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Xencor Presents Early Clinical Data from Combination Study of Vudalimab and New Data from Multiple Preclinical-stage XmAb® Programs at the SITC Annual Meeting
MONROVIA, Calif.--(BUSINESS WIRE)-- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for
About this update from Xencor, Inc.
[{"type":"text","content":" MONROVIA, Calif.--(BUSINESS WIRE)--\nXencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced the presentation of data from the first patients in the Phase 2 combination study of vudalimab, a selective PD-1 x CTLA-4 XmAb® bispecific antibody, in patients with metastatic castration-resistant prostate cancer (mCRPC) and data from multiple preclinical-stage XmAb programs at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) in Boston.\n\n“Evaluating chemotherapy combinations with vudalimab is an important part of our Phase 2 development plan due to the breadth of tumor types we could address with dual PD-1/CTLA-4 blockade and chemotherapy,” said Allen Yang, M.D., Ph.D., senior vice president and chief medical officer at Xencor. “Our initial combination data examines vudalimab with the aggressive chemotherapy regimen of a carboplatin and a taxane. Though we observed clinical activity, including multiple PSA50 responses and a partial response even in this small number of patients with advanced mCRPC, tolerability was a concern, so we are de-intensifying the chemotherapy regimen and maintaining the vudalimab dose. Consistent with our strategy of pursuing indications that checkpoint inhibitors have not yet addressed, we will continue to study a combination of platinum and taxane in patients with aggressive variant prostate cancer and a more broadly applicable chemotherapy combination with vudalimab and a taxane for other patients with mCRPC.”\n\nPosters will be available in the poster hall and virtually to registrants of the SITC Annual Meeting. In the poster hall, odd numbered posters will be displayed on Thursday, November 10, and even numbered posters will be displayed on Friday, November 11. The posters will be archived under \"Events & Presentations\" in the Investors section of the Company's website located at www.xencor.com.\n\nAbstract 668, “A Phase 2 study of vudalimab, a PD-1 x CTLA-4 bispecific antibody, plus chemotherapy or targeted therapy in patients with molecularly defined subtypes of metastatic castration-resistant prostate cancer”\n\nXencor is advancing vudalimab, a selective dual checkpoint inhibitor, in multiple Phase 2 clinical studies. The Company is conducting a...