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Xenon Pharmaceuticals Showcases XEN1101 Epilepsy Program at 35th International Epilepsy Congress
New interim data from ongoing Phase 2b X-TOLE open-label extension demonstrates improvement in overall quality-of-life (QoL) when compared to baseline
About this update from Xenon Pharmaceuticals Inc.
[{"type":"text","content":"New interim data from ongoing Phase 2b X-TOLE open-label extension demonstrates improvement in overall quality-of-life (QoL) when compared to baseline Clinically important improvements seen for all patients across important subscales of Seizure Worry, Social Functioning and Medication Effects and for seizure free patients across all QoL subscales Oral presentations showcase Phase 3 clinical trials in focal onset seizures and primary generalized tonic-clonic seizures VANCOUVER, British Columbia, Sept. 04, 2023 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq:XENE), a neurology-focused biopharmaceutical company, today announced a summary of its oral and poster presentations at the 35th International Epilepsy Congress (IEC) taking place in Dublin, Ireland from September 2-6, 2023. Mr. Ian Mortimer, Xenon’s President and Chief Executive Officer, stated, “The IEC meeting in Dublin provides us with another key opportunity to connect with leading epileptologists and showcase our XEN1101 Phase 3 epilepsy program, which includes our ongoing X-TOLE2, X-TOLE3, and X-ACKT clinical trials in focal onset seizures and primary generalized tonic-clonic seizures, respectively. In addition, we presented interim data from the ongoing open-label extension study from our Phase 2b X-TOLE trial, showing the long-term efficacy of XEN1101 as demonstrated by patients experiencing continued seizure reduction during the OLE and extended periods of seizure freedom, which translates into overall improvements in patients’ quality of life. These new data related to quality-of-life improvements are consistent with the compelling clinical results generated to date and contribute to the growing evidence that support the promise of XEN1101 as a novel, differentiated potential treatment for patients with epilepsy.” An interim analysis (cutoff date September 22, 2022) of the ongoing X-TOLE open-label extension (OLE) study demonstrated that treatment with XEN1101 resulted in sustained monthly reduction in seizure frequency from double-blind period (DBP) baseline, with adverse events (AEs) consistent with previous results and those seen with other antiseizure medications (ASMs), and no new safety signals were identified. Newly compiled interim data from the X-TOLE OLE focused on quality-of-life (QoL) measures as assessed using a validated tool called the Quality ...