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Xencor Presents Updated Data from the Phase 1 Study of Vudalimab, PD-1 x CTLA-4 Bispecific Antibody, at the SITC Annual Meeting
-- Vudalimab was generally well-tolerated; objective responses observed across multiple tumor types -- -- Confirmed partial responses observed in two of four
About this update from Xencor, Inc.
[{"type":"text","content":"\n-- Vudalimab was generally well-tolerated; objective responses observed across multiple tumor types --\n\n-- Confirmed partial responses observed in two of four evaluable castration-resistant prostate cancer patients with measurable disease --\n\n-- Additional complete response observed in patient with advanced BRCA1+ high-grade serous ovarian cancer --\n\n MONROVIA, Calif.--(BUSINESS WIRE)--\nXencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, today reported data from its Phase 1 study evaluating vudalimab (XmAb®717), a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors (DUET-2). The updated results, predominantly from the study’s expansion cohorts, are presented in a poster titled, “Preliminary clinical experience with XmAb20717, a PD-1 x CTLA-4 bispecific antibody, in patients with advanced solid tumors” at the 36th Annual Meeting of the Society for Immunotherapy of Cancer (SITC).\n\n“Data from early-stage studies suggest that PD-1 and CTLA-4 inhibition has promise in prostate cancer, an area with high unmet need and without much checkpoint use. Dual targeting of these checkpoints through a bispecific antibody with a differentiated tolerability profile could meet an important unmet clinical need. In our Phase 1 study, we have observed vudalimab to be generally well tolerated, with lower rates of some types of immunotherapy-related adverse events, and to have encouraging clinical activity,” said Allen Yang, M.D., Ph.D., senior vice president and chief medical officer at Xencor. “We are now enrolling a Phase 2 study of vudalimab for patients with metastatic castration-resistant prostate cancer, as a monotherapy or in combination, depending on molecular subtype. In addition, we are initiating a second Phase 2 study in patients with advanced pelvic tumors, including clinically defined high risk mCRPC and certain gynecologic malignancies, which represent another opportunity for vudalimab’s dual targeting of PD-1 and CTLA-4 to address an unmet need.”\n\nAt the data cut off, 110 patients had been treated at the 10 mg/kg recommended dose level in dose-escalation (n=7) and in five dose expansion cohorts: melanoma (n=20), renal cell carcinoma (RCC, n=21), non-small cell lung cancer (...