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vTv Therapeutics to Host Investor Call and Announce Results from Part 2 of the Phase 2 Simplici-T1 Study of TTP399 – Potential First-in-Class Oral Adjunctive Therapy for Patients with Type 1 Diabetes
Company will Release Results on Monday, February 10th at 7:00am Followed by an Investor Call Starting at 8:30am ET HIGH POINT, N.C., Feb. 07, 2020 (GLOBE
About this update from Vtv Therapeutics Inc.
[{"type":"text","content":"Company will Release Results on Monday, February 10th at 7:00am Followed by an Investor Call Starting at 8:30am ET\nHIGH POINT, N.C., Feb. 07, 2020 (GLOBE NEWSWIRE) -- vTv Therapeutics Inc. (Nasdaq: VTVT) today announced that it will release the topline results from Part 2 of the Phase 2 Simplici-T1 trial assessing TTP399 as an oral adjunctive therapy to insulin in adults with type 1 diabetes (T1D) on Monday, February 10th at 7:00am ET. vTv Therapeutics’ leadership team will then host an investor conference call that day at 8:30am ET.\n In June 2019, the company announced positive results from Part 1 of the Phase 2 study that showed a statistically significant reduction in HbA1c without increases in ketoacidosis or hypoglycemia. In Part 1, TTP399 was well tolerated with similar incidences of treatment-emergent adverse events overall and by system organ class. Part 1 had no serious adverse event reported, and no report of diabetic ketoacidosis or severe hypoglycemia. Investor Call and Webcast Dial-In Information Domestic: 877-423-9813 International: 201-689-8573 Conference ID: 13699047 Webcast: http://public.viavid.com/index.php?id=138082 About TTP399 The glucokinase enzyme (GK) is a key regulator of glucose metabolism, and its activation has been shown to increase glucose utilization, which in turn lowers blood glucose. TTP399 is an orally available GK activator that is designed for superior glucose control by targeting GK activation only in the liver with an insulin-independent mechanism of action. TTP399 has been studied in 12 clinical trials to date, including a 6-month Phase 2b trial in patients with type 2 diabetes where it demonstrated sustained, meaningful reductions in HbA1c and was well-tolerated, with negligible incidences of hypoglycemia and hyperlipidemia, and no occurrences of diabetic ketoacidosis. About Simplici-T1 Simplici-T1 is a multi-center, randomized, double-blind, adaptive study assessing the safety and efficacy of TTP399 as an adjunct to insulin therapy in adults with T1D. The primary endpoint was the change in HbA1c at week 12. The study was conducted with support from JDRF, the leading global organization funding research in type 1 diabetes. This Phase 2 learn-and-confirm study was conducted in two parts under the same protocol to evaluate the safety and efficacy of TTP399 in T1D patients over 12 weeks o...