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Xencor Highlights 2023 Corporate Priorities and Provides Portfolio Updates
MONROVIA, Calif.--(BUSINESS WIRE)-- Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for
About this update from Xencor, Inc.
[{"type":"text","content":" MONROVIA, Calif.--(BUSINESS WIRE)--\nXencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced 2023 corporate priorities and provided multiple clinical development updates.\n\nBassil Dahiyat, Ph.D., president and chief executive officer at Xencor, said:\n\n“The plug-and-play nature of Xencor’s XmAb® Fc domains and our protein engineering expertise have enabled a broad portfolio of bispecific antibody and engineered cytokine drug candidates in oncology and autoimmune disease, as well as a multitude of partnerships that continue to generate milestone payments and ongoing royalties. We seek to address challenging areas of biology with our drug candidates, testing them in early-phase clinical trials to rapidly determine which we advance internally, partner or terminate. In 2022 we advanced this strategy, presenting encouraging clinical data from multiple programs, stopping internal development of two programs, and expanding our clinical-stage portfolio with two novel format bispecific antibodies.\n\n“We are building on this momentum in 2023, progressing our clinical portfolio internally and with our co-development partners, including four bispecific antibody programs targeting solid tumors. Later this year, we will add a third engineered cytokine program to the clinic, following recent Phase 1 data for XmAb564, our regulatory T-cell targeting IL-2-Fc for autoimmune disease. We plan to present emerging clinical data as our programs advance and look forward to important updates and milestones from several partner programs throughout the year.”\n\nExecute on development plans for XmAb bispecific antibody and cytokine programs in oncology\n\nPlamotamab (CD20 x CD3), for B-cell malignancies\n\nXencor is co-developing plamotamab with Janssen Biotech, Inc. Xencor presented updated Phase 1 expansion cohort data for intravenously administered plamotamab in December 2022. In the fourth quarter of 2022, Xencor began dosing patients with subcutaneously administered plamotamab. Separately, the Company is winding down and ending enrollment in the Phase 2 study evaluating intravenous plamotamab in combination with tafasitamab and lenalidomide, in patients with relapsed or refractory diffuse large B-cell lymphoma, due to...