Business
Xilio Therapeutics Announces Pipeline and Business Updates and Second Quarter 2023 Financial Results
Xilio entered into clinical trial collaboration with Roche to evaluate XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4, in combination with atezolizumab
About this update from Xilio Therapeutics, Inc.
[{"type":"text","content":"Xilio entered into clinical trial collaboration with Roche to evaluate XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4, in combination with atezolizumab (Tecentriq®), in patients with microsatellite stable (MSS) colorectal cancer Xilio to host live virtual program spotlighting XTX101 on Thursday, August 17, 2023, at 12:30 p.m. ET Anticipate reporting preliminary Phase 1/2 data for XTX202, a tumor-activated IL-2, in early November 2023 Anticipate reporting preliminary Phase 1 safety data for XTX301, a tumor-activated IL-12, in the fourth quarter of 2023 Ended second quarter of 2023 with $75.4 million in cash and cash equivalents, with cash runway anticipated into the end of the second quarter of 2024 WALTHAM, Mass., Aug. 14, 2023 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology therapies for people living with cancer, today announced pipeline progress and business updates and reported financial results for the second quarter ended June 30, 2023. “In the second quarter, we reported encouraging initial monotherapy data from our Phase 1 trial of XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4, including a partial response in a patient with advanced non-small cell lung cancer and a favorable preliminary safety profile at the recommended Phase 2 dose,” said René Russo, Pharm.D., chief executive officer of Xilio. “Building on these data, today we are pleased to announce a clinical trial collaboration with Roche to evaluate XTX101 in combination with atezolizumab in patients with MSS colorectal cancer. Currently, there are no approved immunotherapies for patients living with this cold tumor type. We believe the combination of our tumor-activated anti-CTLA-4 with an anti-PD-L1 represents a promising combination for evaluation in MSS colorectal cancer and potentially other cold tumor types with limited treatment options. We also look forward to reporting preliminary clinical data later this year from our ongoing trials of XTX202, a tumor-activated IL-2, and XTX301, a tumor-activated IL-12.” Pipeline and Business Updates XTX101: tumor-activated, Fc-enhanced anti-CTLA-4 XTX101 is an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 designed to block CTLA-4 and deplete regulatory T cells when activa...