Business
vTv Therapeutics Announces Reinitiation of Screening in CATT1 Phase 3 Trial Evaluating Potential First-in-Class Liver-Selective Glucokinase Activator Cadisegliatin for Type 1 Diabetes
Topline CATT1 Phase 3 data is expected in 2H 2026 Protocol amendment shortens trial duration from 12 to 6 months, expediting time to topline data HIGH POINT, N.C., May 15, 2025 (GLOBE NEWSWIRE) -- vTv Therapeutics Inc. (Nasdaq: VTVT), a late-stage biopharmaceutical company with an innovative clinical portfolio of small molecules and lead program in diabetes, today announced that screening has been reinitiated in the Company’s CATT1 Phase 3 trial investigating cadisegliatin as an adjunctive treat
About this update from Vtv Therapeutics Inc.
[{"type":"image","alt":"vTv Therapeutics Inc.","displaySize":"","headline":null,"caption":"vTv Therapeutics Inc.","className":"","disableSlideshowImg":false,"size":{"original":{"width":300,"height":156,"url":"https://media.zenfs.com/en/globenewswire.com/6b6b541287fc9ae12df42673a7e33331"},"resized":{"url":"https://s.yimg.com/ny/api/res/1.2/AM4EHLX89ULuROtlqZ7i2w--/YXBwaWQ9aGlnaGxhbmRlcjt3PTQyMDtoPTIxODtjZj13ZWJw/https://media.zenfs.com/en/globenewswire.com/6b6b541287fc9ae12df42673a7e33331","width":300,"height":156}},"lazy":false},{"type":"text","content":"Topline CATT1 Phase 3 data is expected in 2H 2026","length":49,"tagName":"p"},{"type":"text","content":"Protocol amendment shortens trial duration from 12 to 6 months, expediting time to topline data","length":95,"tagName":"p"},{"type":"text","content":"HIGH POINT, N.C., May 15, 2025 (GLOBE NEWSWIRE) -- vTv Therapeutics Inc. (Nasdaq: VTVT), a late-stage biopharmaceutical company with an innovative clinical portfolio of small molecules and lead program in diabetes, today announced that screening has been reinitiated in the Company’s CATT1 Phase 3 trial investigating cadisegliatin as an adjunctive treatment of type 1 diabetes (T1D). Cadisegliatin is a potential first-in-class, oral, liver-selective glucokinase activator for T1D that has been granted Breakthrough Therapy designation by the Food and Drug Administration (FDA).","length":579,"tagName":"p"},{"type":"text","content":"“We are thrilled that we have resumed our CATT1 Phase 3 trial and screened a subject under the amended protocol,” said Paul Sekhri, Chairman, President and Chief Executive Officer of vTv Therapeutics. “The amendment to the protocol will help expedite time to both topline data and the initiation of required larger pivotal studies moving us one step closer to the future New Drug Application (NDA) submission. We look forward to reporting topline Phase 3 data from CATT1 in the second half of 2026.”","length":499,"tagName":"p"},{"type":"text","content":"vTv Therapeutics reinitiated the CATT1 study and has screened a subject under a recently submitted protocol amendment that reduced the overall duration of the trial from 12 to 6 months, which will expedite time to topline data with no impact on the key study endpoints. Under the protocol amendment, continuous glucose monitors (CGM) will now be provided to all participants to inform the pri...