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VYNE Therapeutics Announces Formation of Scientific Advisory Board
Renowned Experts to Support VYNE’s Strategy of Developing Novel Treatments for Immunological and Inflammatory diseases SAB to Help Guide Clinical Development
About this update from Vyne Therapeutics Inc.
[{"type":"text","content":"Renowned Experts to Support VYNE’s Strategy of Developing Novel Treatments for Immunological and Inflammatory diseases SAB to Help Guide Clinical Development of VYNE’s BET Inhibitor Drug Candidates BRIDGEWATER, N.J., Oct. 21, 2021 (GLOBE NEWSWIRE) -- VYNE Therapeutics Inc. (Nasdaq: VYNE) (“VYNE” or the “Company”) today announced the formation of its Scientific Advisory Board (SAB) composed of leading scientists and clinicians specializing in immunological and inflammatory diseases. The SAB will provide scientific expertise and guidance to the VYNE management team and Board as the Company progresses its pipeline of innovative treatments for immuno-inflammatory conditions. These include the novel class of bromodomain and extra-terminal (BET) inhibitor compounds licensed through VYNE’s recent collaboration with In4Derm Limited, as well as FMX114 for the potential treatment of mild-to-moderate atopic dermatitis. “We recently announced our new strategic direction to focus on advancing our proprietary pipeline and develop treatments for immunological and inflammatory diseases,” said David Domzalski, CEO of VYNE. “The establishment of the SAB is an important step in our development plans, and we are delighted to welcome this team of esteemed and world-renowned medical experts who bring significant expertise, highly complementary skills and an external perspective.” BET proteins play a key role in regulating gene transcription via epigenetic interactions (“reading”), and recent research has determined a key role for these BET proteins in regulating B cell and T cell activation and subsequent inflammatory processes. As epigenetic readers, BET proteins regulate the recruitment of transcriptional factors that are key to the production of pro-inflammatory cytokines. Inhibiting BET proteins blocks cytokine transcription and therefore may have significant therapeutic potential across several immuno-inflammatory conditions. Iain Stuart, Chief Scientific Officer at VYNE, said “The SAB’s immediate focus is our recently licensed BET inhibitor platform. With the SAB’s appointment, VYNE will have access to the leading advisors from several therapeutic areas of interest for immunological and inflammatory conditions, which will optimize the development of our BET pipeline of highly differentiated treatments for these diseases.” VYNE’s SAB is comprise...