Revelation Biosciences, Inc. · NASDAQ:REVB
Revelation Biosciences — 29th International Conference on Advances in Critical Care Nephrology: AKI and CRRT 2024
5 slides from Revelation Biosciences's conference presentation, Mar 12, 2024
Slide 1: Intravenous Gemini for Prevention of Acute Kidney Injury
Oral Presentation at the 29th International Conference on Advances in Critical Care Nephrology: AKI and CRRT - March 2024 Intravenous GeminiTM for Prevention of Acute Kidney Injury Prophylactic Administration of Gemini (intravenous PHAD®) Reduces Tissue Damage and Improves Kidney Function in a Rat M
Slide 2: Introduction and Methods: Gemini Reprograms Toll-Like Receptor 4 Signaling
Introduction Gemini is a proprietary formulation of phosphorylated hexaacyl disaccharide (PHAD), a synthetic, detoxified version of lipopolysaccharide (LPS). PHAD stimulates TLR4 to precondition immune cells, including early, robust induction of IL-10, followed by an attenuated induction of IL-6, an
Slide 3: Gemini Preserves Kidney Function and Reduces Injury
Gemini Preserves Kidney Function and Reduces Injury Kidney Function at 24 and 72 hours Kidney Injury at 72 hours Gemini pretreatment (0.35 mg/kg) significantly preserved kidney function with return to base line faster relative to untreated control animals (Figure 1a and 1b). A similar trend was obse
Slide 4: Gemini Significantly Attenuates Inflammatory Response
Gemini Significantly Attenuates Inflammatory Response Oral Presentation at the 29th International Conference on Advances in Critical Care Nephrology: AKI and CRRT - March 2024 Figure 3d. Neutrophilic Inflammation at 72 hours2 Figure 3a. Urinary CRP at 24 hours1 1N=16-28, dosed 24 and/or 48 hours pri
Slide 5: Gemini Clinical Evaluation Initiated: Discussion and Conclusions
Gemini Clinical Evaluation Initiated Discussion Improved kidney function and reduced necrosis likely due to reduction in pro-inflammatory activities, as observed in reduced neutrophil inflammation and reduced local and systemic CRP and IL-6 levels Gemini may halt necroinflammation feedback loop by r