Mimedx Group, Inc · NASDAQ:MDXG
Mimedx — Investor Presentation (June 2026)
25 slides from Mimedx's investor presentation, June 2026
Slide 1: Biomimetic Matrix Product Overview
® Biomimetic Matrix PRODUCT OVERVIEW 1 | US-GD-2600005 v2.0 Distributed By
Slide 2: Outline
Outline • Clinical Challenges of Complex • Product #, Sizes, & Wound Area Wounds Coverage • What is a Self-Assembling Peptide? • Application Guide • Product Introduction and Indications • Package Contents, Shelf Life, and for Use Storage • Key Benefits & Versatility for • Cautions and Contraindicati
Slide 3: The Stages of Healing Are Similar Throughout the Body
The Stages of Healing Are Similar Throughout the Body 3 | US-GD-2600005 v2.0 Distributed By
Slide 4: There Are Risk Factors that Impair Healing and/or Delay Wound Closure
There Are Risk Factors that Impair Healing and/or Delay Wound Closure1 Patient Defect/Wound Timing • Diabetes • Contamination or infection • Slow healing • Older age • Exposed tendon or bone • Chronic wound • Obesity • Recurrence • Not yet candidate for • Smoking • Irradiated tissue definitive closu
Slide 5: What Is a Self-Assembling Peptide (SAP)?
What Is a Self-Assembling Peptide (SAP)? • Short peptides made of essential amino acids • Synthetically manufactured • Supportive 3D scaffold that mimics the native Extracelluar Matrix (ECM) • Designed to support cell infiltration, revascularization, and tissue repair • Matrix can act as a barrier a
Slide 6: What Is G4Derm Plus?
What Is G4Derm® Plus? G4Derm Plus is an acellular flowable Extracellular Matrix (ECM) designed to optimally manage complex wounds. It supports healing and serves as an antibacterial barrier to protect the wound bed from external contamination.1 G4Derm Plus utilizes self-assembling peptide technology
Slide 7: G4Derm Plus in Complex Wounds
G4Derm Plus in Complex Wounds Designed to Support Host Tissue Repair2,3 & Antibacterial Protection4 Flowable matrix enters the wound, Cells begin infiltrating the scaffold The matrix serves as an antibacterial conforms to the wound surface and and attach to the peptide-based barrier, protecting the
Slide 8: G4Derm Plus Serves as a Scaffold for Cellular Infiltration and Capillary Ingrowth
G4Derm Plus Serves as a Scaffold for Cellular Infiltration and Capillary Ingrowth1 G4Derm Plus mimics the microarchitecture of G4Derm Plus supported revascularization in vivo. the native ECM. Immunohistochemistry staining of CD31 (blood vessels) Scanning Electron Microscopy (SEM) magnification in wo
Slide 9: G4Derm Plus Antibacterial Barrier
G4Derm Plus Antibacterial Barrier1 G4Derm Plus Forms a Barrier to External Bacterial Contamination of the Wound Surface ANTIBACTERIAL BARRIER In vitro study demonstrated that G4Derm Plus served as an effective antibacterial barrier for up to 7 days against: • Gram-positive bacteria* • Gram-negative
Slide 10: Indications for Use
Indications for Use G4Derm Plus may be used under the supervision of health care professionals for the local management of partial- and full-thickness wounds including: • Surgical wounds • Lower extremity ulcers including venous, arterial, • Pressure ulcers and mixed etiology • Diabetic ulcers • Fir
Slide 11: Key Benefits
Key Benefits • Biomimetic matrix • Allows for maximal wound bed that supports:1,2 contouring and filling soft • Revascularization tissue voids3 • Granulation tissue formation • Serves as a durable antibacterial barrier4,5 • Re-epithelization • Ready-to-use pre-filled Syringe • Up to 3-year shelf lif
Slide 12: Versatile for Wounds
Versatile for Wounds Application Considerations Biomimetic Matrix Serves as a Durable Antibacterial Barrier1,2 Wound Area Coverage (2 mL ≈ 25 cm2) Flexible Applicator Tip May Reach Deeper Wounds (Applicator Tip Length: ~ 12.5 cm) Coating Thickness of Flowable Matrix (~ 1 mm) Ready to Use a
Slide 13: Suitable for Wounds Across Diverse Surgical Specialties
Suitable for Wounds Across Diverse Surgical Specialties POTENTIAL EXAMPLES • Plastic Reconstruction • Foot and Ankle • Trauma • General • Vascular • Orthopedic • Spine • Burns 13 | US-GD-2600005 v2.0 Distributed By
Slide 14: Product Size, Storage, Shelf Life, & GTIN #
Product Size, Storage, Shelf Life, & GTIN # STORAGE SHELF LIFE • Store at +2°C to +30°C • Up to 3 Years (+36°F to +86°F) • Do not freeze • Avoid excessive heat • Keep dry G4Derm Plus 2 mL Syringe and Applicator Tip/Nozzle (Applicator Tip/Nozzle Length: ~ 12.5 cm) Syringe ~ Wound Area ~ Coating Produ
Slide 15: Application Guide
Application Guide1 Before Use: Read Instructions for Use. G4Derm Plus is intended for use in adults 18 years of age or older. Confirm there is no damage to pouches, Syringe, or flexible Applicator Tip. Do not use the product if damaged or leaks are noted. Do not use the product if the Syringe top ca
Slide 16: Application Guide (cont.)
Application Guide (cont.)1 3. Remove Top Cap 3. Hold the Syringe and remove the top cap. 4. Prime Syringe • Optional: If using the flexible Applicator Tip for application, connect the flexible Applicator Tip by securely attaching it to the syringe head. 4. Prior to G4Derm Plus application, prime the
Slide 17: Application Guide (cont.)
Application Guide (cont.)1 5. Dispense G4Derm Plus directly onto the wound by gently pressing the plunger rod. Apply enough product to coat the wound bed. Fill any void spaces. • Precaution: The recommended maximum patient exposure of G4Derm Plus is 10 g/day • 10g of G4Derm Plus = 5 units of 2 mL^ 6
Slide 18: Product Handling & Application Considerations
Product Handling & Application Considerations • G4Derm Plus is a flowable biomimetic wound matrix intended to facilitate controlled handling and application. • When applied continuously or intermittently, the product moves smoothly from the syringe with or without the flexible Applicator Tip. G4Derm
Slide 19: Product Is Provided Sterile Packaged for Single Use Only
Product Is Provided Sterile Packaged for Single Use Only Box Includes: • One sterile single-use pre-filled G4Med Plus Syringe (2 mL) • One sterile single-use flexible Applicator Tip • Instructions for Use (IFU) • 6 patient labels Shelf Life and Storage: • Up to 3-year shelf life • Store at +2°C to +
Slide 20: Precautions
Precautions • Keep out of the reach of children. • Not for injection. • The recommended maximum patient exposure of G4Derm Plus is 10 g/day. • G4Derm Plus is a sterile product. Do not re-sterilize. • Product is guaranteed to be sterile and nonpyrogenic unless the package is opened or damaged. • Do n
Slide 21: Contraindications
Contraindications1 Do not use G4Derm Plus on patients with a known sensitivity / previous allergic reaction to the product or any of its components. No contraindications related to contaminated wounds* 1. G4Med, Inc. G4Derm Plus: Instructions for Use. Document No. PL-0001 Rev 3.0. Brighton, MA. * Th
Slide 22: Biomimetic Matrix Regulatory Clearance
Biomimetic Matrix Regulatory Clearance 22 | US-GD-2600005 v2.0 Distributed By
Slide 23: 510(k) Regulatory Clearance
510(k) Regulatory Clearance • G4Derm Plus was 510(k) cleared in 2023 as a medical device. • Manufacturer: Gel4Med, Inc. U.S. Food and Drug Administration. 510(k) Premarket notification clearance letter: G4Derm / G4Derm Plus Synthetic Wound Matrix. 510(k) No. K222025. Silver Spring, MD, Center for De
Slide 24: Indication for Use
Indication for Use: G4Derm Plus may be used under the supervision of health care professionals for the local management of partial-and full-thickness wounds including pressure, and diabetic ulcers; lower extremity ulcers including those of venous, arterial and mixed etiology; surgical wounds; first-
Slide 25: Biomimetic Matrix
Biomimetic Matrix LEARN MORE ABOUT MIMEDX PRODUCTS 866.477.4219 customerservice@mimedx.com G4Derm Plus is owned and manufactured by Gel4Med Inc. and distributed by MIMEDX Group, Inc. MIMEDX is a trademark of MIMEDX Group, Inc. All other trademarks are owned by their respective owners. ©2026 MIMEDX G