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Vor to Develop Multi-Targeted CAR-Ts with Abound Bio
CAMBRIDGE, Mass. and PITTSBURGH, June 10, 2021 (GLOBE NEWSWIRE) -- Vor Biopharma (Nasdaq: VOR) and Abound Bio today announced they have entered into a
About this update from Vor Biopharma Inc.
[{"type":"text","content":"CAMBRIDGE, Mass. and PITTSBURGH, June 10, 2021 (GLOBE NEWSWIRE) -- Vor Biopharma (Nasdaq: VOR) and Abound Bio today announced they have entered into a multi-year strategic collaboration and license agreement to research both single- and multi-targeted CAR-T treatments to be used in combination with Vor’s engineered hematopoietic stem cell (eHSC) platform, with the goal of generating novel treatment systems for patients fighting acute myeloid leukemia (AML) and other devastating forms of blood cancer. The partnership is a natural expansion of Vor’s mission to create eHSC therapies that unlock the potential of targeted treatments by protecting patients’ healthy cells. Through this alliance, the companies aim to develop therapies that target multiple antigens on patients’ cancer cells while removing or modifying the same targets on healthy cells through Vor’s novel eHSC platform, thereby shielding the patient’s hematopoietic system from unwanted side effects.Abound Bio was co-founded in 2019 by Dimiter “Mitko” Dimitrov, Ph.D., Chief Scientific Officer, a world-renowned antibody scientist who was previously a Senior Investigator at the National Cancer Institute, and John Mellors, M.D., Chief Executive Officer, an internationally recognized physician-scientist and academic leader. Rimas Orentas, Ph.D., who is a pioneer in CAR-T cell therapy, serves as Abound Bio’s Vice President for Cellular Therapy.“We are honored to work with Rimas, Mitko and John, leading experts in antibody discovery and engineering and CAR-T development,” said Sadik Kassim, Ph.D., Vor’s Chief Technology Officer. “The creation of best-in-class single- and multi-targeted CAR-T cells that can potentially be used in combination with our eHSC platform is an exciting area of exploration for Vor as we seek to transform the lives of cancer patients.” “While multi-targeted CAR-T cells are potentially more potent than treatments targeting single antigens, their use in AML has previously been limited by the greater threat they would pose to healthy blood cells,” said Dr. Rimas Orentas. “Our team is excited to partner with Vor, whose novel eHSC therapies could prove to be the key to enabling success for multi-specific CAR-Ts and achieving durable clinical responses for patients suffering from blood cancers.” Financial terms were not disclosed. About Vor BiopharmaVor Biophar...