/DCR in tumor evaluable patients, BOR rounded to the
Slide 9: Durable disease control with vopimetostat across cancer types
Durable disease control with vopimetostat across cancer types Data extract 1 Sept 2025. mPFS calculation includes all patients (n=143); spider plot represents only tumor-evaluable subset of patients (n=131). All tumor evaluable patients at active doses (n=131) Key points Overall mPFS 6.4 months PR p
Slide 10: 250 mg QD has a potential best-in-class safety profile
Vopimetostat 250 mg QD has a potential best-in-class safety profile Data extract 1 Sept 2025. Related AEs in ≥5% pts (n=84) Key points Median follow-up 6.1 months 8% dose reduction 0% discontinuation for related events No grade 4-5 related events Low grade GI side effects Vopimetostat AE profile sug
Slide 11: Pancreatic cancer cohort
Vopimetostat pancreatic cancer cohort Data extract 1 Sept 2025 *Includes all patients enrolled in the study more than 6 months prior to the data cutoff, including those remaining on study, progressed or withdrew. Includes one 1L patient. 64 pancreatic cancer patients at active doses* One prior thera
Slide 12: mPFS is 7.2 months in 2L pancreatic cancer
Vopimetostat mPFS is 7.2 months in 2L pancreatic cancer Data extract 1 Sept 2025. All 2L pancreatic cancer patients at 200 mg QD and above. *ORR ranging from 3-17% reported in published literature. Vopimetostat in 2L and 3L+ pancreatic cancer Summary Vopimetistat 2L mPFS 7.2 mo 2L ORR 25% Overall OR
Slide 13: mPFS in 2L pancreatic cancer more than twice historical SOC trials
Vopimetostat mPFS in 2L pancreatic cancer more than twice historical SOC trials Data extract 1 Sept 2025. a. Ikushima, ESMO Open, 2025. b. All tumor evaluable 2L patients at active doses and the only 2L patient at 160 mg QD. Historical data are derived from different clinical trials at different poi
Slide 14: Pivotal trial in 2L pancreatic cancer
Vopimetostat pivotal trial in 2L pancreatic cancer Pivotal study start planned 2026 Planning for 2L registration Rapid enrollment of ~300 patients anticipated given high unmet medical need in this patient population Approval in 2L pancreatic cancer after chemotherapy and/or RAS inhibitors is expecte
Slide 15: Vopimetostat + RAS(ON) inhibitors may provide chemotherapy free treatment for 1L MTAP-del pancreatic cancer
Vopimetostat + RAS(ON) inhibitors may provide chemotherapy free treatment for 1L MTAP-del pancreatic cancer Study update Cohort 1 complete (n=7) Exposures in active range for each compound Both combos well tolerated to date, early signs of activity Backfill ongoing with robust enrollment Cohort 2 en
Slide 16: Lung cancer cohort
Vopimetostat lung cancer cohort 41 lung cancer patients at active doses One or more prior therapy for advanced disease n=41 patients 12/41 pts more than 6 months since enrollment Median follow-up 4.7 months Enrollment by starting dose (QD) 200 mg n=13* 250 mg n=26 300 mg n=2 Data extract 1 Sept 2025
Slide 17: Histology agnostic cohort
Vopimetostat histology agnostic cohort Data extract 1 Sept 2025 Includes all patients enrolled in the study more than 6 months prior to the data cutoff, including those remaining on study, progressed or withdrew. 47 histology agnostic patients at active doses Histology agnostic cohort analysis exclu
Slide 18: 49% ORR in histology agnostic cohort
Vopimetostat 49% ORR in histology agnostic cohort Data extract 1 Sept 2025. ORR in tumor evaluable patients, BOR rounded to the nearest whole number. Tumor evaluable pts at active doses with >6 months follow-up (n=37) Key points ORR 49% mPFS 9.1 months DCR 89% 21/37 patients ongoing Median follow-up
Slide 19: 9.1 mo mPFS more than twice historical SOC trials in multiple indications
Vopimetostat 9.1 mo mPFS more than twice historical SOC trials in multiple indications mPFS (95% CI) 9.1 months (6.5 – 12.0) Durable activity in multiple late line, difficult to treat cancers provides: Further evidence of robust single agent activity Additional optionality for development in large p
Slide 20: Vopimetostat has the potential to be best-in-class and first-to-market
Vopimetostat has the potential to be best-in-class and first-to-market for large patient populations with high unmet need FDA alignment on 250 mg QD go-forward dose Strong activity across cancer types All histologies ORR 27%, mPFS 6.4 months 2L pancreatic cancer ORR 25%, mPFS 7.2 months Histology ag