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Xilio Therapeutics Announces Preclinical Data Demonstrating Anti-Tumor Activity and Tolerability of XTX301, a Tumor-Selective IL-12, at Society for Immunotherapy in Cancer Annual Meeting
WALTHAM, Mass., Nov. 12, 2021 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq:XLO), a biotechnology company developing tumor-selective immuno-oncology
About this update from Xilio Therapeutics, Inc.
[{"type":"text","content":"WALTHAM, Mass., Nov. 12, 2021 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq:XLO), a biotechnology company developing tumor-selective immuno-oncology therapies for patients with cancer, today announced data from preclinical studies of XTX301, an engineered tumor-selective interleukin-12 (IL-12) product candidate, demonstrating selective anti-tumor activity and favorable tolerability with minimal systemic activity. These data are highlighted in a poster at the Society for Immunotherapy in Cancer’s 36th Annual Meeting (SITC), which is being held virtually and in Washington, D.C., from November 10-14, 2021. In addition, Xilio will present an overview (poster #519) of its Phase 1/2 clinical trial design of XTX101, its tumor-selective anti-CTLA-4 monoclonal antibody product candidate, in patients with solid tumors. “The presentations at SITC exemplify the progress we’ve made at Xilio in 2021 with our pipeline of clinical and preclinical-stage tumor selective antibody and cytokine product candidates,” said Martin Huber, M.D., president of R&D and chief medical officer of Xilio. “IL-12 has the potential to be a meaningful treatment for patients with cancer, but current therapies are encumbered with severe toxicities due to their peripheral activity, leading to sub-optimal dosing and limited efficacy. Using our GPS platform, we have engineered XTX301 to achieve systemic delivery of tumor-selective IL-12, while avoiding the known side effect challenges. These preclinical data showcase our engineering efforts to activate XTX301 only when it is within the tumor microenvironment, resulting in the potential to achieve an optimized therapeutic index and enhanced anti-tumor activity. We look forward to further advancing this program, with plans to submit an investigational new drug application to the FDA in the second half of 2022.” XTX301, a Protein-Engineered IL-12, Exhibits Tumor-Selective Activity in Mice Without Peripheral Toxicities and is Well Tolerated in Non-human Primates (#719) Data reported in the poster build upon earlier preclinical findings reported by Xilio, which demonstrated that XTX301 was activated in a protease-dependent manner, including in human tumor samples ex vivo. Key findings from the poster are from preclinical studies in mouse and non-human primate (NHP) models, including comparisons between XTX301 and XTX30...